Association of calorie and carbohydrate intake with tumour grade in early diagnosis of breast cancer: a case–control study

Hatami, Mahshid; Doaei, Saeid; Jarrahi, Seyed Alireza Mosavi; Mirsafa, Faezeh; Davoodi, Sayed Hossein

doi:10.1080/13813455.2020.1754430

Cited by 2 publications

(1 citation statement)

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“…Breast cancer (BC) is the most common cancer in women and a major public health concern around the world. In 2020, there was approximately 2.26 million newly diagnosed female BC worldwide (Chen et al, 2020;Ferlay et al, 2021;Hatami et al, 2022), and the cases are expected to reach 4.4 million in 2070 . Additionally, BC accounted for nearly 15.5% of Approximately 75% of breast cancer patients worldwide are treated with RT as adjuvant therapy after surgery.…”

Section: Introductionmentioning

confidence: 99%

Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dahka

Afsharfar

Tajaddod

et al. 2023

Asian Pac J Cancer Prev

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Background: Radiation dermatitis (RD) is a common side effect of radiotherapy in most breast cancer patients. Curcumin has recently attracted more attention for managing the side effects of breast cancer treatments. This review study aimed to investigate the effect of curcumin on the severity of radiation dermatitis in patients with breast cancer. Methods: All eligible randomized controlled trials (RCTs) were collected by searching PubMed, Scopus, Cochrane, and Web of Science. The effect size was expressed as weighted mean difference (WMD) and 95% confidence interval (CI). Study heterogeneity was assessed through Q statistics and I-squared. Results: Four RCTs with 882 patients were included in the final analysis. The results of the meta-analysis indicated that curcumin supplementation significantly reduced radiation dermatitis severity (RDS) score in the intervention group compared to the control group (WMD=-0.50; 95% CI -0.72 to -0.27, P <0.001). A significant heterogeneity was observed between the studies (I 2 = 95.7%, P < 0.001). Conclusion:Based on the results of the present study, curcumin has significant effects in reducing the severity of radiation dermatitis in breast cancer patients receiving radiotherapy. Further well-designed longitudinal studies are recommended to confirm these results and to discover the underlying mechanisms of the effects of curcumin on the severity of radiation dermatitis in patients with cancer.

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Section: Introductionmentioning

confidence: 99%

Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dahka

Afsharfar

Tajaddod

et al. 2023

Asian Pac J Cancer Prev

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Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer

Abdollahi

Ardekanizadeh

Poorhosseini

et al. 2022

Advances in Nutrition

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Carcinogenesis as a complicated process originates from genetic, epigenetic, and environmental factors. Recent studies have reported a potential critical role for the fat mass and obesity-associated (FTO) gene in carcinogenesis through different signaling pathways such as mRNA N6-methyladenosine (m6-A) demethylation. The most common internal modification in mammalian mRNAs is the m6-A RNA methylation that has a significant biological functioning through regulation of cancer-related cellular processes. Some environmental factors, like physical activity and dietary intake, may influence signaling pathways engaged in carcinogenesis, through regulating FTO gene expression. Also, people with FTO gene polymorphisms may be differently influenced by cancer risk factors. For example, FTO risk allele carriers may need higher intake of nutrients to prevent cancer than others. In order to obtain a deeper viewpoint of the FTO, lifestyle, and cancer-related pathway interactions, this review aims to discuss upstream and downstream pathways associated with the FTO gene and cancer.

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Association of calorie and carbohydrate intake with tumour grade in early diagnosis of breast cancer: a case–control study

Cited by 2 publications

References 20 publications

Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Impact of Curcumin Supplementation on Radiation Dermatitis Severity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer

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