Association of Calpastatin Polymorphism with Carcass and Meat Quality Traits of Bandur Sheep

Kumar, Sachin; Jayashankar, M. R.; Ruban, S. Yu.; Sreesujatha, R. M.; Devi, YS

doi:10.5455/ijlr.20171012064140

Cited by 2 publications

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“…Kumar et al. (2018) studied carcass and meat quality traits in lambs belonging to two CAST alleles M and N and observed that sheep with N allele had lower shear force indicating greater meat tenderness and higher ash percentage. The results of all these reported studies have consistently indicated that polymorphisms in the CAST gene could play a crucial role in determining traits such as FE, carcass quality, and meat quality.…”

Section: Resultsmentioning

confidence: 99%

“…Dorset sheep carrying the 'ac' genotype of the CAST gene exhibited markedly higher daily live weight gain and produced carcasses weighing 12%-17% more compared to those carrying the 'aa' and 'ab' genotypes (Palmer et al, 1999). Kumar et al (2018) two CAST alleles M and N and observed that sheep with N allele had lower shear force indicating greater meat tenderness and higher ash percentage. The results of all these reported studies have consistently indicated that polymorphisms in the CAST gene could play a crucial role in determining traits such as FE, carcass quality, and meat quality.…”

Section: Callipyge Calpastatin and Myostatinmentioning

confidence: 92%

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Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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Feed costs and carcass yields affect the profitability and sustainability of sheep production. Therefore, it is crucial to select animals with a higher feed efficiency and high‐quality meat production. This study focuses on the impact of dietary and genetic factors on production traits such as feed efficiency, carcass quality, and meat quality. Diets promote optimal sheep growth and development and provide sufficient protein can lead to higher‐quality meat. However, establishing an optimized production system requires careful consideration and balance of dietary parameters. This includes ensuring adequate protein intake and feeding diets with higher intestinal absorption rates to enhance nutrient absorption in the gut. The study identifies specific genes, such as Callipyge, Calpastatin, and Myostatin, and the presence of causal mutations in these genes, as factors influencing animal growth rates, feed efficiency, and meat fatty acid profiles. Additionally, variants of other reported genes, including PIGY, UCP1, MEF2B, TNNC2, FABP4, SCD, FASN, ADCY8, ME1, CA1, GLIS1, IL1RAPL1, SOX5, SOX6, and IGF1, show potential as markers for sheep selection. A meta‐analysis of reported heritability estimates reveals that residual feed intake (0.27 ± 0.07), hot carcass weight (0.26 ± 0.05), dressing percentage (0.23 ± 0.05), and intramuscular fat content (0.45 ± 0.04) are moderately to highly heritable traits. This suggests that these traits are less influenced by environmental factors and could be improved through genetic selection. Additionally, positive genetic correlations exist between body weight and hot carcass weight (0.91 ± 0.06), dressing percentage (0.35 ± 0.15), and shear force (0.27 ± 0.24), indicating that selecting for higher body weight could lead to favorable changes in carcass quality, and meat quality.

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Section: Resultsmentioning

confidence: 99%

Section: Callipyge Calpastatin and Myostatinmentioning

confidence: 92%

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Chacko Kaitholil,

Mooney,

Aubry

et al. 2023

Animal Genetics

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Single Loci and Haplotypes in CAPN1 and CAST Genes are Associated with Growth, Biometrics, and in Vivo Carcass Traits in Santa Inês Sheep

Machado

Meira

Muniz

et al. 2020

Annals of Animal Science

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Abstractµ-calpain (CAPN1) and calpastatin (CAST) genes play key roles in protein turnover. The present study aimed to identify the variants in these genes associated with growth and ultrasound carcass traits in Santa Inês sheep. A sample of 192 no full sibling Santa Inês lambs was used. Fragments of the CAST and CAPN1 genes were amplified and next-generation sequencing was performed in the MiSeq platform. Variants in the CAPN1 and CAST sequences were then detected using bioinformatic tools. Withers and croup heights, body length, thoracic and croup widths, thoracic and leg girths, body depth, carcass fat score, rib eye area, fat thickness, body weights were recorded at weaning and at 140 days post-weaning, and average daily gain post-weaning was calculated. Both single-locus and haplotype association analyses were performed with the model as follows: farm (2 levels), year (4 levels), the month of birth (12 levels), and the covariate age of the animal. The fragments amplified included 4,514 bp between the 20th and 23rd exons of CAST as well as 3,927 bp between the 12th and 21st exons of CAPN1. In these regions, 58 (CAST) and 45 (CAPN1) variants were identified. In the CAST gene, the single-locus analysis revealed 22 suggestive additive effects (P<0.05) on several growth and carcass traits. Moreover, haplotype substitutions were associated with rib eye area (–0.689±0.290), average daily gain (–23.6±10.4), thoracic girth (–2.72±1.27), body length (–3.38±1.49), and leg girth (–2.84±1.37). Regarding the CAPN1 gene, the single-locus analysis identified seven suggestive additive effects, while only one haplotype replacement effect on fat thickness (–0.0143±0.0053) was detected. The results of the present study suggest that variants in the CAPN1 and CAST genes are associated with growth and ultrasound carcass traits in Santa Inês sheep, which may be a source of information to improve knowledge regarding the genetic control of these traits.

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Association of Calpastatin Polymorphism with Carcass and Meat Quality Traits of Bandur Sheep

Cited by 2 publications

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Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Insights into the influence of diet and genetics on feed efficiency and meat production in sheep

Single Loci and Haplotypes in CAPN1 and CAST Genes are Associated with Growth, Biometrics, and in Vivo Carcass Traits in Santa Inês Sheep

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