Association of Candida with Linear Gingival Erythema in HIV-Infected Subjects

Seneviratne, Chaminda Jayampath; Jayasinghe, Ruwan Duminda

doi:10.1007/978-3-662-47194-4_12

Cited by 1 publication

(2 citation statements)

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“…), as well as the influence of cultural and geographical factors of Furthermore, EC-Clearinghouse classification has also associated LGE to be more prevalent in children HIV infection than in adults. 18 Comparing this study to another study conducted in 2014 among adult patients at the same centre (UPIPI, Soetomo General Hospital) supports this classification as LGE was found to be much lower in adult patients (5.83%) than among pediatric children in this study. 23 ART has been widely accepted to be highly effective at inhibiting HIV replication, although it is not curative.…”

Section: Discussionsupporting

confidence: 80%

“…Despite the discrepancies between studies, it is now widely accepted that Candida contributes to the occurrence of LGE as many clinical cases were effectively treated with antifungal treatment. 15,18 In this study, the prevalence of LGE was found to be 21.43%. This prevalence is higher than other studies in developing countries in Uganda (0.84%) 19 and India (2.27% 20 and 9.05% 21 ) yet lower than a study conducted in Venezuela (27.03%) 22 .…”

Section: Discussionmentioning

confidence: 51%

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Sensitivity and Specificity of Linear Gingival Erythema as Immune Suppression Marker in Pediatric HIV-infected at UPIPI Soetomo General Hospital Surabaya, Indonesia

Mensana¹,

Nugraha²,

Ernawati³

et al. 2019

Ind. Jour. of Publ. Health Rese. & Develop.

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Introduction: Strikingly, more than 95% pediatric HIV infections worldwide are in developing countries.Although ART can reduce significantly the risk of HIV transmission to children born from HIV-infected mothers, this can be effective only if the women know their HIV status. In many developing countries, such as Indonesia, the lack of access by pregnant mothers to laboratory facilities may deprive them of knowing their HIV status, thus the opportunity to transmit the disease to their children is high, knowing no preventive intervention is attempted. To date, it is estimated that the number of HIV infected children in Indonesia who are left undiagnosed is still high, therefore a study on clinical markers of HIV that can aid in the diagnosis and predict the severity of the disease among children is critical. In this study, Linear Gingival Erythema is assessed on its correlation to degree of immune suppression to be used as HIV clinical marker in laboratorypoor settings in Indonesia. Method: HIV-infected children admitted to Soetomo General Hospital between June -October 2017 were screened and examined intraorally for the presence of LGE. Other relevant data were obtained from questionnaire-guided interview to parents/guardians and from patient's medical record. Results:LGE was found in 21.43% children and statistical analysis shows significant correlation of LGE to degree of immune suppression. Conclusion: Further study with larger study population size is required to analyze the sensitivity and specificity of LGE to be used as HIV marker in predicting a particular degree of immune suppression, specific to Indonesian pediatric population.

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Section: Discussionsupporting

confidence: 80%