Association of castration-dependent early induction of c-myc expression with a cell proliferation of the ventral prostate gland in rat

Abstract

The protooncogene c-myc is known to be associated with both cell proliferation and apoptosis. The possible cellular affects of castration on the ventral prostate gland of rat as well as the relationship to a castration induced c-myc expression were examined. Levels of c-myc mRNA in the ventral prostate gland peaked at 6 h (early induction) and 48 h (late induction) after castration, respectively. Castrationinduced DNA fragmentation was not observed at an early induction of c-myc mRNA. DNA fragmentation appeared to be testosterone-dependent. On the other hand, cellular DNA synthesis measured by [ 3 H]thymidine uptake in the ventral prostate gland was increased to maximum at 6 h after castration. These results suggest that an early induction of c-myc mRNA in ventral prostate gland after castration is closely associated with cell proliferation of the gland.

FLIP-ping out: Death receptor signaling in the prostate

“…First, c-myc mRNA levels increase following castration, as shown by multiple groups. [141][142][143] This might seem paradoxical, given the well-known role of c-myc in cell proliferation. However, it is now quite clear that c-myc can drive apoptosis under conditions where other proliferative signals (such as IGF-1) are absent or reduced.…”

Capturing Signal Anomalies of Human Prostate Cancer Into Mouse Models

“…91 It is also noteworthy that c-MYC levels are increased in the prostate after castration. 92 Furthermore, a recent study describes that overexpression of c-MYC may lead to defects in double-strand DNA break repair and induction of chromosome translocations, suggesting that c-MYC may serve as a "dominant mutator" to accelerate tumor development. 93 Microarray-based expression profiling of the c-myc transgenics has led to identification of some signature gene activities, which are shared between human and mouse prostate cancers.…”

Mechanism of Castration-induced Apoptosis of Ventral Prostate in Rat

“…이 선상피세포는 백서의 복 측전립선 세포의 약 85%를 차지하고 있으며 고환적출 후 7 일째에는 약 70%가 apoptosis된다고 한다 [16,17]. 고환절제 후 복측전립선에서 c-myc [18] (Fig. 3).…”