Association of Changes in Body Fatness and Fatty Acid Composition of Plasma Phospholipids During Early Puberty in Japanese Children

Abe, Yuriko; Okada, Tomoo; Iguchi, Hiromi; Saito, Emiko; Kuromori, Yuki; Iwata, Fujihiko; Hara, Mitsuhiko; Mugishima, Hideo; Kitamura, Yohei

doi:10.5551/jat.12476

Cited by 11 publications

(15 citation statements)

References 28 publications

(34 reference statements)

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“…Since high D9D activity seems to play a crucial role in obesity development a positive association of D9D with the T0 and T1 BMI was expected and confirmed in our study. As expected, our cross-sectional analysis showed a positive association of D6D and a negative association of D5D with the BMI z-score confirming results from Japanese studies in school children in which such associations were also found for weight status (21) and waist-to-height ratio (WtHR) (21,22). Also in 264 adolescents (mean age 15 years), D6D was positively associated with obesity (47).…”

Section: Desaturase Activity and Weight Statussupporting

confidence: 90%

“…the scale was converted to receive meaningful effect estimates in the models plasma lipids (1,2). To our knowledge only one other study investigated longitudinal relations of D9D with the weight status in children: Abe et al (21) compared the changes of the weight status with changes in D9D between baseline and a second measurement three years later and found no association. Since high D9D activity seems to play a crucial role in obesity development a positive association of D9D with the T0 and T1 BMI was expected and confirmed in our study.…”

Section: Desaturase Activity and Weight Statusmentioning

confidence: 99%

“…While D6D is positively associated with obesity and metabolic risk factors like dyslipidemia and insulin resistance, D5D is negatively related (21,22). The underlying mechanisms are still not well understood.…”

mentioning

confidence: 98%

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Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Wolters

Schlenz

Börnhorst

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Desaturase Activity and Weight Statussupporting

confidence: 90%

Section: Desaturase Activity and Weight Statusmentioning

confidence: 99%

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Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Wolters

Schlenz

Börnhorst

et al. 2015

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…We used ratios estimated from fatty acid composition as enzyme activity indices. These may be useful in epidemiological studies and indicate insulin resistance and metabolic disturbances [17,18]. However, verification based on accurate enzyme activity is necessary in pregnant women.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the analytical results of fatty acid composition, the estimated activity index of the following enzymes was calculated: fatty acid desaturases: stearoyl-CoA desaturase (SCD; 16-SCD; 16:1n-7/16:0, 18-SCD; 18:1n-9/18:0), delta-5 desaturase (D5D; 20:4n-6/20:3n-6), and delta-6 desaturase (D6D; 20:3n-6/18:2n-6), and a fatty acid chain-elongating enzyme: Elongase 6 (18:0/16:0) [17,18]. In addition, indices of fatty acid nutritional status: arachidonic acid (ARA)/linoleic acid, DHA/ARA, Omega 3 index (DHA + eicosapentaenoic acid [EPA]), essential fatty acid index (EFA index; Σn-3+n-6/Σn-7+n-9), DHA deficiency index (DHA/22:5n-6), and DHA sufficiency index (22:5n-6/22:4n-6), were calculated [19,20].…”

Section: Methodsmentioning

confidence: 99%

Relationship between Changes in Fatty Acid Composition of the Erythrocyte Membranes and Fatty Acid Intake during Pregnancy in Pregnant Japanese Women

Kitamura¹,

Kogomori

Hamano³

et al. 2017

Ann Nutr Metab

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Objective: Docosahexaenoic acid (DHA) is an important nutrient required by pregnant women and fetuses. Several studies suggest that fatty acid composition changes during pregnancy. However, the association of longitudinal changes in erythrocyte fatty acid composition and dietary fatty acid intake during pregnancy is not well understood. We assessed the relationship between fatty acid composition of the erythrocyte membranes and fatty acid intake at each trimester in pregnant Japanese women. Methods: We conducted a prospective hospital-based cohort study. We investigated fatty acid composition of the erythrocyte membranes and intake of fatty acids during the three trimesters in 178 healthy, pregnant Japanese women. Results: The eicosapentaenoic acid and arachidonic acid percentage of the erythrocyte membranes significantly decreased. The percentages of linoleic acid and α-linolenic acid significantly increased during pregnancy. The DHA percentage in the erythrocyte membranes decreased from the second to the third trimester. The DHA percentage in the erythrocyte membranes positively correlated with DHA intake in the third trimester. Conclusion: In pregnant Japanese women, the fatty acid composition of the erythrocyte membranes markedly changed throughout pregnancy. The DHA intake in the third trimester may be insufficient to maintain DHA percentage in the maternal erythrocyte membranes.

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Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys

Choi¹,

Jang²,

Park³

et al. 2014

Osong Public Health and Research Perspectives

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ObjectivesObesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders.MethodsAnthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards.ResultsActivities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up.ConclusionIn young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

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Association of Changes in Body Fatness and Fatty Acid Composition of Plasma Phospholipids During Early Puberty in Japanese Children

Cited by 11 publications

References 28 publications

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children

Relationship between Changes in Fatty Acid Composition of the Erythrocyte Membranes and Fatty Acid Intake during Pregnancy in Pregnant Japanese Women

Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys

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