Association of chest CT severity score with mortality of COVID-19 patients: a systematic review and meta-analysis

Zakariaee, Seyed Salman; Salmanipour, Hossein; Naderi, Negar; Kazemi-Arpanahi, Hadi; Shanbehzadeh, Mostafa

doi:10.1007/s40336-022-00512-w

Cited by 20 publications

(24 citation statements)

References 47 publications

(21 reference statements)

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“…Yuan et al (11) reported that patients with pulmonary involvement have a higher mortality rate. A metaanalysis including 7,106 COVID-19 patients also showed that thorax CT involvement in these patients could predict mortality (12). In accordance with the literature, our results showed a higher mortality rate with pulmonary involvement.…”

Section: Discussionsupporting

confidence: 91%

The mortality predictors in non-vaccinated COVID-19 patients

Güllü

Koca

2022

Journal of Health Sciences and Medicine

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Aim: The novel coronavirus (SARS-CoV-2) causes COVID-19 disease. From December 31, 2019, to the present (July 2022), 545 million new cases have been detected, while the number of deaths due to the disease has reached 6.3 million. This study aims to reveal mortality-related risk factors, including comorbid conditions, clinical course, imaging, and laboratory parameters in COVID-19 patients hospitalized in a tertiary hospital. Material and Method: An observational, retrospective study was conducted among hospitalized COVID-19 patients at the tertiary health center in Turkey between November 2020 and April 2021. A total of 601 patients were treated in this period and vaccinated 85 patients were excluded. The remaining 516 patients’ demographical data, clinical severity, laboratory parameters, thorax computed tomography (CT) involvement, and mortalities were recorded. Results: In evaluating the factors affecting COVID-19 mortality, it was observed that male gender and advanced age were significantly associated with mortality, and the mortality rate was higher in patients with involvement in thorax CT and patients with a clinically severe course. In the evaluation of the patients in terms of comorbidities, DM, HT, and CAD were significantly higher in the patients who died. It was determined that patients who died during hospitalization needed respiratory support at a higher rate. Conclusion: Identifying predicting factors is essential for the early recognition the vulnerable patients for hospitalization decisions and early aggressive treatment. In this study, male gender, advanced age, comorbidities (DM, HT, CAD), pulmonary involvement, and severe clinical presentation were identified as significantly related factors associated with mortality.

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Section: Discussionsupporting

confidence: 91%

The mortality predictors in non-vaccinated COVID-19 patients

Güllü

Koca

2022

Journal of Health Sciences and Medicine

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“…The outcome supports the hypothesis that CT-SS and COVID-19 mortality are directly correlated. There are greater mortality probabilities for COVID-19 patients with higher CT severity scores [20].…”

Section: Discussionmentioning

confidence: 97%

Clinical and Inflammatory Profile of COVID-19 Infection at a Tertiary Care Centre in Northern Part of Tamil Nadu – A Retrospective Study

Shanmukham¹,

Srivijayan²,

Venugopal³

et al. 2022

Cureus

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The coronavirus disease (COVID-19) pandemic has incurred high costs for the entire planet. The complex interactions between the host, virus, and environment have resulted in various clinical outcomes. It is crucial to comprehend sickness severity and outcome predictors to provide early preventative measures for a better outcome. The current study aimed to determine the association of clinical and inflammatory profiles with the outcome of COVID-19 infection in patients admitted to the intensive care unit. MethodsThis retrospective study was done in patients admitted to intensive care units for COVID-19 with a positive reverse transcriptase polymerase chain reaction (RTPCR) assay. A total of 125 patients above 18 years were included in the study. The patient's age, gender, and co-morbidities like type 2 diabetes mellitus, hypertension, respiratory illness, and coronary artery disease were noted. The patient's symptomatology, vital signs, oxygen saturation (Spo2), need for inotropes, and non-invasive positive pressure ventilator support (NIPPV) were observed. Computed tomography severity score (CTSS) and hematological and inflammatory parameters at the time of admission were noticed. Patient's management and treatment outcomes as survivors and non-survivors were noted. ResultsThe mean age was significantly greater in non-survivors. The common symptoms were fever, respiratory distress, cough, muscle pain, and sore throat. The leucocyte count, C-reactive protein (CRP), urea, creatinine, interleukin-6 (IL-6), and lactate dehydrogenase (LDH) were greater, and platelet counts were lower significantly in the non-survivors group. On multivariable logistic regression, CT severity score, NIPPV, and IL-6 had an odds ratio of 1.17, 0.052, and 1.03, respectively. IL-6 had a sensitivity of 81.5% and a specificity of 81.8% with a cut-off value of 37.5. ConclusionVigilant monitoring of leucocyte count, CRP, urea, creatinine, IL-6, LDH, platelet count, and CT severity score is essential for managing COVID-19 infection. IL-6 was found to be a significant marker as a predictor of outcome in our study.

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“…Interestingly, it was observed that the deceased patients had higher levels of leukocytes, neutrophils, and markers of inflammations, while the levels of lymphocytes and haemoglobin were significantly lower in relation to the patients who recovered [ 13 ]. Computed tomography revealed a higher degree of lung involvement in deceased patients [ 14 ]. Some studies indicate that the degree of lung involvement in unvaccinated patients is considerably higher than in those vaccinated with two doses of COVID-19 vaccines [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Course of COVID-19 among Unvaccinated Patients—Data from the National Hospital in Warsaw, Poland

et al. 2023

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Introduction. Studies to date indicate the relatively high effectiveness of vaccinations in preventing severe COVID-19 symptoms. However, in Poland, 40% of the population remains unvaccinated. Objective. The objective of this study was to describe the natural history of COVID-19 in unvaccinated hospital patients in Warsaw, Poland. Material and methods. This study evaluated data from 50 adult patients from the National Hospital in Warsaw, Poland, in the period 26 November 2021 to 11 March 2022. None of these patients had been vaccinated against COVID-19. Results. Analysis showed that the average hospitalisation time for these unvaccinated COVID-19 patients was 13 days. Clinical deterioration was observed in 70% of these patients, 40% required the intensive care unit, and 34% subsequently died prior to the end of the study. Conclusions. There was a significant deterioration and high mortality rate in the unvaccinated patients. For this reason, it seems prudent to take measures to increase the vaccination coverage level of the population against COVID-19.

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Association of chest CT severity score with mortality of COVID-19 patients: a systematic review and meta-analysis

Cited by 20 publications

References 47 publications

The mortality predictors in non-vaccinated COVID-19 patients

The mortality predictors in non-vaccinated COVID-19 patients

Clinical and Inflammatory Profile of COVID-19 Infection at a Tertiary Care Centre in Northern Part of Tamil Nadu – A Retrospective Study

The Course of COVID-19 among Unvaccinated Patients—Data from the National Hospital in Warsaw, Poland

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