Association of Cerebrovascular Events With Antidepressant Use: A Case-Crossover Study

Abstract

These findings suggest that antidepressant use may be associated with an increased risk of stroke. However, the underlying mechanisms remain unclear.

A Case‐crossover Study of Transient Risk Factors for Occupational Traumatic Hand Injuries in Incheon, Korea

“…In the medical field, the case-crossover design is used in studies related to injuries from traffic accidents 7,8) , injuries resulting from drinking 9) or factors triggering acute myocardial infarction 10) and cerebrovascular events 11) . Risk factors affecting occupational acute hand injuries are temporary in many cases and are such that the state of exposure changes over time.…”

Psychiatric Hospitalization Increases Short-Term Risk of Stroke

“…28 Moreover, the magnitude of this effect may be dependent on the duration of antidepressant treatment, with new users (but not long-term users) having an increased risk of stroke. 29 The increased risk of stroke after psychiatric hospitalization may therefore be at least partially attributable to the initiation of a new antidepressant medication.…”

The Controversy Over Antidepressant Drugs in an Era of Evidence-Based Practice

“…Csoka, Bahrick & Mehtonen (2008) report that sexual dysfunction can continue even after drugs are discontinued. Serotonin transporters, the target for the SSRIs, are also found on blood platelets and SSRIs are associated with risk of bleeding ulcers (Loke, Trivedi, and Singh, 2008;Serebruany, 2006) and stroke (Wu, Wang, Cheng, & Gau, 2011).…”