Association of bone mineral density and diabetic retinopathy in diabetic subjects: the 2008–2011 Korea National Health and Nutrition Examination Survey

Lim, Young Wook; Chun, Sang Hoon; Lee, J. H.; Baek, Ki Hyun; Lee, W. K.; Yim, Hyeon Woo; Kang, Moo Il

doi:10.1007/s00198-016-3527-5

Cited by 24 publications

(18 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The KNHANES consists of three components: a health interview, a nutrition survey, and a health examination. Until the first half of 2008, data were gathered through household interviews and direct standardized physical examinations conducted at simple checkup centers at city government offices and town halls [ 14 ]. From the second half of 2008 to 2011, the survey was conducted by introducing mobile inspection vehicles.…”

Section: Methodsmentioning

confidence: 99%

Effect of duration of diabetes on bone mineral density: a population study on East Asian males

Jang

Kim²,

Lea³

et al. 2018

BMC Endocr Disord

View full text Add to dashboard Cite

BackgroundThe aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011.MethodsIn total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 3383 males aged ≥50 years were eligible. They underwent BMD measurement through dual-energy X-ray absorptiometry (DXA). The fasting plasma glucose and insulin levels of participants were also measured.ResultsMen with prediabetes and diabetes had significantly higher mean BMD at all measured sites than control men did, irrespective of DM status. This was confirmed by multivariable linear regression analyses. DM duration was an important factor affecting BMD. Patients with DM for > 5 years had lower mean BMD in the total hip and femoral neck than those with DM for ≤5 years. Per multivariable linear regression analyses, patients with DM for > 5 years had significantly lower mean BMD at the femoral neck than those with DM ≤5 years.ConclusionsDM duration was significantly associated with reduced femoral neck BMD.

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of duration of diabetes on bone mineral density: a population study on East Asian males

Jang

Kim²,

Lea³

et al. 2018

BMC Endocr Disord

View full text Add to dashboard Cite

show abstract

“…3 4 DR has been considered to be correlated with many other diabetes-related complications, such as nephropathy, peripheral neuropathy, low bone density and cardiovascular events, all of which lower the quality of life and produce a high rate of mortality. [5][6][7][8] Therefore, early diagnosis and proper management of DR would be of great significance.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of diabetic retinopathy and sight-threatening diabetic retinopathy: a cross-sectional study of 13 473 patients with type 2 diabetes mellitus in mainland China

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo explore the risk factors of diabetic retinopathy (DR) and sight-threatening diabetic retinopathy (STDR) among Chinese patients with diabetes.Design, setting and participantsA cross-sectional investigation was performed in eight screening clinics in six provinces across mainland China. Information about the risk factors was recorded in screening clinics. Some risk factors (sex, age, diagnosis age, diabetes duration, systolic blood pressure (SBP), diastolic blood pressure, fasting blood glucose (FBG) and glycosylated haemoglobin (HbA1c)) were recorded in all eight clinics, while others were collected only in a subset of the clinics. The relationships between the risk factors and DR and between the risk factors and STDR were explored for the eight factors mentioned above and for all factors studied.Main outcomes and measuresRisk factors of DR and STDR were assessed, and a nomogram of the results was produced.ResultsYounger age, longer diabetes duration, higher SBP, higher FBG and higher HbA1c were found to be independent risk factors for both DR and STDR in the eight-factor analyses. In the all-factor analysis, younger age, longer diabetes duration, higher SBP, oral medicine use and insulin use were independent risk factors for both DR and STDR; higher postprandial blood glucose (PBG), HbA1c, triglyceride andlow-density lipoprotein were independent risk factors for DR only, and higher FBG was a risk factor for STDR only.ConclusionsIn this cross-sectional investigation, several risk factors were found for DR and STDR. Notably, FBG, PBG and HbA1c were all risk factors for DR or STDR, suggesting that stricter blood glucose control in clinical practice is required.

show abstract

“…A few studies have addressed the association of chronic complications of T2D with reduced BMD. They have reported decreased BMD in patients with neuropathy [4, 5], retinopathy [6] and also in patients with early-stage of diabetic chronic kidney disease [7]. Recent studies have demonstrated that diabetes may adversely influence the bone quality through the regulation of bone cells [8].…”

Section: Introductionmentioning

confidence: 99%

The association between bone turnover markers and microvascular complications of type 2 diabetes

Maghbooli

Shabani

Gorgani‐Firuzjaee

et al. 2016

J Diabetes Metab Disord

View full text Add to dashboard Cite

BackgroundGlobal epidemic of diabetes is a serious health care concern because of its complications and consequently reduced life expectancy and increased morbidity. However, the bone turnover and thus bone health may be affected or even compromised by diabetes and its complications. The aim of this study was to assess whether bone turnover markers are associated with diabetes micro-vascular complications.MethodsA total of 204 type 2 diabetes patients (104 patients with diabetic micro-vascular complications (retinopathy and/or nephropathy) as a case group and 100 patients without retinopathy and/or nephropathy) as a control group were recruited in this case–control study. The biochemical and metabolic parameters and bone turnover markers were assessed in all patients.ResultsOur findings showed serum levels of osteocalcin (OC) (p = 0.0001) and, carboxy-terminal collagen crosslinks (CTX) (p = 0.006) were higher in diabetic patients with both diabetic retinopathy and nephropathy compared with control group. However, there was no significant difference in serum levels of procollagen I aminoterminal propeptide (P1NP) between diabetic patients with diabetic retinopathy (DR) and/or diabetic nephropathy (DN) compared with control.In diabetes patients with complications, there were significant negative correlation between OC and CTX with estimated-glomerular filtration rate (e-GFR) and also positive correlation between each bone marker (OC and CTX) and PTH levels (p = 0.0001) and BUN (p = 0.0001).In a general linear model, after adjusting for age, sex and BMI, and microvascular complications, there was not any significant association between three bone turnover markers and metabolic markers including fasting glucose, insulin, and lipid profile. Among kidney markers, there were significant positive associations between serum levels of CTX and OC with BUN (p < 0.05) as well as PTH (p < 0.0001).ConclusionsOur data suggest the possible role of PTH and BUN levels in modulating bone turnover markers in diabetic patients.

show abstract

Association of bone mineral density and diabetic retinopathy in diabetic subjects: the 2008–2011 Korea National Health and Nutrition Examination Survey

Abstract: This study has shown that the presence of diabetic retinopathy is significantly associated with a reduced BMD and increased prevalence of osteoporosis in diabetic women.

Cited by 24 publications

References 34 publications

Effect of duration of diabetes on bone mineral density: a population study on East Asian males

Effect of duration of diabetes on bone mineral density: a population study on East Asian males

Risk factors of diabetic retinopathy and sight-threatening diabetic retinopathy: a cross-sectional study of 13 473 patients with type 2 diabetes mellitus in mainland China

The association between bone turnover markers and microvascular complications of type 2 diabetes

Contact Info

Product

Resources

About