Association of Cardiopulmonary Exercise Capacity and Adipokines in
                    the General Population

Lendeckel, Frederik; Zylla, Stephanie; Markus, Marcello Ricardo Paulista; Ewert, Ralf; Gläser, Sven; Völzke, Henry; Albrecht, Diana; Friedrich, Nele; Nauck, Matthias; Felix, Stephan B.; Dörr, Marcus; Bahls, Martin

doi:10.1055/a-1699-2380

Cited by 5 publications

(3 citation statements)

References 57 publications

(75 reference statements)

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“…While the positive effects of exercise training interventions on adipokine profiles have been well documented, 19 few studies have examined the association of adipokines with exercise capacity. 20 Although our study helps to fill this knowledge gap and adds to our understanding of the relationship between obesity, adipokines, and exercise intolerance in HFpEF, we did not find an association between obesity-associated biomarkers and PCWP/ CO. a defining feature of diastolic reserve. Nevertheless, higher levels of CRP and leptin did associate with a greater exercise PCWP and higher odds of HFpEF.…”

Section: Discussioncontrasting

confidence: 56%

Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Ramirez,

Lau,

Parekh

et al. 2023

Circ: Heart Failure

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Background: Obesity and adiposity are associated with an increased risk of heart failure with preserved ejection fraction (HFpEF); yet, specific underlying mechanisms remain unclear. We sought to examine the association of obesity-related biomarkers including adipokines (leptin, resistin, adiponectin), inflammatory markers (CRP [C-reactive protein], IL-6 [interleukin-6]), and insulin resistance (HOMA-IR) with HFpEF status, exercise capacity, and cardiovascular outcomes. Methods: We studied 509 consecutive patients with left ventricular ejection fraction ≥50% and chronic dyspnea, who underwent clinically indicated cardiopulmonary exercise test with invasive hemodynamic monitoring between 2006 and 2017. We defined HFpEF based on the presence of elevated left ventricular filling pressures at rest or during exercise. Fasting blood samples collected at the time of the cardiopulmonary exercise test were used to assay obesity-related biomarkers. We examined the association of log-transformed biomarkers with HFpEF status and exercise traits using multivariable-adjusted logistic regression models. Results: We observed associations of obesity-related biomarkers with measures of impaired exercise capacity including peak VO 2 ( P ≤0.002 for all biomarkers). The largest effect size was seen with leptin, where a 1-SD higher leptin was associated with a 2.35 mL/kg per min lower peak VO 2 (β, −2.35±0.19; P <0.001). In addition, specific biomarkers were associated with distinct measures of exercise reserve including blood pressure (homeostatic model assessment of insulin resistance, leptin, adiponectin; P ≤0.002 for all), and chronotropic response (CRP, IL-6, homeostatic model assessment of insulin resistance, leptin, and resistin; P <0.05 for all). Our findings suggest that among the obesity-related biomarkers studied, higher levels of leptin and CRP are independently associated with increased odds of HFpEF, with odds ratios of 1.36 (95% CI, 1.09–1.70) and 1.25 (95% CI, 1.03–1.52), respectively. Conclusions: Specific obesity-related pathways including inflammation, adipokine signaling, and insulin resistance may underlie the association of obesity with HFpEF and exercise intolerance.

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Section: Discussioncontrasting

confidence: 56%

Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Ramirez,

Lau,

Parekh

et al. 2023

Circ: Heart Failure

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“…Quantile regression is used by researchers for modeling and predicting VO 2 max [ 39 , 40 ] because it does not assume underlying normality but is more robust in regard to normal errors and outliers.…”

Section: Methodsmentioning

confidence: 99%

Predicting VO2max in Children and Adolescents Aged between 6 and 17 Using Physiological Characteristics and Participation in Sport Activities: A Cross-Sectional Study Comparing Different Regression Models Stratified by Gender

et al. 2022

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Background: The aim of this study is to use different regression models to capture the association between cardiorespiratory fitness VO2max (measured in mL/kg/min) and somatometric characteristics and sports activities and making better predictions. Methods: multiple linear regression (MLR), quantile regression (QR), ridge regression (RR), support vector regression (SVR) with three different kernels, artificial neural networks (ANNs), and boosted regression trees (RTs) were compared to explain and predict VO2max and to choose the best performance model. The sample consisted of 4908 children (2314 males and 2594 females) aged between 6 and 17. Cardiorespiratory fitness was assessed by the 20 m maximal multistage shuttle run test and maximal oxygen uptake (VO2max) was calculated. Welch t-tests, Mann–Whitney-U tests, X2 tests, and ANOVA tests were performed. The performance measures were root mean square error (RMSE), mean absolute error (MAE), and coefficient of determination (R2). All analyses were stratified by gender. Results: A comparison of the statistical indices for both the predicted and actual data indicated that in boys, the MLR model outperformed all other models in all indices, followed by the linear SVR model. In girls, the MLR model performed better than the other models in R2 but was outperformed by SVR-RBF in terms of RMSE and MAE. The overweight and obesity categories in both sexes (p < 0.001) and maternal prepregnancy obesity in girls had a significant negative effect on VO2max. Age, weekly football training, track and field, basketball, and swimming had different positive effects based on gender. Conclusion: The MLR model showed remarkable performance against all other models and was competitive with the SVR models. In addition, this study’s data showed that changes in cardiorespiratory fitness were dependent, to a different extent based on gender, on BMI category, weight, height, age, and participation in some organized sports activities. Predictors that are not considered modifiable, such as gender, can be used to guide targeted interventions and policies.

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“…This appeared to be confirmed by a single study, and when adiponectin was removed, this association disappeared. Recently, Lendeckel et al (2022) demonstrated the same direction of adiponectin and aerobic capacity regarding lifestyle modifications in obese patients with chronic kidney disease [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals

et al. 2022

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We investigated the effects of Irvingia gabonensis (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight/obese individuals. All participants used the first 12-week phase to monitor body weight. They were then randomly divided into two groups: (1) 300 mg IG or (2) placebo (PLA). Both groups took one tablet per day for 12 weeks. The variables were measured before supplementation and after 3, 6, and 12 weeks of supplementation. RTL and aerobic capacity were measured before and after 12 weeks. Compared with the PLA, the IG increased plasma vitamin C after supplementation at 6 (p < 0.01) and 12 weeks (p < 0.05) and serum adiponectin after 3 weeks (p < 0.05). Compared with before supplementation, plasma malondialdehyde and serum leptin were decreased after 12-week supplementation in both groups and in the PLA, respectively, without any differences between the groups. There were no differences between groups with respect to metabolism, inflammation, RTL, and aerobic capacity after the supplementation. We suggest that 12-week daily IG supplementation improved plasma vitamin C and adiponectin. The findings show the possible mechanism contributing to the effect of IG supplementation on a reduction in obesity-related complications.

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Association of Cardiopulmonary Exercise Capacity and Adipokines in the General Population

Cited by 5 publications

References 57 publications

Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Obesity-Related Biomarkers Are Associated With Exercise Intolerance and HFpEF

Predicting VO2max in Children and Adolescents Aged between 6 and 17 Using Physiological Characteristics and Participation in Sport Activities: A Cross-Sectional Study Comparing Different Regression Models Stratified by Gender

Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals

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