Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism

Marcos-Pasero, Helena; Aguilar-Aguilar, Elena; Iglesia, Rocío de la; Espinosa‐Salinas, Isabel; Gómez-Patiño, Mónica; Colmenarejo, Gonzalo; Molina, Ana Ramı́rez de; Reglero, Guillermo; Loria-Kohen, Viviana

doi:10.1016/j.clnu.2018.11.005

Cited by 15 publications

(13 citation statements)

References 38 publications

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“…Genotyping was performed at the GENYAL Platform (IMDEA‐Food, Madrid, Spain) using the OpenArray AccuFill System (Life Technologies Inc. Carlsbad, CA, USA) and the TaqMan Genotyper Software v1.3 (autocaller confidence level > 90%) for data analysis, as previously described. [ 38 ]…”

Section: Methodsmentioning

confidence: 99%

Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

Cortés‐Martín

Iglesias‐Aguirre

Meoro

et al. 2021

Molecular Nutrition Food Res

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Scope Poly‐pharmacological therapy shapes the gut microbiota (GM) in metabolic syndrome (MetS) patients. The effects of polyphenols in poly‐medicated MetS patients are unknown. Methods and results A randomized, placebo‐controlled, double‐blinded, and crossover trial in poly‐medicated MetS patients (n=50) explored whether the effects of a pomegranate extract nutraceutical (PE, 320 mg phenolics/day for 1 month) are affected by the drug therapy. Considering the lipid‐lowering (LL‐), anti‐hypertensive (HP‐) and(or) anti‐diabetic (AD‐) treatments: GM (16S rRNA sequencing), short‐chain fatty acids, 40 inflammatory‐metabolic and endotoxemia‐related biomarkers, associations between biomarkers and GM with 53 cardiometabolic dysfunctions‐related single‐nucleotide polymorphisms (SNPs), and urolithin metabotypes (UMs) influence are evaluated. Representative SNPs‐GM associations after PE include Lactococcus and ClostridiumXIVa with rs5443‐GNB3 (G‐protein‐β‐polypeptide‐3) and ClostridiumXIVa with rs7903146‐TCF7L2 (transcription‐factor‐7‐like‐2) and rs1137101‐LEPR (leptin‐receptor). PE decreases sICAM‐1 in LL‐patients and the lipopolysaccharide‐binding protein in all the patients. PE does not affect the other patients’ markers as a group or stratifying by UMs. After PE, Lactococcus increases in AD‐, LL‐, and HP‐patients, Bifidobacterium increases in LL‐ and AD‐, while Clostridium XIVa decreases in non‐LL‐ and non‐HP‐patients. Conclusion The prebiotic effect of PE depends on the medication, mainly on HP‐treatments. Targeting GM can complement MetS therapy, but the patients’ drug therapy should be considered individually.

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Section: Methodsmentioning

confidence: 99%

Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

Cortés‐Martín

Iglesias‐Aguirre

Meoro

et al. 2021

Molecular Nutrition Food Res

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“…The swabs were immediately stored in refrigeration and further frozen at −80 °C until their processing. Genomic DNA extraction and genotyping were carried out at the GENYAL Platform (IMDEA-Food, Madrid, Spain) using the OpenArray™ AccuFill™ System (Life Technologies Inc. Carlsbad, CA, USA) as described elsewhere 32 . Data analysis was made by TaqMan Genotyper Software v1.3 (autocaller confidence level > 90%).…”

Section: Methodsmentioning

confidence: 99%

Genetic Polymorphisms, Adherence to Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes: A Complex Cocktail to Predict the Obesity in Childhood-Adolescence

Cortés‐Martín¹,

Colmenarejo

Selma³

et al. 2019

Preprint

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Environmental and genetic factors are associated with pandemic obesity since childhood. However, the association of overweight-obesity with these factors, acting as a consortium, has been scarcely studied in children. We aimed here to assess the probabilities of being overweighed-obese in a randomly recruited cohort of Spanish children and adolescents (n=415, 5±17 years-old) by estimating the odds ratios for different predictor variables, and their relative importance in the prediction. The predictor variables were ethnicity, age, sex, adherence to the Mediterranean diet (KIDMED), physical activity, urolithin metabotypes (UM-A, UM-B, and UM-0) as biomarkers of the gut microbiota, and 53 single-nucleotide polymorphisms (SNPs) from 43 genes mainly related to obesity and cardiometabolic diseases. A proportional-odds logistic ordinal regression, validated through bootstrap, was used to model the data. While every variable was not independently associated with overweight-obesity, however, the ordinal logistic model revealed that overweight-obesity prevalence was related to being a young boy with either UM-B or UM-0, low KIDMED score and high contribution of a consortium of 24 SNPs, being rs1801253-ADRB1, rs4343-ACE, rs8061518-FTO, rs1130864-CRP, rs659366-UCP2, rs6131-SELP, rs12535708-LEP, rs1501299-ADIPOQ, rs708272-CETP and rs2241766-ADIPOQ the top-ten contributing SNPs. Additional research should confirm and complete this model by including dietary interventions and the individuals' gut microbiota composition.

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“…In addition, Precision Nutrition takes into account factors related to lifestyle such as diet, exercise, alcohol consumption, as well as the nutritional and metabolic status of the individuals [15,16]. In this regard, for example, several SNPs have been associated with obesity and muscle performance [17,18], and nutritional strategies based on the knowledge of the effect of bioactive compounds from natural sources such as plants, at the molecular level may contribute to restore the metabolic balance within individuals susceptible to develop chronic diseases [19,20].…”

Section: Introductionmentioning

confidence: 99%

Natural Extracts to Augment Energy Expenditure as a Complementary Approach to Tackle Obesity and Associated Metabolic Alterations

et al. 2021

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Obesity is the epidemic of the 21st century. In developing countries, the prevalence of obesity continues to rise, and obesity is occurring at younger ages. Obesity and associated metabolic stress disrupt the whole-body physiology. Adipocytes are critical components of the systemic metabolic control, functioning as an endocrine organ. The enlarged adipocytes during obesity recruit macrophages promoting chronic inflammation and insulin resistance. Together with the genetic susceptibility (single nucleotide polymorphisms, SNP) and metabolic alterations at the molecular level, it has been highlighted that key modifiable risk factors, such as those related to lifestyle, contribute to the development of obesity. In this scenario, urgent therapeutic options are needed, including not only pharmacotherapy but also nutrients, bioactive compounds, and natural extracts to reverse the metabolic alterations associated with obesity. Herein, we first summarize the main targetable processes to tackle obesity, including activation of thermogenesis in brown adipose tissue (BAT) and in white adipose tissue (WAT-browning), and the promotion of energy expenditure and/or fatty acid oxidation (FAO) in muscles. Then, we perform a screening of 20 natural extracts (EFSA approved) to determine their potential in the activation of FAO and/or thermogenesis, as well as the increase in respiratory capacity. By means of innovative technologies, such as the study of their effects on cell bioenergetics (Seahorse bioanalyzer), we end up with the selection of four extracts with potential application to ameliorate the deleterious effects of obesity and the chronic associated inflammation.

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Association of calcium and dairy product consumption with childhood obesity and the presence of a Brain Derived Neurotropic Factor-Antisense (BDNF-AS) polymorphism

Cited by 15 publications

References 38 publications

Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

Pharmacological Therapy Determines the Gut Microbiota Modulation by a Pomegranate Extract Nutraceutical in Metabolic Syndrome: A Randomized Clinical Trial

Genetic Polymorphisms, Adherence to Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes: A Complex Cocktail to Predict the Obesity in Childhood-Adolescence

Natural Extracts to Augment Energy Expenditure as a Complementary Approach to Tackle Obesity and Associated Metabolic Alterations

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