Association of central serotonin transporter availability and body mass index in healthy Europeans

Hesse, Swen; Giessen, Elsmarieke van de; Zientek, Franziska; Petroff, David; Winter, Karsten; Dickson, John; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, S.; Darcourt, Jacques; Akdemir, Ümit Özgür; Knudsen, Gitte M.; Nobili, Flavio; Pagani, Marco; Laere, Koen Van; Varrone, Andrea; Tatsch, Klaus; Sabri, Osama; Booij, Jan

doi:10.1016/j.euroneuro.2014.05.005

Cited by 34 publications

(33 citation statements)

References 35 publications

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“…Previous imaging studies showed a negative correlation between BMI and diencephalic SERT binding in some [6] but not all [29, 30, 31] studies, and data on insulin sensitivity were not reported.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans

Versteeg

Koopman²,

Booij

et al. 2016

Neuroendocrinology

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Background: Altered brain dopaminergic and serotonergic pathways have been shown in obese rodents and humans, but it is unknown whether this is related to obesity per se or to the metabolic derangements associated with obesity. Methods: We performed a case-control study in insulin-sensitive obese (ISO) and insulin-resistant obese (IRO) subjects (n = 12) and age-matched lean controls (n = 8) and measured serotonin transporter (SERT) binding in the whole diencephalon and specifically in the hypothalamus, as well as dopamine transporter (DAT) binding in the striatum using ¹²³I- FP-CIT single-photon emission computed tomography. We assessed insulin sensitivity using the homeostatic model assessment of insulin resistance. Results: BMI did not differ between the IRO and ISO subjects. SERT binding in the diencephalon was significantly lower in IRO than in ISO subjects, but was not different between lean and obese subjects. SERT binding in the hypothalamus tended to be reduced in obese versus lean subjects, but was not different between IRO and ISO subjects. Striatal DAT binding was similar between lean and obese subjects as well as between ISO and IRO subjects. Conclusions: We conclude that SERT binding in the diencephalon is reduced in insulin-resistant subjects independently of body weight, while hypothalamic SERT binding tends to be lower in obesity, with no difference between insulin-resistant and insulin-sensitive subjects. This suggests that the metabolic perturbations associated with obesity independently affect SERT binding within the diencephalon.

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Section: Discussionmentioning

confidence: 99%

Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans

Versteeg

Koopman²,

Booij

et al. 2016

Neuroendocrinology

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“…A positive correlation between BMI and SERT (serotonin transporter availability) has been documented (Hesse et al, 2014). A study using 11C-DASB PET, a marker of serotonin transporter availability, has shown correlations between serotonin transporter dysfunctions and abnormal changes in the BMI of PD patients (Politis, Loane, Wu, Brooks, & Piccini, 2011).…”

Section: Introductionmentioning

confidence: 97%

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

2015

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“…The moderating effects could also be explained by shared confounds between the studies. For instance, we were not able to consider previously reported moderators of the age effect such as body mass index (Hesse et al, 2014), sex hormones (Moses-Kolko et al, 2011), and genes (David et al, 2005).…”

Section: Discussionmentioning

confidence: 97%

“…Author, year r [95% CI] N 5-HT transporters RE Model Hesse, 2014Yamamoto, 2002Hesse, 2003Fazio, 2016van Dyck, 2000Kuikka, 2001Yamamoto, 2002Hesse, 2003 (Cumming, 2009).…”

Section: Correlation Coefficientmentioning

confidence: 99%

Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

Karrer

McLaughlin

Guaglianone

et al. 2018

Preprint

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Alterations in serotonin (5-HT) function have been hypothesized to underlie a range of physiological, emotional, and cognitive changes in older age. Here, we conducted a quantitative synthesis and comparison of the effects of age on 5-HT receptors and transporters from cross-sectional PET and SPECT imaging studies. Random-effects metaanalyses of 31 studies including 1087 healthy adults yielded large negative effects of age in 5-HT-2A receptors (largest in global cortex), moderate negative effects of age in 5-HT transporters (largest in thalamus), and small negative effects of age in 5-HT-1A receptors (largest in parietal cortex). Presynaptic 5-HT-1A autoreceptors in raphe/midbrain, however, were preserved across adulthood. Adult age differences were significantly larger in 5-HT-2A receptors compared to 5-HT-1A receptors. A meta-regression showed that 5-HT target, radionuclide, and publication year significantly moderated the age effects. The findings overall identify reduced serotonergic signal transmission in healthy aging. The evidence for the relative preservation of 5-HT-1A compared to 5-HT-2A receptors may partially explain psychological age differences, such as why older adults use more emotion-focused rather than problem-focused coping strategies.

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Association of central serotonin transporter availability and body mass index in healthy Europeans

Cited by 34 publications

References 35 publications

Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans

Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans

Body weight and food intake in Parkinson's disease. A review of the association to non-motor symptoms

Reduced serotonin receptors and transporters in normal aging adults: a meta-analysis of PET and SPECT imaging studies

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