Association of bone marrow edema with temporomandibular joint (TMJ) osteoarthritis and internal derangements

Wahaj, Aiyesha; Hafeez, Kashif; Zafar, Muhammad Sohail

doi:10.1080/08869634.2016.1156282

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…TMD is a complex multifactorial condition that may be initiated by factors such as malocclusion, parafunctional habits (lip biting, bruxism) 31 and psychological factors, including anxiety or stress 31, 32, 33. Stress and parafunctional habits are well known factors that are associated with TMD symptoms in university students 15, 31.…”

Section: Discussionmentioning

confidence: 99%

Self-reported frequency of temporomandibular disorders among undergraduate students at Taibah University

Zafar

Fareed

Taymour

et al. 2017

Journal of Taibah University Medical Sciences

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Objectives This study aimed to evaluate the prevalence and severity of temporomandibular joint (TMJ) disorders among undergraduate students. In addition, the severity of TMD was examined in terms of its relationship with gender, age and field of study. Methods A total of 439 undergraduate students of both genders (age range: 20–27 years) who were studying at various colleges at Taibah University were invited to participate in this study. Each student was provided with a questionnaire, and the significance and purpose of the study were explained. The data were collected using Fonseca's questionnaire, an instrument that assessed the demographic characteristics of the students and included ten key questions. The severity of TMD was categorized as no, mild, moderate or severe. The data were analysed using SPSS Version 22 (IBM, Illinois, USA). The chi-square test was used to compare the data from different groups and to determine whether the differences were statistically significant. Results Of those who were invited, 78 students did not return the questionnaires, whereas another 11 were excluded due to their submitting an incomplete questionnaire. A majority of the students reported no TMD (46.7%) or mild TMD (42.7%). A moderate level of TMD was reported by 8.8% of students. Only 1.7% of students reported severe TMD. No significant differences were observed in the severity of TMD in terms of student age or field of study. Conclusion TMD is more prevalent among female students than male students. However, its occurrence is not affected by the age and field of study of the student.

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Section: Discussionmentioning

confidence: 99%

Self-reported frequency of temporomandibular disorders among undergraduate students at Taibah University

Zafar

Fareed

Taymour

et al. 2017

Journal of Taibah University Medical Sciences

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“…A clear connection between joint effusion and osteoarthritis of the temporomandibular joint [16] and between joint effusion and disc displacement (particularly without repositioning in a functional position) was seen [17]. There was also a close connection between joint effusion and bone marrow edema in the capitulum in clinical pain syndrome [18]. A further MRI study in CMD patients (unsurprisingly) showed a clear statistical relationship between anterior disc dislocation seen on MRI, osteoarthritis, bone marrow edema, and joint effusion and a clinically manifested pain syndrome [19].…”

Section: Discussionmentioning

confidence: 89%

What Role Does Synovitis Play in Craniomandibular Dysfunction (CMD)? A 3T-MRI Study

Stimmer

Ritschl

Goetz

et al. 2019

Fortschr Röntgenstr

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Purpose The purpose of the present study was to investigate the degree and clinical relevance of synovitis in craniomandibular dysfunction. Materials and Methods In total, 140 temporomandibular joints were examined using a 3 T MRI scanner. Quantitative analysis of synovial enhancement was performed and interrelated with arthrosis deformans, degenerative disc disease, joint effusion, bone marrow edema and restriction of motion. Results We found a statistically high and significant correlation between the degenerative changes as mentioned above and the intensity of synovial enhancement. Conclusion The study shows that typical MRI findings in CMD patients are often combined with signs of synovitis. Presumably joint inflammation has an effect on the clinical signs and symptoms and also the prognosis of CMD. These results should be taken into consideration when selecting treatment. Key Points: Citation Format

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“…Interestingly, these data are in line with observations of human patients, who sometimes display such variability in synovial fluid volume. [33][34][35] Because FLSs are active players that contribute to cartilage damage in RA, we considered their potential role in the erosive process observed in the TMJ of K/BxN mice. We obtained and cultured primary FLSs from TMJs by using a protocol adapted from one that is usually used in our laboratory to harvest FLSs from limb joints.…”

Section: Discussionmentioning

confidence: 99%

Temporomandibular joint damage in K/BxN arthritic mice

et al. 2020

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Rheumatoid arthritis (RA) is an autoimmune disease affecting 1% of the world population and is characterized by chronic inflammation of the joints sometimes accompanied by extra-articular manifestations. K/BxN mice, originally described in 1996 as a model of polyarthritis, exhibit knee joint alterations. The aim of this study was to describe temporomandibular joint (TMJ) inflammation and damage in these mice. We used relevant imaging modalities, such as micro-magnetic resonance imaging (μMRI) and micro-computed tomography (μCT), as well as histology and immunofluorescence techniques to detect TMJ alterations in this mouse model. Histology and immunofluorescence for Col-I, Col-II, and aggrecan showed cartilage damage in the TMJ of K/BxN animals, which was also evidenced by μCT but was less pronounced than that seen in the knee joints. μMRI observations suggested an increased volume of the upper articular cavity, an indicator of an inflammatory process. Fibroblast-like synoviocytes (FLSs) isolated from the TMJ of K/BxN mice secreted inflammatory cytokines (IL-6 and IL-1β) and expressed degradative mediators such as matrix metalloproteinases (MMPs). K/BxN mice represent an attractive model for describing and investigating spontaneous damage to the TMJ, a painful disorder in humans with an etiology that is still poorly understood.

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Association of bone marrow edema with temporomandibular joint (TMJ) osteoarthritis and internal derangements

Cited by 16 publications

References 41 publications

Self-reported frequency of temporomandibular disorders among undergraduate students at Taibah University

Self-reported frequency of temporomandibular disorders among undergraduate students at Taibah University

What Role Does Synovitis Play in Craniomandibular Dysfunction (CMD)? A 3T-MRI Study

Temporomandibular joint damage in K/BxN arthritic mice

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