Association of Celiac Disease with Aplastic Anemia

Maheshwari, Anu; Nirupam, Nilay; Aneja, Satinder; Meena, Raj Kumar; Chandra, Jagdish; Kumar, Praveen

doi:10.1007/s12098-011-0579-6

Cited by 12 publications

(13 citation statements)

References 5 publications

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“…A total of 11 cases with CD–AA association have been reported in the literature, out of which three are pediatric cases. In two of these three pediatric cases, both diseases were diagnosed simultaneously but in the third patient the diagnosis of AA is unconfirmed as no bone marrow biopsy was performed [ 8 , 9 ]. The most recent case developed AA after a previous diagnosis of CD [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…were symptom-free from a gastrointestinal standpoint while adhering to a gluten-free diet [ 3 ]. A gluten-free diet decreases the exposure to antigenic stimuli that lead to bone marrow suppression and reverts the process [ 8 ]. Our patient was put on a gluten-free diet but due to infrequent follow ups it is difficult to comment on her dietary adherence.…”

Section: Discussionmentioning

confidence: 99%

“…It is still debatable whether there should be a call for routine immunological testing for tissue transglutaminase antibodies in patients with AA. There is a need for studies focusing on this association since it has been a nonentity until recently [ 8 ]. All four pediatric cases regarding the CD–AA association have been reported from India or Pakistan as evident from Table 2 .…”

Section: Discussionmentioning

confidence: 99%

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Celiac disease associated with aplastic anemia in a 6-year-old girl: a case report and review of the literature

et al. 2018

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BackgroundCeliac disease may present with hematological abnormalities including long-standing anemia. Both aplastic anemia and celiac disease have a similar underlying autoimmune process but an association between the two is seldom reported. There have only been three pediatric cases reporting this association and this case is the first reported in a female pediatric patient.Case presentationWe report a case of 6-year-old South Asian girl presenting with bruises, petechiae, and recent history of loose stools. On evaluation, she was diagnosed as having celiac disease and was put on a gluten-free diet and further investigations including bone marrow biopsy revealed pancytopenia. She was managed with packed red cells, platelets, and diet restrictions and had improving platelet counts over yearly follow ups. Her parents were counseled regarding the need for bone marrow transplant.ConclusionsThis is the fourth case report suggesting an association between celiac disease and aplastic anemia in the pediatric population and this association could be more common than expected. Timely intervention of either celiac disease through strict gluten-free diet or aplastic anemia through immunosuppressive therapy could potentially reduce the risk for other autoimmune conditions. We can see that all four pediatric cases reported with this potential association are from South East Asia and hence larger studies would be prudent to explore this association.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Celiac disease associated with aplastic anemia in a 6-year-old girl: a case report and review of the literature

et al. 2018

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“…He did not need any immunosuppression. 4 Badyal et al reported a child with coeliac disease who was not under strict gluten free diet, developed aplastic anaemia. 5 Grey-Davies adult case series reported three patients who presented with aplastic anaemia associated with coeliac disease.…”

Section: Discussionmentioning

confidence: 99%

Childhood coeliac disease presenting as hepatitis with an associated aplastic anaemia: a case report and literature review

Krishnasamy

2016

Int J Contemp Pediatr

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Although aplastic anaemia and deranged liver function test are well documented in the adult coeliac literature, this combination is not well recognized in childhood. We report a case of 8 year old girl who presented with jaundice and spontaneous bruising. Initial investigations showed pancytopenia, raised bilirubin and transaminases. On extensive evaluation to look in to the cause of above presentation, she was found to have coeliac disease with aplastic anaemia. She was started on gluten free diet which resolved her liver derangement. The marrow aplasia persisted however, requiring immune therapies.

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“…Maheswari et al [8] reported a case of 13-yearold boy who presented with pain in bilateral knee and ankle joints accompanied by petechiae all over the body and hematochezia. On investigation for short stature, he was diagnosed as a case of celiac disease.…”

Section: Discussionmentioning

confidence: 99%

Rare Association of Coeliac Disease with Aplastic Anaemia: Report of a Case from India

Basu¹,

Ray²,

Bowmik³

et al. 2014

Indian J Hematol Blood Transfus

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Coeliac disease is a systemic autoimmune disorder with major intestinal manifestations. It has multiple hematologic associations including anaemia (mostly due to iron, folate and/or vitamin B12 malabsorption), other cytopenias, coagulation abnormalities, hyposplenism, IgA deficiency and lymphomas. Aplastic anaemia has however, only rarely been described with celiac disease in published literature. We here present a case of atypical coeliac disease in a 40 year male Indian patient, with insignificant gastrointestinal symptoms, presenting with aplastic anaemia manifested by pancytopenia with hypocellular bone marrow. On gluten free diet, his symptoms like weakness, fatigue and malaise were relieved-blood and platelet transfusion requirement also diminished.

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Association of Celiac Disease with Aplastic Anemia

Cited by 12 publications

References 5 publications

Celiac disease associated with aplastic anemia in a 6-year-old girl: a case report and review of the literature

Celiac disease associated with aplastic anemia in a 6-year-old girl: a case report and review of the literature

Childhood coeliac disease presenting as hepatitis with an associated aplastic anaemia: a case report and literature review

Rare Association of Coeliac Disease with Aplastic Anaemia: Report of a Case from India

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