Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population

Abstract

A number of genetic loci have been proposed to be associated with persistent hepatitis B virus (HBV) infection. This study aimed to evaluate the association and interaction of susceptible genes with HBV persistence in a Chinese population. A total of 17 polymorphisms in 9 candidate genes were studied in 361 Chinese chronic hepatitis B patients and 304 patients who recovered spontaneously. Distributions of susceptible polymorphisms were examined in healthy Chinese and Caucasian populations. Gene-gene interactions were tested by the multifactor dimensionality reduction (MDR) method. The TNF -308 G/G genotype and G allele, IL-10RB codon 47 A allele, and MCP-1 -2518 G/G genotype and G allele were more frequent in patients than controls (P < 0.01, after multiple corrections Pc < 0.05), while the frequencies of TNF -308 A/G genotype and IL-10 -592 A/A genotype were significantly higher in controls than in the patient group (Pc < 0.05). The frequencies of the risk allele MCP-1 -2518 G and CTLA4 6230 G were much higher in Chinese than in the Caucasian groups (P < 0.001). An interaction between CCR5 -2459, TNFA -863, IL-10RB codon 47, and MCP-1 -2518 was detected by MDR (P = 0.001). The results indicate that genetic determinants may affect the outcome of HBV infection in both independent and synergic manners. J. Med. Virol. 82:371-378, 2010. (c) 2010 Wiley-Liss, Inc.

Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients

“…These contradictory results could be partly explained by the extreme complexity in the cytokine network related to the intricate interactions of cytokines by which they induce or suppress their own synthesis or that of other cytokines, and antagonize or synergize with each other in many different and often redundant ways. On the other hand, it is now obvious that interactions between host genetic polymorphisms should be taken into account in defining complex and multifactorial disease risk, such as hepatitis C. Although the risk attributed to an individual polymorphism is often very small, it has been repeatedly demonstrated that a combination of specific genotypes may be a more significant and powerful approach in predicting disease risk [38][39][40][41].…”

Association of Monocyte Chemoattractant Protein‐1 (MCP‐1)‐2518A>G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta‐Analysis

“…It has been suggested that the frequency of the risk allele MCP-1 -2518G was much higher in Asians than in the Caucasian population (Chen et al, 2010). This discrepancy might be the result of distinct ethnicity-related factors.…”

Infectious disease — a genetic view

“…Some genes and loci, such as those encoding the Major Histocompatibility Antigens (HLA) [5,6], mannosebinding lectin/protein (MBP/MBL) [7,8], tumor necrosis factor (TNF) [9,10], natural resistance associated macrophage protein 1/ solute carrier family 11, member 1 (NRAMP1/SLC11A1) [11], vitamin D receptor (VDR) [12] and haptoglobin [13], control susceptibility to a variety of pathogens. Others, such as erythrocyte protein 3 (SLC4A1) [14], have been described as controlling susceptibility to only a single disease [15].…”

“…Coding changes in two of the genes in this locus, type I IFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-lambdas, are associated with viral clearance [28]. Weak effects were reported for the HLA [6] and TNFA [10] genes, and the effect of mutation in MBP (mannose-binding protein) / MBL (mannosebinding lectin) gene was observed only in certain populations [8].…”