Association of C34TAMPD1gene polymorphism with features of metabolic syndrome in patients with coronary artery disease or heart failure

Abstract

C34T AMPD1 polymorphism may be associated with reduced frequency of obesity in CAD patients and of hyperglycaemia and diabetes in both CAD and HF patients. Morphometric parameters associated with adipose tissue distribution and parameters of glucose metabolism should be analysed as potential confounders in further studies on the role of polymorphisms of AMPD1 and other genes associated with AMP and adenosine metabolism in cardiovascular disease.

Association between the C34T polymorphism of the AMPD1 gene and essential hypertension in Malaysian patients

“…SBP was significantly lower in the CC carriers, in contrast to the results reported by Safranow et al (2009). In comparison with Safranow et al's study (2009) we detected 30 EH subjects who were carriers of the TT genotype.…”

“…The same outcomes were reported by Safranow et al (2009) using the same method (RFLP), with clear evidence from genotyping. Our results revealed that in the Malaysian population, the most common AMPD1 polymorphism (C34T) is strongly associated with EH (P ˂ 0.001).…”

“…In comparison with Safranow et al's study (2009) we detected 30 EH subjects who were carriers of the TT genotype. Moreover, Safranow et al (2009) reported no significant association between SBP and genotype, although DBP was higher in the CC genotype carriers than in the other subjects. In this study, we found a 2% AMPD1 deficiency in the CT (or heterozygous) genotype, which agrees with previous studies (Morisaki et al, 1992;Verzijl et al, 1998).…”

“…Following PCR, enzymatic digestion was carried out by RFLP to detect the C34T polymorphism in the second exon of AMPD1 based on the method reported previously (Safranow et al, 2009). The 119-bp PCR product was cleaved into 98 and 21 bp sequences in the presence of the normal fragment.…”

Gene Polymorphism and Coronary Heart Disease

“…Other obesity-related genes including ADIPOQ, leptin receptor, and fat mass obesity-related genes have also been described with respect to manifestation of metabolic syndrome and CAD/MI 90 . While genes, such as the PPARs 91 have been discussed as independent risk for CAD 88 , several of them may share common variants for metabolic syndrome with CAD/MI, among themselves and/or with others, including Ang II 92 , AMP deaminase-1 93 and ACE 91 genes. For example, the risk of acquiring CAD in patients with T2DM appears to increase significantly in the presence of the several gene variants such as those of the transcription factor 7-like 2 (TCF7L2) 94 and E-selectin genes 95 .…”