Association of Bruch’s membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma

Nakanishi, Hideo; Suda, K.; Yoshikawa, Munemitsu; Akagi, Tadamichi; Kameda, Takuro; Ikeda, Hanako Ohashi; Yokota, Satoshi; Kurimoto, Yasuo; Tsujikawa, Akitaka

doi:10.1007/s00417-017-3874-8

Cited by 13 publications

(10 citation statements)

References 52 publications

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“…A similar observation was reported by Nakanishi and colleagues. 32 The BMO diameters increased in the present study with longer axial length in a nonlinear manner. There was only a slight enlargement of the BMO with longer axial length in eyes with an axial length of 26.0 mm and a relatively steep and linear increase in eyes with an axial length of >26.0 mm (Figs.…”

Section: Discussionsupporting

confidence: 52%

Size and Shape of Bruch's Membrane Opening in Relationship to Axial Length, Gamma Zone, and Macular Bruch's Membrane Defects

Wei

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionsupporting

confidence: 52%

Size and Shape of Bruch's Membrane Opening in Relationship to Axial Length, Gamma Zone, and Macular Bruch's Membrane Defects

Wei

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Nakanishi et al . 15 also showed that BMO area was significantly associated with axial length. Our findings are consistent with those of previous reports, and indicate that BMO might undergo morphological changes during axial elongation.…”

Section: Discussionmentioning

confidence: 83%

“…In this study, a negative correlation was observed between BMO-MRW and BMO area. The dependency of BMO-MRW on BMO size is well known 6,14,15 . With a larger BMO area, the axons of RGCs spread over an increased perimeter, and therefore, the measured BMO-MRW seems to be diminished while still possessing the same number of axons.…”

Section: Discussionmentioning

confidence: 99%

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Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

Sung

Heo

et al. 2019

Sci Rep

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We examined the association between Bruch’s membrane opening (BMO) area and various ocular parameters and investigated the implication of BMO enlargement on the myopic optic nerve head. One hundred eighty-five myopic eyes were included in this cross-sectional study. Among the included eyes, 53 having axial lengths between 26 and 27 mm were further analyzed to investigate the association between BMO area and various ocular parameters. BMO area, BMO-minimum rim width (BMO-MRW), peripapillary choroidal thickness (pCT), width of β-parapapillary atrophy with and without Bruch’s membrane (PPA+BM and PPA−BM), and presence of lamina cribrosa (LC) defect were evaluated. We found that BMO area tended to increase with increasing axial length, but varied among the highly myopic eyes even though they had similar degrees of myopia. In the subgroup analysis of eyes with axial lengths between 26 and 27 mm, BMO area was highly variable and it significantly correlated with PPA−BM width and temporal-inferior, nasal-inferior, and nasal BMO-MRW and pCT. LC defects were more common in myopic eyes with enlarged BMO. A multivariate regression model revealed that higher intraocular pressure, enlarged BMO, and thinner BMO-MRW were associated with LC defects in highly myopic eyes. These findings should be considered when evaluating myopic eyes.

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“…It has been reported previously that optic disc features that are assessed two-dimensionally based on the clinical disc margin of optic disc photographs and three-dimensionally based on the BMO from OCT scans often do not agree (36). Based on measurements of fundus photographs relative to the clinical disc margin, myopic optic disks have been reported to have a more oval configuration (11, 18, 30-32, 34, 37), a higher degree of disc tilt (12, 13,18,30,[33][34][35] and rotation (11,12,18,31,34,35). The current study confirms greater ovality (lower ovality index) in eyes in the high axial myopia group compared to eyes in the no and mild axial myopia groups using both semi-automated photograph-and automated OCT measurements.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Optic Disc Ovality Index and Rotation Angle Measurements in Myopic Eyes Using Photography and OCT Based Techniques

Rezapour

Tran²,

Bowd³

et al. 2022

Front. Med.

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PurposeTo compare optic nerve head (ONH) ovality index and rotation angle measurements based on semi-automated delineation of the clinical ONH margin derived from photographs and automated BMO configuration derived from optical coherence tomography (OCT) images in healthy and glaucomatous eyes with high-, mild- and no axial myopia.MethodsOne hundred seventy-five healthy and glaucomatous eyes of 146 study participants enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS) with optic disc photographs and Spectralis OCT ONH scans acquired on the same day were stratified by level of axial myopia (non-myopic [n = 56, axial length (AL) <24 mm], mild-myopic [n = 58, AL 24–26 mm] and high-myopic [n = 32, AL >26 mm]. The clinical disc margin of each photograph was manually annotated, and semi-automated measurements were recorded of the ovality index and rotation angle based on a best-fit ellipse generated using ImageJ software. These semi-automated photograph-based measurements were compared to ovality index and rotation angle generated from custom automated BMO-based analysis using segmented OCT ONH volumes. R2 values from linear mixed effects models were used to describe the associations between semi-automated, photograph-based and automated OCT-based measurements.ResultsAverage (95% CI) axial length was 23.3 (23.0, 23.3) mm, 24.8 (24.7, 25.0) mm and 26.8 (26.6, 27.0) mm in non-myopic, mild-myopic and high-myopic eyes, respectively (ANOVA, p ≤ 0.001 for all). The R2 association (95% CI) between semi-automated photograph-based and automated OCT-based assessment of ONH OI for all eyes was [0.26 (0.16, 0.36); p < 0.001]. This association was weakest in non-myopic eyes [0.09 (0.01, 0.26); p = 0.02], followed by mild-myopic eyes [0.13 (0.02, 0.29); p = 0.004] and strongest in high-myopic eyes [0.40 (0.19, 0.60); p < 0.001]. No significant associations were found between photography- and OCT-based assessment of rotation angle with R2 values ranging from 0.00 (0.00, 0.08) in non-myopic eyes to 0.03 (0.00, 0.21) in high-myopic eyes (all associations p ≥ 0.33).ConclusionsAgreement between photograph-based and automated OCT-based ONH morphology measurements is limited, suggesting that these methods cannot be used interchangeably for characterizing myopic changes in the ONH.

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Association of Bruch’s membrane opening and optic disc morphology to axial length and visual field defects in eyes with primary open-angle glaucoma

Abstract: The optic disc ovality was associated with both the axial length and MD, whereas BMO ovality was not. Attention should be paid to the influence of the axial length-related enlargement of the BMO.

Cited by 13 publications

References 52 publications

Size and Shape of Bruch's Membrane Opening in Relationship to Axial Length, Gamma Zone, and Macular Bruch's Membrane Defects

Size and Shape of Bruch's Membrane Opening in Relationship to Axial Length, Gamma Zone, and Macular Bruch's Membrane Defects

Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

Comparison of Optic Disc Ovality Index and Rotation Angle Measurements in Myopic Eyes Using Photography and OCT Based Techniques

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