Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort

Hassiotis, Angela; Brown, Emma; Harris, James; Helm, David; Munir, Kerim; Salvador‐Carulla, Luis; Bertelli, Marco O.; Baghdadli, Amaria; Wieland, Jannelien; Novell-Alsina, Ramon; Cid, Jordi; Vergés, Laura; Martínez‐Leal, Rafael; Mutluer, Tuba; Ismayilov, Fuad; Emerson, Eric

doi:10.21203/rs.2.12938/v3

Cited by 1 publication

(2 citation statements)

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“…The finding that environmental influences on negative affect are moderated by intelligence indicates that environmental influences play a greater role in the development of anxiety-related disorders in individuals with below-average intelligence than they do in individuals with (above) average intelligence. This is in line with the mechanism depicted in Figures 1B, which describes that individuals with intellectual disabilities are at greater risk for traumatizing life events and subsequently have a greater risk of developing psychopathology (Hassiotis et al 2019;Smith et al 2021).…”

Section: Discussionsupporting

confidence: 85%

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Are genetic and environmental risk factors for psychopathology amplified in children with below-average intelligence? A population-based twin study.

Bruins

Bergen²,

Masselink³

et al. 2022

Preprint

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There is a negative association between intelligence and psychopathology, implying that individuals with intellectual disability are at greater risk for psychopathology. We analyzed data on intelligence and psychopathology in seven-year-old twin pairs (npairs ≥ 616) to determine the degree to which genetic and environmental factors common to intelligence and psychopathology explain the association, and to examine whether genetic and environmental effects on psychopathology are moderated by intelligence. We found that intelligence correlated negatively with internalizing, externalizing, and neurodevelopmental psychopathology. The associations were mainly due to common genetic factors. Intelligence moderated genetic and environmental effects on internalizing psychopathology (anxiety and negative affect), but not those on externalizing and neurodevelopmental psychopathology. The heritability of anxiety and negative affect was greatest in individuals with below-average intelligence. We discuss mechanisms through which this effect could arise, and we end with some recommendations for future research.

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Section: Discussionsupporting

confidence: 85%

“…Second, there is evidence that individuals with below-average intelligence are at increased risk for exposure to adverse experiences in childhood (Hassiotis et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Are genetic and environmental risk factors for psychopathology amplified in children with below-average intelligence? A population-based twin study.

Bruins

Bergen²,

Masselink³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort

Abstract: Background : To examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood

Cited by 1 publication

References 35 publications

Are genetic and environmental risk factors for psychopathology amplified in children with below-average intelligence? A population-based twin study.

Are genetic and environmental risk factors for psychopathology amplified in children with below-average intelligence? A population-based twin study.

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