Association of Cerebral Deficits With Clinical Symptoms in Antipsychotic-Naive First-Episode Schizophrenia: An Optimized Voxel-Based Morphometry and Resting State Functional Connectivity Study

Lui, Su; Deng, Wei; Huang, Xiaoqi; Jiang, Lijun; Ma, Xiaoyan; Chen, Huafu; Zhang, Tijiang; Li, Xiuli; Li, Dongming; Zou, Ling; Tang, Hehan; Zhou, Xiaohong Joe; Mechelli, Andrea; Collier, David; Sweeney, John A.; Li, Tao; Gong, Qiyong

doi:10.1176/appi.ajp.2008.08020183

Cited by 230 publications

(160 citation statements)

References 53 publications

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“…Previous observations using self-reported measurement reported an inverse correlation between impulsive behaviour and GM volume in the lateral OFC (Lui et al 2009;Matsuo et al 2009). Boes et al (2009) showed that GM volume in the right MePFC predicted impulse control in adolescents.…”

Section: Introductionmentioning

confidence: 84%

Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex

et al. 2012

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Impulsivity is a complex behaviour composed of different domains encompassing behavioural disinhibition, risky decision-making and delay discounting abnormalities. To investigate regional brain correlates between levels of individual impulsivity and grey matter volume, we performed voxel-based morphometric correlation analysis in 34 young, healthy subjects using impulsivity scores measured with Barratt Impulsivity Scale-11 and computerized Kirby's delay discounting task. The VBM analysis showed that impulsivity appears to be reliant on a network of cortical (medial prefrontal cortex and dorsolateral prefrontal cortex) and subcortical (ventral striatum) structures emphasizing the importance of brain networks associated with reward related decisionmaking in daily life as morphological biomarkers for impulsivity in a normal healthy population. While our results in healthy volunteers may not directly extend to pathological conditions, they provide an insight into the mechanisms of impulsive behaviour in patients with abnormalities in prefrontal/frontal-striatal connections, such as in drug abuse, pathological gambling, ADHD and Parkinson's disease.

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Section: Introductionmentioning

confidence: 84%

Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex

et al. 2012

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“…In a followed study, the rsFC related to the DLPFC showed different asymmetry Table 1 and 2 pattern in predominantly positive and predominantly negative schizophrenia (Ke et al 2010). However, in a relative large sample of antipsychotic-naive first-episode schizophrenia patients, the altered rsFC related to the DLPFC was not found under a strict multiple comparison threshold (Lui et al 2009). In fact, in this study, no regions of identified gray matter deficits showed differences in the rsFC pattern between the patients and the normal controls.…”

Section: Spatial Pattern Analysismentioning

confidence: 91%

“…In fact, in this study, no regions of identified gray matter deficits showed differences in the rsFC pattern between the patients and the normal controls. But the functional networks involving the right superior temporal gyrus and middle temporal gyrus were found to be related with clinical symptom severity (Lui et al 2009). …”

Section: Spatial Pattern Analysismentioning

confidence: 99%

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

et al. 2010

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As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders.

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“…All participants were told that they were being recruited for an ongoing, large-scale imaging project investigating human brain function, and they did not know that the investigation was related to the earthquake at any point during the study. Healthy controls were recruited from Chengdu, within 50 miles from the epicenter, by poster advertisement and were scanned shortly before the earthquake for another study (47). All controls were also screened by using SCID-nonpatient version to confirm the lifetime absence of psychiatric illness.…”

Section: Methodsmentioning

confidence: 99%

High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China

Lui¹,

Huang

Chen³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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129

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Besides the enormous medical and economic consequences, national disasters, such as the Wenchuan 8.0 earthquake, also pose a risk to the mental health of survivors. In this context, a better understanding is needed of how functional brain systems adapt to severe emotional stress. Previous animal studies have demonstrated the importance of limbic, paralimbic, striatal, and prefrontal structures in stress and fear responses. Human studies, which have focused primarily on patients with clinically established posttraumatic stress disorders, have reported abnormalities in similar brain structures. At present, little is known about potential alterations of brain function in trauma survivors shortly after traumatic events. Here, we show alteration of brain function in a cohort of healthy survivors within 25 days after the Wenchuan earthquake by a recently discovered method known as ''restingstate'' functional MRI. The current investigation demonstrates that regional activity in frontolimbic and striatal areas increased significantly and connectivity among limbic and striatal networks was attenuated in our participants who had recently experienced severe emotional trauma. Trauma victims also had a reduced temporal synchronization within the ''default mode'' of restingstate brain function, which has been characterized in humans and other species. Taken together, our findings provide evidence that significant alterations in brain function, similar in many ways to those observed in posttraumatic stress disorders, can be seen shortly after major traumatic experiences, highlighting the need for early evaluation and intervention for trauma survivors.neuroimaging ͉ stress ͉ anxiety ͉ depression ͉ posttraumatic stress disorder I n the afternoon on May 12, 2008, the epicenter of a devastating earthquake occurred in Wenchuan, in the Sichuan Province of China. It measured 8.0 on the Richter scale. The most severely affected geographical regions were Yingxiu, Wenchuan, Dujiangyan, and Shifang, where 45 million people were directly affected. Among them, 69,146 people were confirmed dead, 374,131 were seriously injured, and 17,516 are missing. A significant proportion of the survivors (Ϸ20%) (1) are likely to develop stress-related disorders, such as acute stress disorder (ASD) and posttraumatic stress disorder (PTSD). Given the serious and persistent impact of these highly prevalent psychiatric disorders, it is vital to develop a better understanding of the alterations of cerebral function evident in the early stages of adaptation to trauma. Such knowledge may lead to a better understanding of posttraumatic responses and the development of more effective early interventions.Studies of animal models of acute and chronic stress have provided evidence of physiological and morphological changes in several brain regions, including the amygdala, hippocampus, and prefrontal cortex (2, 3). Human studies (4-12) have focused primarily on patients who already have an established psychiatric disorder, such as ASD and PTSD. Despite some inconsis...

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Association of Cerebral Deficits With Clinical Symptoms in Antipsychotic-Naive First-Episode Schizophrenia: An Optimized Voxel-Based Morphometry and Resting State Functional Connectivity Study

Cited by 230 publications

References 53 publications

Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex

Morphometric Correlation of Impulsivity in Medial Prefrontal Cortex

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

High-field MRI reveals an acute impact on brain function in survivors of the magnitude 8.0 earthquake in China

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