Association of brain-derived neurotrophic factor and tyrosine kinase B receptor in pregnancy

Dhobale, Madhavi; Mehendale, Savita; Pisal, Hemlata; D'Souza, V; Joshi, Sadhana

doi:10.1016/j.neuroscience.2012.04.016

Cited by 27 publications

(30 citation statements)

References 34 publications

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“…Plasma and milk BDNF levels were measured using the BDNF Emax Immuno Assay System Promega kit (Hornbeck, 1994) and has been described by us earlier (Dhobale et al, 2012; Pillai et al, 2010). BDNF concentrations were expressed as pg/ml.…”

Section: Methodsmentioning

confidence: 99%

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Dangat

Kilari²,

Mehendale³

et al. 2013

Intl J of Devlp Neuroscience

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Children born to mothers with preeclampsia have consistently been suggested to be at risk for cognitive and behavioral disorders in later life. Breastfeeding is said to be associated with better neurodevelopment outcomes. Our earlier studies indicated higher levels of docosahexaenoic acid (DHA) in human milk in women with preeclampsia. DHA is known to regulate the expression of neurotrophins and together they play a vital role in neurodevelopment and cognitive performance. The present study examines the levels of maternal plasma and milk neurotrophins [(nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF)] in women with preeclampsia and compares them with normotensive women who served as controls. Singleton pregnant women diagnosed with preeclampsia (n=72) and controls (n=102) were recruited for this study from Bharati Hospital, Pune. Plasma and milk samples were analyzed for NGF and BDNF levels using the Emax Immuno Assay System using promega kits. Maternal plasma NGF and BDNF levels were lower (p<0.01 for both) in women with preeclampsia as compared to the control women. Milk NGF levels were similar while milk BDNF levels were higher (p<0.05) in the preeclampsia group as compared to controls. Plasma NGF levels were positively correlated with milk NGF levels in the control group. Our results indicate the differential regulation of milk NGF and BDNF levels in women with preeclampsia. The present study suggests a role for both NGF and BDNF in human milk for postnatal brain development. Further studies need to examine the associations of DHA and BDNF in human milk with cognition at later ages.

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Section: Methodsmentioning

confidence: 99%

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Dangat

Kilari²,

Mehendale³

et al. 2013

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…Further, there was a positive association of BDNF and NGF mRNA levels with the cord plasma BDNF and NGF levels suggesting that BDNF and NGF gene may reflect the BDNF and NGF protein since the cord plasma BDNF and NGF levels were lower in the preterm group (Dhobale et al, 2012b,c).…”

Section: Discussionmentioning

confidence: 99%

“…A total number of 38 women delivering preterm (<37 weeks gestation) and 37 women delivering at term (control group, =>37 weeks gestation) were recruited for this prospective study. The inclusion and exclusion criteria were as described in a series of our earlier studies in preterm deliveries (Dhobale et al, 2011, 2012a,b,c; Kilari et al, 2010; Joshi et al, 2008). Women were excluded from the study if there was evidence of other pregnancy complications like multiple gestation, pre‐eclampsia, chronic hypertension, type I or type II diabetes mellitus, seizure disorder, renal or liver disease.…”

Section: Methodsmentioning

confidence: 99%

Differential expression of human placental neurotrophic factors in preterm and term deliveries

Dhobale

Pisal

Mehendale

et al. 2013

Intl J of Devlp Neuroscience

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Neurotrophic factors such as brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in development of the placenta and fetal brain. A series of human and animal studies in our department have shown that micronutrients (folic acid, vitamin B12) and omega 3 fatty acids like DHA are all interlinked in the one carbon cycle. Any alterations in one carbon components will lead to changes in methylation patterns that further affect the gene expression at critical periods of development resulting in complications during pregnancy. This may further contribute to risk for neurodevelopmental disorders in children born preterm. Therefore this study for the first time examines the mRNA levels from preterm and term placentae. A total number of 38 women delivering preterm (<37 weeks gestation) and 37 women delivering at term (=>37 weeks gestation) were recruited. The mRNA levels of BDNF and NGF were analyzed by real time quantitative polymerase chain reaction. Our results indicate that BDNF and NGF mRNA levels were lower in preterm group as compared to term group. There was a positive association of placental BDNF and NGF mRNA levels with cord plasma BDNF and NGF levels. The differential expression of BDNF and NGF gene in preterm placentae may also alter the vascular development in preterm deliveries. Our data suggests that the reduced mRNA levels of BDNF and NGF may possibly be a result of altered epigenetic mechanisms and may have an implication for altered fetal programming in children born preterm.

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“…BNDF (brain-derived neurotrophic factor) and its receptor NTRK2 are expressed in the human placenta and regulate trophoblast growth (Dhobale et al, 2012). HGF (hepatocyte growth factor) M A N U S C R I P T…”

Section: Genes Involved In Placental Functionmentioning

confidence: 99%

The barrier, airway particle clearance, placental and detoxification functions of autism susceptibility genes

Carter

2016

Neurochemistry International

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Association of brain-derived neurotrophic factor and tyrosine kinase B receptor in pregnancy

Cited by 27 publications

References 34 publications

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Differential expression of human placental neurotrophic factors in preterm and term deliveries

The barrier, airway particle clearance, placental and detoxification functions of autism susceptibility genes

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