Association of bovine embryos produced by in vitro fertilization with a noncytopathic strain of bovine viral diarrhea virus type II

Bielański, A.; Sapp, Theresa M.; Lutze-Wallace, Cyril

doi:10.1016/s0093-691x(98)00070-3

Cited by 45 publications

(14 citation statements)

References 13 publications

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“…Although the vast literature concerning the contamination of the uterus and gametes of bovines by viruses as bluetongue virus (BTV), bovine leukaemia (BLV) and virus of the bovine viral diarrhea (BVDV) (7,8,9), this is the first report describing the presence of papillomavirus in these tissues and cells. Vanroose et al (10) suggested that the viruses can get the oocytes trough granulosa and cumulus cells although they have not discussed how the viruses can reach these cells.…”

Section: Discussionmentioning

confidence: 99%

Bovine papillomavirus type 2 in reproductive tract and gametes of slaughtered bovine females

Carvalho

Freitas

Brunner

et al. 2003

Braz. J. Microbiol.

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Papillomaviruses are described selectively infecting epithelial tissues and are associated with many forms of cancer in different species. Considering the widespread dissemination of papillomatosis in livestock, interest is being centred on possible forms of viral transmission and respective mechanisms. In the present study, we report the detection of bovine papillomavirus (BPV) DNA sequences in female reproductive tract tissues, fluids and oocytes from slaughtered bovines not afflicted by cutaneous papillomatosis. BPV-2 DNA sequences were found in ovarian and uterine tissues as well as in oocytes, cumulus cells and uterine flushings. The presence of papillomavirus sequences in reproductive organ tissues and fluids shows that viral infection in organisms can be verified in others tissues, not only in epithelial ones. The present findings alert to the possibility of BPV transmission in embryo transfer programs and assisted fertilization procedures.

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Section: Discussionmentioning

confidence: 99%

Bovine papillomavirus type 2 in reproductive tract and gametes of slaughtered bovine females

Carvalho

Freitas

Brunner

et al. 2003

Braz. J. Microbiol.

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“…Similarly, Bielanski and Dubuc (1995) using oocytes from acutely infected heifers (BVDV I; NY‐1) in an in vitro production system showed that COC, granulosa cells and follicular fluid were positive for virus, but the UTC and in vitro ‐derived embryos were negative for virus. However, the UTC and in vitro ‐derived embryos were positive for virus when acutely infected heifers were infected with a different strain of BVDV (BVDV II; CD‐87) (Bielanski et al. 1998).…”

Section: Discussionmentioning

confidence: 99%

Amplification of Bovine Viral Diarrhoea Virus Introduced into an In Vitro Embryo Production System Via Oocytes from Persistently Infected Cattle

Marley

Givens

Galik

et al. 2009

Reprod Domestic Animals

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The purpose of this study was to determine whether or not embryos derived from in vitro fertilization of oocytes from persistently infected (PI) cattle would contain infectious virus.Three in vitro embryo production treatment groups were assessed: 1) oocytes and uterine tubal cells (UTC) free of bovine viral diarrhoea virus (BVDV) (negative control), 2)oocytes free of BVDV fertilized and cultured in media containing UTC obtained from PI heifers, and 3) oocytes from PI heifers fertilized and cultured in media containing UTC free of BVDV. The developmental media, UTC and embryos (individual or groups of five) were assayed for virus.Virus was not isolated from any samples in treatment group 1.As shown in previous studies, a proportion of embryo samples were positive for BVDV in treatment group 2. In treatment group 3, the virus associated with the oocytes contaminated the developmental media and infected susceptible co-culture cells used during fertilization and culture. In addition, 65% (11/17) of the degenerated ova from treatment group 3 had infectious virus associated with them. While none of the ova developed into transferable embryos, the study did confirm that use of oocytes from PI cows could lead to amplification of BVDV and cross contamination during in vitro embryo production.

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“…140,150 Infection with BVDV was demonstrated in oviductal cells following intravenous inoculation with noncytopathic BVDV and intrauterine infection with cytopathic BVDV resulting in salpingitis for 21 days. 151,152 In uterine flushes from a subset of experimentally infected heifers, BVDV was isolated on days 8 and 16 following infection with BVDV, demonstrating a potential risk for the developing embryo in the uterine environment. 152 Widespread BVDV infection of the reproductive system and reduced reproductive performance are described in PI cattle.…”

Section: Postnatal Infections In Immunocompetent Cattlementioning

confidence: 99%

“…151,152 In uterine flushes from a subset of experimentally infected heifers, BVDV was isolated on days 8 and 16 following infection with BVDV, demonstrating a potential risk for the developing embryo in the uterine environment. 152 Widespread BVDV infection of the reproductive system and reduced reproductive performance are described in PI cattle. Extensive BVDV immunostaining and pathoanatomical abnormalities including significantly reduced follicular structures and ovarian and follicular hypoplasia were described in PI cows.…”

Section: Postnatal Infections In Immunocompetent Cattlementioning

confidence: 99%

Infectious Agents

Passler

2014

Bovine Reproduction

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Association of bovine embryos produced by in vitro fertilization with a noncytopathic strain of bovine viral diarrhea virus type II

Cited by 45 publications

References 13 publications

Bovine papillomavirus type 2 in reproductive tract and gametes of slaughtered bovine females

Bovine papillomavirus type 2 in reproductive tract and gametes of slaughtered bovine females

Amplification of Bovine Viral Diarrhoea Virus Introduced into an In Vitro Embryo Production System Via Oocytes from Persistently Infected Cattle

Infectious Agents

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