Association of carotid intima media thickness with atherogenic index of plasma, apo B/apo A-I ratio and paraoxonase activity in patients with non-alcoholic fatty liver disease

Fadaei, Reza; Meshkani, Reza; Fallah, Soudabeh; Panahi, Ghodratollah; Merat, Shahin; Golmohammadi, Taghi

doi:10.1080/13813455.2018.1429475

Cited by 24 publications

(32 citation statements)

References 29 publications

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“…We have also observed a negative correlation between FAM19A5 and cIMT. In line, previous studies have indicated association of other adipokines with cIMT in NAFLD patients (14,29). Moreover, several basic and pre-clinical studies demonstrated the vasculoprotective effects of adiponectin in atherosclerotic models.…”

Section: Discussionsupporting

confidence: 85%

“…Now NAFLD is considered as a potential independent risk factor for cardiovascular diseases (13). Several studies reported greater carotid artery intimal medial thickness in ultrasound-diagnosed NAFLD patients (14)(15)(16)(17). Moreover, it has been revealed that adipokines contribute to the cardiovascular homeostasis which affects vessel remodeling (18).…”

Section: Introductionmentioning

confidence: 99%

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Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

Yari

Shabani

Karami

et al. 2020

Preprint

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Background: Family with sequence similarity 19 (chemokine (C-C motif)-like) member A5 (FAM19A5) is a newly identified adipokine. There is a limited number of studies linking FAM19A5 to metabolic disorders. In the current study, we aimed to explore if FAM19A5 is associated with nonalcoholic fatty liver disease (NAFLD). We also sought to determine the possibility of FAM19A5 association with subclinical atherosclerosis in NAFLD patients. Methods: A total of 69 subjects including 37 NAFLD and 32 control subjects were included in this cross-sectional study. Plasma concentration of FAM19A5 was measured with the ELISA method. Carotid artery intima-media thickness (cIMT) was assessed by the ultrasonography.Results: Plasma concentration of FAM19A5 in patients with NAFLD was significantly lower in NAFLD patients than controls. Moreover, we observed significant negative correlations between plasma level of FAM19A5 and body mass index (BMI), visceral fat, alanine amino transferase (ALT), aspartate amino transferase (AST), liver stiffness (LS), and cIMT. Following stepwise multiple linear regression analysis, ALT and cIMT were the only determinants of FAM19A5 level. Conclusions: This is the first report to describe association of circulating FAM19A5 levels with NAFLD. Our findings provide further evidence showing relation of FAM19A5 with the risk of atherosclerosis. However, more studies are necessary to unravel the contribution of lower FAM19A5 levels to the NAFLD pathogenesis and the higher risk of atherosclerosis in these patients.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

Yari

Shabani

Karami

et al. 2020

Preprint

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“…Two studies were published in 2019 which evaluated PON1 activity in patients with NAFLD. A study conducted by Fadaei et al [40] showed decreased arylesterase and paraoxonase activities in patients with NAFLD (study conducted on 49 NAFLD patients), while the study performed by van den Berg et al [28] showed no variation in PON1 arylesterase activity according to an elevated fatty liver index (FLI). Their findings and our findings may become a shifting point in future PON1 status evaluations in patients with NALFD/NASH, from serum activities to serum concentrations.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

Milaciu

Vesa

Bocşan

et al. 2019

JCM

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Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was to evaluate PON1 serum concentration and PON1 gene polymorphisms in patients with NAFLD. Materials and methods: We studied a group of 81 patients with NAFLD with persistently elevated aminotransferases and a control group of 81 patients without liver diseases. We collected clinical information and performed routine blood tests. We also measured the serum concentration of PON1 and evaluated the PON1 gene polymorphisms L55M, Q192R, and C-108T. Results: There was a significant difference (p < 0.001) in serum PON1 concentrations among the two groups. The heterozygous and the mutated homozygous variants (LM + MM) of the L55M polymorphism were more frequent in the NAFLD group (p < 0.001). These genotypes were found in a multivariate binary logistic regression to be independently linked to NAFLD (Odds ratio = 3.4; p = 0.04). In a multivariate linear regression model, the presence of NAFLD was associated with low PON1 concentration (p < 0.001). Conclusions: PON1 serum concentrations were diminished in patients with NAFLD, and the presence of NAFLD was linked with low PON1 concentration. The LM + MM genotypes of the PON1 L55M polymorphism were an independent predictor for NAFLD with persistently elevated aminotransferases. Author Contributions: Conceptualization, M.V.M., L.C., I.C.B. and M.A.; methodology, M.V.M., L.C., M.A., and S , .C.V.; validation, M.A., L.C., D.M.M., V.N., D.S. and S.P.; formal analysis, S , .C.V.; investigation, M.V.M., L.C., R.M.P., I.C.B. and S.P.; resources, I.C.B., S , .C.V., R.M.P., D.M.M., A.D.B. and A.L.R.; writing-original draft preparation, M.V.M.; writing-review and editing, S , .C.V., L.C., I.C.B. and M.A.; visualization, A.L.R.; supervision,

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“…19,20 It has been well reported that apolipoproteins play an important part in the process. [21][22][23] Among the family of apolipoproteins, ApoA1 is the major constituent in HDL particles. 24 ApoB mainly includes ApoB-48, which complexes with free cholesterol and dietary TG, and ApoB-100, which presented in LDL, intermediate LDL (IDL), very LDL (VLDL) and small dense LDL (sd-LDL).…”

Section: Discussionmentioning

confidence: 99%

“…Most dyslipidemia can result in a high risk of atherosclerotic disease in the general population 19,20 . It has been well reported that apolipoproteins play an important part in the process 21‐23 . Among the family of apolipoproteins, ApoA1 is the major constituent in HDL particles 24 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of carotid plaque presence in peritoneal dialysis patients and its association with the apolipoprotein B/apolipoprotein A1 ratio

et al. 2020

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Aim: Atherosclerosis has been reported as a risk factor for cardiovascular disease in the general population. As a phenotype of atherosclerosis, carotid plaque and its influence factors are rarely discussed among dialysis patients. The study aimed to investigate the prognosis-predictive significance of carotid plaques in patients on peritoneal dialysis (PD), and explore risks factors for carotid plaque presence. Methods: It was an observational, prospective study. Patients that had undergone stable PD for at least 3 months were recruited and divided into two subgroups: group with carotid plaques and group without carotid plaques. Cox regression model was used to identify independent predictors of all-cause mortality, cardiovascular events (CVEs), and cardiovascular mortality. Pathogenic factors correlated to the plaqueoccurrence were explored by logistic regression and verified by receiver operating characteristic (ROC) curve analysis. Results: A total of 233 PD patients were recruited. The cohort was followed for up to 86 months. The carotid plaque presence turned out to be an independent risk fac

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Association of carotid intima media thickness with atherogenic index of plasma, apo B/apo A-I ratio and paraoxonase activity in patients with non-alcoholic fatty liver disease

Abstract: The result showed that AIP and apo B/apo A-I associated with cIMT in NAFLD patients; however, more study are needed to prove this concept.

Cited by 24 publications

References 29 publications

Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease

Paraoxonase-1 Serum Concentration and PON1 Gene Polymorphisms: Relationship with Non-Alcoholic Fatty Liver Disease

Prognostic significance of carotid plaque presence in peritoneal dialysis patients and its association with the apolipoprotein B/apolipoprotein A1 ratio

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