Association of body size and fat distribution with risk of breast cancer among Chinese women

Shu, Xiao‐Ou; Jin, Fan; Dai, Qi; Shi, Jian Rong; Potter, John D.; Brinton, Louise A.; Hébert, James R.; Ruan, Zhi; Gao, Yu‐Tang; Wang, Zheng

doi:10.1002/ijc.1487

Cited by 97 publications

(82 citation statements)

References 45 publications

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“…3,12,14,15,23 WHR was not related to risk of postmenopausal breast cancer in our study, whereas other studies reported a positive relation, with recent studies 12,14,15,23 reporting a stronger relation than earlier ones, reviewed by Friedenreich. 3 Huang et al 24 studied the independent effect of anthropometric measurements, with and without adjustment for BMI.…”

Section: Discussioncontrasting

confidence: 93%

“…2,3,12,13,14 Our results of a decrease in risk of premenopausal breast cancer with increasing thorax and waist circumferences are in agreement with previous studies. 2,12,15 The decrease in risk observed with increasing WHR is in disagreement with past studies and reviews, 3,6,12,[15][16][17] which found a possible increase in risk of premenopausal breast cancer with increasing WHR. The highest increase in risk was observed in Männistö's analysis of a case-control study, with an RR of 4.6 (2.0-10.7) for women with a WHR greater than 0.87 compared with those with a WHR less than 0.78.…”

Section: Discussionsupporting

confidence: 93%

“…Among premenopausal women, our estimate of a negative relation between weight, BMI and breast cancer was similar to that of the Pooling Project on Diet and Cancer. 2 Other results from recent case-control studies on populations of various ethnic origins 3,12,13 were closer to unity. However, in case-control studies, because controls usually have many nonparticipants, those who are most obese are likely to be less represented.…”

Section: Discussionmentioning

confidence: 77%

“…The increase in breast cancer risk with increasing height is in agreement with the RRs reported in a meta-analysis of seven cohort studies, the Pooling Project on Diet and Cancer. 2 Three recent casecontrol studies on Asian populations [10][11][12] showed an increased risk of premenopausal breast cancer among taller women (over approximately 160 cm). Among postmenopausal women, previous studies reported evidence of a positive association between height and breast cancer risk, 2,3,10,12 with RRs of between 1.3 and 1.9 for taller women compared with shorter women.…”

Section: Discussionmentioning

confidence: 99%

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Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Téhard

Clavel‐Chapelon

2005

Int J Obes

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Objective: To investigate the association between various anthropometric characteristics and breast cancer. Design: Longitudinal prospective cohort study. Follow-up between 1995 and 2000. Subjects: In total, 69 116 women (age: 45-70 years; mean follow-up: 3.6 years), 275 premenopausal and 860 postmenopausal incident invasive breast cancers. Measurements: Self-reported height, weight, breast, thorax, waist and hip circumferences and calculated body mass index (BMI) and waist-to-hip ratio (WHR) at baseline. Results: A slight increase in risk with increasing height was found. Weight, BMI, thorax and waist circumferences and WHR were negatively related to breast cancer risk among premenopausal women. The relationships became non significant after additional adjustment for BMI. An increased risk of premenopausal breast cancer with an android body shape (WHR40.87) might possibly be confined to obese women. Among postmenopausal women, all anthropometric measurements of corpulence were positively associated with breast cancer risk but became non significant after additional adjustment for BMI. No difference in risk of postmenopausal breast cancer according to HRT use was observed.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Téhard

Clavel‐Chapelon

2005

Int J Obes

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“…In a previous analysis of this study, premenopausal breast cancer was unrelated to early adult and adult weight, but was associated with a high adult waist-to-hip ratio, even after adjustment for body mass index (Shu et al, 2001). These findings differ from the majority of studies of this topic conducted among Western women.…”

Section: Epidemiologycontrasting

confidence: 98%

Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population

et al. 2002

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We assessed breast cancer risk in relation to weight at birth and adolescence. In-person interviews were completed with the biological mothers of women aged 45 years and younger who participated in the Shanghai Breast Cancer Study in 1996 -98 (288 cases, 350 controls). After adjustment for confounding, women who were 4000 g or more at birth were not at increased risk of breast cancer (odds ratio=0.7; 95% confidence interval 0.4 -1.4) relative to women whose birth weight was 2500 -2999 g. Compared with women of average perceived weight at age 15 years, no relation was apparent for heavier than average weight based on maternal report (odds ratio=0.7; 95% confidence interval 0.5 -1.2) or self-report (odds ratio=1.0; 95% confidence interval 0.7 -1.6). Perceived adolescent weight and height did not modify the association of birth weight with breast cancer risk. These results suggest that weight early in life is not related to premenopausal breast cancer risk in this low-risk population. (Ekbom et al, 1992;Innes et al, 2000;Michels et al, 1996;Sanderson et al, 1996). Conversely, high adolescent (Coates et al, 1999;Hislop et al, 1986;Le Marchand et al, 1988a), early adult (Coates et al, 1999;Huang et al, 1997;Trentham-Dietz et al, 1997) and adult weight or body mass index (Brinton and Swanson, 1992;Huang et al, 1997;Swanson et al, 1996;Ursin et al, 1995;van den Brandt et al, 2000) appear to be protective against premenopausal breast cancer. Several studies have investigated the association between breast cancer and weight at birth (De Stavola et al, 2000;Ekbom et al, 1992Ekbom et al, , 1997Innes et al, 2000;Le Marchand et al, 1988b;Michels et al, 1996;Sanderson et al, 1996Sanderson et al, , 1998a or weight at adolescence (Brinton and Swanson, 1992;Choi et al, 1978;Coates et al, 1999;Franceschi et al, 1996;Hislop et al, 1986;Le Marchand et al, 1988a;Pryor et al, 1989) with inconsistent findings. Possible limitations of these studies related to exposure measurement and age at diagnosis of breast cancer.Since self-report of body size in early life is prone to misclassification, maternal report may be less subjective. Maternal report was available for two of the studies investigating breast cancer risk associated with birth weight (Michels et al, 1996;Sanderson et al, 1998a), but none of the studies of adolescent weight. The present analysis was conducted to assess whether birth weight and adolescent weight as reported by subjects' mothers were related to premenopausal breast cancer risk. In addition, we investigated whether perceived adolescent weight and height modified the association of birth weight with breast cancer risk. MATERIALS AND METHODSDetailed methods of this population-based case -control study appear elsewhere (Gao et al, 2000). Briefly, all women aged 25 -64 years who were permanent residents of urban Shanghai at the time of diagnosis of first primary invasive breast cancer (August 1996 through March 1998) were eligible for the study. Two senior pathologists histologically confirmed all diagnoses. We used...

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Longitudinal Study on the Role of Body Size in Premenopausal Breast Cancer

Michels

Terry²,

Willett³

2006

Arch Intern Med

142

131

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Background: A high body mass index (BMI) has been related to a reduced risk of breast cancer in premenopausal women. The mechanisms underlying this association have not been elucidated. Methods: We explored whether factors affecting ovulation may explain the inverse association between BMI (calculated as weight in kilograms divided by the square of height in meters) and breast cancer in 113 130 premenopausal participants in the Nurses' Health Study II. During 1 225 520 person-years of prospective follow-up between 1989 and 2003, 1398 incident cases of invasive breast cancer were diagnosed. Weight, height, ovulatory infertility, menstrual cycle patterns, and a multitude of covariates were assessed throughout follow-up. Cox proportional hazards regression was used to compute hazard ratios and 95% confidence intervals (CIs). Results: We observed a significant linear inverse trend between current BMI and breast cancer incidence (PϽ.001) that was not explained by menstrual cycle characteristics or infertility due to an ovulatory disorder (covariate-adjusted hazard ratio for breast cancer in women with a BMI Ն30 vs 20.0-22.4, 0.81; 95% CI, 0.68-0.96). We found BMI at age 18 years to be the strongest predictor of breast cancer incidence (covariate-adjusted hazard ratio for breast cancer in women with a BMI at age 18 years Ն27.5 vs 20.0-22.4, 0.57; 95% CI, 0.41-0.81). Conclusions: Body size during the early phases of adult life seems to be particularly important in the development of premenopausal breast cancer. Factors other than anovulation are likely to mediate the protection conferred by a high BMI.

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Association of body size and fat distribution with risk of breast cancer among Chinese women

Cited by 97 publications

References 45 publications

Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population

Longitudinal Study on the Role of Body Size in Premenopausal Breast Cancer

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