Association of C‐reactive protein and vitamin D deficiency with cardiovascular disease: A nationwide cross‐sectional study from National Health and Nutrition Examination Survey 2007 to 2008

Li, Qian; Dai, Zhenguo; Cao, Yuze; Wang, Lihua

doi:10.1002/clc.23189

Cited by 22 publications

(21 citation statements)

References 37 publications

(63 reference statements)

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“…Serum 25(OH)D levels were measured using blood samples collected from participants at mobile examination centers (MEC) through venipuncture according to the standard protocols. Detailed protocols used for sample processing and collection were reported previously (Li, Dai, Cao, & Wang, 2019). Serum 25(OH)D concentration was determined and analyzed at the National Center for Environmental Health Center for Disease Control and Prevention using a DiaSorin radioimmunoassay (Stillwater, MN).…”

Section: Methodsmentioning

confidence: 99%

“…Serum 25(OH)D concentration was determined and analyzed at the National Center for Environmental Health Center for Disease Control and Prevention using a DiaSorin radioimmunoassay (Stillwater, MN). The serum 25 (OH)D levels were classified as severely deficient (<25 nmol/ml), deficient (25–49.9 nmol/ml), insufficient (50–74.9 nmol/ml), and normal (≥75 nmol/ml) as previously described (Howe & Dellavalle, 2007;Li et al., 2019;Rosen, 2011).…”

Section: Methodsmentioning

confidence: 99%

“…The variable “family PIR” was calculated by dividing household income by the poverty guidelines (specific to family size) and the corresponding year and state, as described in previous studies (Bakhru & Erlinger, 2005;Ganji et al., 2018). The definition of smoking status was classified as “current smoking,” “former smoking,” and “never smoking,” which were defined based on answers from two questions: “Have you smoked at least 100 cigarettes in your life?” and “Do you now smoke cigarettes?” Alcohol consumption was defined as having at least 12 drinks of any type of alcoholic beverage in the past year (Eke et al., 2015;Li et al., 2019). Hypertension status was determined from the participants’ medical records: doctor's diagnosis or those using antihypertensive drugs.…”

Section: Methodsmentioning

confidence: 99%

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The association between serum 25‐hydroxyvitamin D levels and dental caries in US adults

Zhou

Shi

2020

Oral Diseases

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Objectives We investigated whether 25‐hydroxyvitamin D concentration is independently associated with dental caries among adults in the United States. Subjects and Methods This investigation was a cross‐sectional study. A total of 4,244 participants (aged 20–80 years) were enrolled through the 2007–2008 National Health and Nutrition Examination Survey (NHANES). Serum 25‐hydroxyvitamin D was categorized into four groups based on previous studies: normal (≥75 nmol/ml), insufficient (50–74.9 nmol/ml), deficient (25–49.9 nmol/ml), and severely deficient (<25 nmol/ml). The dependent and independent variables included dental caries and serum 25‐hydroxyvitamin D, respectively. The data were analyzed using univariate analyses, multivariable‐adjusted analyses, and subgroup analyses. Results The fully adjusted model showed that 25‐hydroxyvitamin D levels were negatively associated with dental caries after adjusting for the confounders (OR = 0.93, 95% CI 0.89 to 0.98). Compared with the normal group, the likelihood of dental caries was 2.48, 1.29, and 1.43 times higher in the severely deficient, deficient, and insufficient groups, respectively. Conclusions Our findings suggest that serum 25‐hydroxyvitamin D levels are significantly associated with the occurrence of dental caries among US adults.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The association between serum 25‐hydroxyvitamin D levels and dental caries in US adults

Zhou

Shi

2020

Oral Diseases

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“…This may be the reason for the simultaneous attenuation of CRP and inflammatory cytokines (CD4(+) IFN-γ) in hemodialysis patients after calcitriol treatment [19], or elevation of both CRP and cytokines in severe COVID-19 patients [23]. The relationship between CRP and Vit D has been investigated in multiple clinical studies and demonstrating an inverse correlation between the two variables [16,50]. In the following we investigate the link between CRP and Vit D among different age groups and among subjects with low-income and high-income.…”

Section: Crp and Vit D Deficiency In Healthy Subjectsmentioning

confidence: 99%

“…To the best of our knowledge, no randomized blinded experiment has yet reported Vit D status and cytokine levels in patients with COVID-19. In spite of this, it is still possible to investigate the association between Vit D status and unregulated inflammation and cytokine production leading to severe COVID-19 based on a potential link between Vit D deficiency and C-reactive proteins (CRP) [16].…”

Section: Introductionmentioning

confidence: 99%

The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients

Daneshkhah¹,

Agrawal²,

Eshein³

et al. 2020

Preprint

202

208

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Objectives To investigate the possible role of Vitamin D (Vit D) deficiency via unregulated inflammation in COVID-19 complications and associated mortality. Design The time-adjusted case mortality ratio (T-CMR) was estimated as the number of deceased patients on day N divided by the number of confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was further calculated as a metric of COVID-19 associated mortality in different countries. A model based on positivity change (PC) and an estimated prevalence of COVID-19 was developed to determine countries with similar screening strategies. Mean concentration of 25-hydroxyvitamin D (25(OH)D) in elderly individuals in countries with similar screening strategies were compared to investigate the potential impact of Vit D on A-CMR. We analyzed data showing a possible association between high C-Reactive Protein (CRP) concentration (CRP greater than or equal to 1 mg/dL) and severe COVID-19. We estimated a link between Vit D status and high CRP in healthy subjects (CRP greater than or equal to 0.2 mg/dL) with an adjustment for age and income to explore the possible role of Vit D in reducing complications attributed to unregulated inflammation and cytokine production. Data Sources Daily admission, recovery, and deceased rate data for patients with COVID-19 were collected from Kaggle as of April 20, 2020. Screening data were collected from Our World in Data and official statements from public authorities. The mean concentration of 25(OH)D among the elderly for comparison with A-CMR was collected from previously published studies from different countries. Chronic factor data used in regression analysis was obtained from published articles. The correlation between Vit D and CRP was calculated based on 9,212 subject-level data from NHANES, 2009-2010. Results A link between 25(OH)D and A-CMR in the US, France, Iran and the UK (countries with similar screening status) may exist. We observed an inverse correlation (correlation coefficient ranging from -0.84 to -1) between high CRP and 25(OH)D. Age and the family income status also correlated to high CRP and subjects with higher age and lower family income presented more incidences of high CRP. Our analysis determined a possible link between high CRP and Vit D deficiency and calculated an OR of 1.8 with 95%CI (1.2 to 2.6) among the elderly (age greater than or equal to 60 yo) in low-income families and an OR of 1.9 with 95%CI (1.4 to 2.7) among the elderly (age greater than or equal to 60 yo) in high-income families. COVID-19 patient-level data shows a notable OR of 3.4 with 95%CI (2.15 to 5.4) for high CRP in severe COVID-19 patients. Conclusion Given that CRP is a surrogate marker for cytokine storm and is associated with Vit D deficiency, based on retrospective data and indirect evidence we see a possible role of Vit D in reducing complications attributed to unregulated inflammation and cytokine storm. Further research is needed to account for other factors through direct measurement of Vit D levels in COVID-19 patients.

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Relationship between vitamin D deficiency and success of cardioversion in patients with atrial fibrillation

Fakhry

Ibrahim

2022

Herzschr Elektrophys

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Association of C‐reactive protein and vitamin D deficiency with cardiovascular disease: A nationwide cross‐sectional study from National Health and Nutrition Examination Survey 2007 to 2008

Cited by 22 publications

References 37 publications

The association between serum 25‐hydroxyvitamin D levels and dental caries in US adults

The association between serum 25‐hydroxyvitamin D levels and dental caries in US adults

The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients

Relationship between vitamin D deficiency and success of cardioversion in patients with atrial fibrillation

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