Association of bovine papillomavirus type-2 and urinary bladder tumours in cattle from Romania

Balcos, Liviu; Borzacchiello, Giuseppe; Russo, Valeria; Popescu, Oana; Roperto, Sante; Roperto, F.

doi:10.1016/j.rvsc.2007.10.002

Cited by 22 publications

(22 citation statements)

References 10 publications

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“…It is possible there exists geographic variations in the prevalence of BPV infection, however another possible explanation may be the variation in tumour collection methodology, since formaldehyde causes DNA denaturation and the lowest rates of detection are mostly detected in studies using tumours stored in formaldehyde. Our results respect to the E5 oncoprotein expression were in agreement with other reports (Balcos et al, 2008;Bohl et al, 2001;Borzacchiello et al, 2003).…”

supporting

confidence: 93%

Association of bovine papillomavirus type 2 (BPV-2) and urinary bladder tumours in cattle from the Azores archipelago

Resendes

Roperto²,

Trapani³

et al. 2011

Research in Veterinary Science

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a b s t r a c tUrinary bladder tumours in cattle are caused by chronic ingestion of bracken fern and BPV-1/2 infection. The objective of the present study was to assess if BPV-2 was present in urinary bladder lesions from cattle with chronic enzootic haematuria (CEH) from the Azores archipelago (Portugal), in order to gain further information regarding the epidemiologic distribution of this virus. Samples were analysed using PCR specific primers for BPV-2 DNA and an immunohistochemistry for BPV E5 oncoprotein detection. We found a 28% incidence rate of BPV-2 DNA in different types of tumours and cystitis cases (13 out of 46 samples). Tested positive samples for PCR were also positive for the viral E5 oncoprotein; protein immunolabeling was mainly detected within the cytoplasm of urothelial cells, displaying a juxtanuclear distribution. This is the first report of BPV-2 detection in urinary bladder tumours associated with CEH in cattle from the Azores archipelago.

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supporting

confidence: 93%

Association of bovine papillomavirus type 2 (BPV-2) and urinary bladder tumours in cattle from the Azores archipelago

Resendes

Roperto²,

Trapani³

et al. 2011

Research in Veterinary Science

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“…The analysis of naturally occurring cases of carcinomas from other countries (e.g. Romania) yielded similar findings, showing that BPV-2 DNA presence is not incidental and that the virus is widely spread in continental Europe [10]. BPV-2 E5 interacts with the PDGF receptor in both epithelial and vascular tumours of the urinary bladder, suggesting a possible role of the virus even in mesenchymal carcinogenesis [21,22].…”

Section: Bpv-1/2 and Urinary Bladder Tumoursmentioning

confidence: 53%

Bovine papillomaviruses, papillomas and cancer in cattle

Borzacchiello¹,

Roperto²

2008

Vet. Res.

169

149

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-Bovine papillomaviruses (BPV) are DNA oncogenic viruses inducing hyperplastic benign lesions of both cutaneous and mucosal epithelia in cattle. Ten (BPV 1-10) different viral genotypes have been characterised so far. BPV 1-10 are all strictly species-specific but BPV 1/2 may also infect equids inducing fibroblastic tumours. These benign lesions generally regress but may also occasionally persist, leading to a high risk of evolving into cancer, particularly in the presence of environmental carcinogenic co-factors. Among these, bracken fern is the most extensively studied. The synergism between immunosuppressants and carcinogenic principles from bracken fern and the virus has been experimentally demonstrated for both urinary bladder and alimentary canal cancer in cows whose diets were based on this plant. BPV associated tumours have veterinary and agricultural relevance in their own right, although they have also been studied as a relevant model of Human papillomavirus (HPV). Recent insights into BPV biology have paved the way to new fields of speculation on the role of these viruses in neoplastic transformation of cells other than epithelial ones. This review will briefly summarise BPV genome organization, will describe in greater detail the functions of viral oncoproteins, the interaction between the virus and co-carcinogens in tumour development; relevant aspects of immunity and vaccines will also be discussed.

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“…Chronic exposure to the fern has also been related in increases in bladder carcinomas characterized by hemorrhages in the organ (termed as bovine enzootic hematuria [BEH]) (Peixoto et al, 2003;Carvalho et al, 2006). Because it has been known for more than four decades that the presence of papillomas (live bovine papilloma virus [BPV] or as formalized vaccine) also gives rise to these same outcomes (Pamukcu et al, 1967), the immunosuppression we hypothesize here that is induced by fern intoxication could give rise to these particular cancers and the associated BEH (specifically, BPV-2: Campo et al, 1992;Campo, 1997;Balcos et al, 2008) as a result of these viruses being able to flourish. A similar immunomodulation-based scenario could be adapted to explain the reported increases in BPV-4-induced squamous cell carcinomas of the upper alimentary tract (Borzacchiello et al, 2003;Souto et al, 2006) in livestock that routinely consumed bracken fern.…”

Section: Introductionmentioning

confidence: 94%

Immunomodulatory effects ofPteridium aquilinumon natural killer cell activity and select aspects of the cellular immune response of mice

Latorre

Furlan

Sakai

et al. 2009

Journal of Immunotoxicology

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Association of bovine papillomavirus type-2 and urinary bladder tumours in cattle from Romania

Cited by 22 publications

References 10 publications

Association of bovine papillomavirus type 2 (BPV-2) and urinary bladder tumours in cattle from the Azores archipelago

Association of bovine papillomavirus type 2 (BPV-2) and urinary bladder tumours in cattle from the Azores archipelago

Bovine papillomaviruses, papillomas and cancer in cattle

Immunomodulatory effects ofPteridium aquilinumon natural killer cell activity and select aspects of the cellular immune response of mice

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