Association of chemerin Rs17173608 and vaspin Rs2236242 gene polymorphisms with metabolic syndrome in Egyptian women

Abstract

Metabolic syndrome in Egyptian females is associated with the minor allele of chemerin rs17173608 polymorphism, whereas the minor allele of vaspin rs2236242 polymorphism plays a protective role against metabolic syndrome.

Pleiotropic Associations of RARRES2 Gene Variants and Circulating Chemerin Levels: Potential Roles of Chemerin Involved in the Metabolic and Inflammation-Related Diseases

“…Studies have reported the pleiotropic effects of RARRES2 SNPs, including a varying adiposity status, visceral fat mass, metabolic syndrome, and polycystic ovary syndrome [ 24 – 26 , 50 , 51 ]. The SNP rs17173608, the most commonly reported SNP associated with all the aforementioned phenotypes in non-Asian populations, was not associated with chemerin levels or various clinical characteristics, inflammatory biomarkers, or adipokines in our study population.…”

Chemerin Is an Indispensable Pre-Treatment Predictor of Sofosbuvir, Pegylated Interferon-Alpha and Ribavirin Outcomes in Chronic Hepatitis C Egyptian Patients

“…In the same line other study recorded that platelet counts and total bilirubin levels are associated with serum chemerin levels in patients with HCC (Imai et al, 2014). Interestingly, minor G allele of the chemerin rs17173608 polymorphism was significantly associated with metabolic syndrome in Egyptian patients (Mehanna et al, 2016). However, to the best of our knowledge chemerin association with treatment outcomes in CHC patients hasn't been studied yet.…”

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

“…Mehanna et al confirmed that in Egyptian females, the minor G allele of the chemerin rs17173608 polymorphism had a significantly higher frequency in metabolic syndrome patients than in the control subjects (OR = 0.351, 95% CI: 0.198-0.625, p = 0.0001), and the frequencies of TG and GG genotypes were significantly higher in metabolic syndrome patients (OR = 0.320, 95% CI: 0.166-0.619, p = 0.0001). The carriers of the G allele in the homozygous and heterozygous forms (GG and TG genotypes) also showed significantly higher BMI, waist circumference, systolic and diastolic blood pressures, fasting blood glucose, fasting serum insulin, insulin resistance, triglycerides, and total and LDL cholesterol, and lower HDL-cholesterol, compared with the carriers of the TT genotype [84].…”

“…In the Egyptian population of woman, Mahanna confirmed that the minor A allele of vaspin rs2236242 polymorphism plays a protective role against MetS (OR = 1.973 (1.227-3.171)). The carriers of vaspin rs2236242 TA and AA genotypes also significantly decreased BMI, waist circumference, sys-tolic and diastolic blood pressures, fasting blood glucose (FBG), fasting serum insulin, insulin resistance, TG, total cholesterol (TC), and LDL-C and increased HDL-C compared with the carriers of the TT genotype [84]. Opposing results were published by Alnory et al They showed no significant difference in the allele and genotype frequency of vaspin rs2236242 polymorphism between the MetS and non-MetS groups.…”