Association of breast cancer risk with polymorphisms in genes involved in the metabolism of xenobiotics and interaction with tobacco smoking: A gene‐set analysis

Berrandou, Takiy-Eddine; Mulot, Claire; Cordina‐Duverger, Emilie; Arveux, Patrick; Laurent‐Puig, Pierre; Truong, Thérèse; Guénel, Pascal

doi:10.1002/ijc.31917

Cited by 16 publications

(10 citation statements)

References 61 publications

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“… No. Gene Symbol Association with Gender Association with Smoking [ 61 ] 1 [ 62 ] [ 113 ] 2 [ 114 ] 3 [ 115 ] 4 [ 116 ] 5 [ 117 ] 5 [ 118 ] 5 [ 119 ] [ 120 ] Upregulated genes 1 CPT1A no no no no no no no no no no 2 GGT1 no no no no no no no no no no 3 …”

Section: Abdominal Aorta Aneurysm and Control Groups Constructionmentioning

confidence: 99%

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm

Zalewski

Ruszel

Stępniewski

et al. 2020

JCM

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Abdominal artery aneurysm (AAA) refers to abdominal aortic dilatation of 3 cm or greater. AAA is frequently underdiagnosed due to often asymptomatic character of the disease, leading to elevated mortality due to aneurysm rupture. MiRNA constitute a pool of small RNAs controlling gene expression and is involved in many pathologic conditions in human. Targeted panel detecting altered expression of miRNA and genes involved in AAA would improve early diagnosis of this disease. In the presented study, we selected and analyzed miRNA and gene expression signatures in AAA patients. Next, generation sequencing was applied to obtain miRNA and gene-wide expression profiles from peripheral blood mononuclear cells in individuals with AAA and healthy controls. Differential expression analysis was performed using DESeq2 and uninformative variable elimination by partial least squares (UVE-PLS) methods. A total of 31 miRNAs and 51 genes were selected as the most promising biomarkers of AAA. Receiver operating characteristics (ROC) analysis showed good diagnostic ability of proposed biomarkers. Genes regulated by selected miRNAs were determined in silico and associated with functional terms closely related to cardiovascular and neurological diseases. Proposed biomarkers may be used for new diagnostic and therapeutic approaches in management of AAA. The findings will also contribute to the pool of knowledge about miRNA-dependent regulatory mechanisms involved in pathology of that disease.

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Section: Abdominal Aorta Aneurysm and Control Groups Constructionmentioning

confidence: 99%

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm

Zalewski

Ruszel

Stępniewski

et al. 2020

JCM

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show abstract

“…A large pooled analysis showed that heavy smokers had higher estrogen and androgen levels, which may also contribute to cancer risk [102]. Single-nucleotide variants in genes involved in xenobiotics metabolism, which detoxify environmental pollutants such as those contained in tobacco smoke, may have a role in breast carcinogenesis [103].…”

Section: Cigarette Smokingmentioning

confidence: 99%

Effects of Major Lifestyle Factors on Breast Cancer Risk: Impact of Weight, Nutrition, Physical Activity, Alcohol and Tobacco

Vegunta

Lester

Pruthi

et al. 2020

Breast Cancer Manag.

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Breast cancer (BC) is the most commonly diagnosed cancer and second most common cause of cancer death in US women. Family history and genetics are well-known BC risk factors, but they only account for 15–20% of BC cases. Therefore, in addition to family history, healthcare providers must consider a woman’s modifiable and nonmodifiable personal risk factors that are associated with an increase in BC risk. The World Cancer Research Fund/American Institute for Cancer Research estimate that 30% of BC cases in the US are preventable. Lifestyle education is imperative given the magnitude of BC occurrence. Evidence supports prevention as an effective, long-term strategy for reducing risk. Healthcare providers are key stakeholders in empowering patients to adopt a healthy lifestyle for primary BC prevention. In this paper, we review the available evidence on modifiable BC risk including weight management, nutrition, physical activity, alcohol and tobacco use and provide strategies to counsel patients on lifestyle modifications.

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“…Some studies suggested that men were happier and lower levels of psychological stress when doing the housework such as cooking might make them nd the meaning and purpose of life [14,36]. In addition, most men's drinking and smoking behavior will affect the secretion and metabolism of hormone [37,38], thus overshadowing the effect of housework on human metabolism. The underlying mechanism between male housework and metabolism remains to be explored.…”

Section: Discussionmentioning

confidence: 99%

Gender differences in the relationships between housework and metabolic markers: a longitudinal cohort study in China

Wang¹,

Ren²,

Kou³

et al. 2020

Preprint

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Background: Metabolic syndrome has become a major health threat of the world, there are few studies focused on the effects of housework on human metabolism. The aims of this study were to explore the associations between housework and metabolic markers, and to examine whether there are gender differences in the relationships of housework intensity on metabolic markers.Methods: Using data of 2,624 participants were obtained from the China Health and Nutrition Survey. Binary logistic regression was used to analyze the associations between housework and metabolic markers (triglyceride, high- and low-density lipoprotein cholesterol, hemoglobin, blood glucose, cholesterol and blood pressure), with adjusting for the covariates.Results: No associations were observed between housework and metabolic markers for men. Women who engaged housework had a higher risk of triglycerides than non-housework (OR=1.16, 95%CI:1.16-4.25). Compared with the low-intensity, women with moderate- and high-intensity had a higher risk of triglycerides (OR=1.78, 95%CI:1.14-2.78; OR=1.91, 95%CI: 1.22-2.98), MetS (OR=1.54, 95%CI: 0.98-2.43; OR=1.68, 95%CI: 1.07-2.66), pre-hypertension (OR=1.68, 95%CI: 1.08-2.62; OR=1.63, 95%CI: 1.04-2.55) and overweight (OR=1.65, 95%CI: 1.01-2.70; OR=1.66, 95%CI: 1.01-2.72).Conclusion: Housework was associated with high levels of women’s metabolic markers such as triglycerides, MetS and pre-hypertension, and there were gender differences between the associations of housework intensity and metabolism markers. This may be a mechanism through which housework was associated with metabolic diseases.

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Association of breast cancer risk with polymorphisms in genes involved in the metabolism of xenobiotics and interaction with tobacco smoking: A gene‐set analysis

Cited by 16 publications

References 61 publications

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm

Dysregulation of microRNA Modulatory Network in Abdominal Aortic Aneurysm

Effects of Major Lifestyle Factors on Breast Cancer Risk: Impact of Weight, Nutrition, Physical Activity, Alcohol and Tobacco

Gender differences in the relationships between housework and metabolic markers: a longitudinal cohort study in China

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