Association of body mass index and blood pressure variability with 10-year mortality and renal disease progression in type 2 diabetes

Abstract

Background Variability in biological parameters may be associated with adverse outcomes. The aim of the study was to determine whether variability in body mass index (BMI) and blood pressure is associated with all-cause, cardiovascular mortality and cancer mortality or with renal disease progression in subjects with type 2 diabetes. Methods The diabetes database was accessed, and all the information on patient visits (consultations) carried out in the study period (1 January 2008–31 December 2019) was extracted and linked to the laboratory database and the mortality register. Results The total number of patients included in the study population was 26,261, of whom 54.4% were male. Median (interquartile range, IQR) age was 60.2 (51.8–68.3) years. The coefficient of variability of BMI was independently associated with increased all-cause and cardiovascular, but not cancer, mortality. Glycated haemoglobin (HbA1c) was associated with increased all-cause, cardiovascular, and cancer mortality as well as with renal progression. Variability in systolic blood pressure, diastolic blood pressure, and pulse pressure was associated with increased all-cause and cardiovascular mortality in bivariate, but not in multivariate, analyses. Conclusions Variability in BMI was associated with increased all-cause and cardiovascular, but not cancer, mortality in a large real-world contemporary population. Our results also confirm the association of HbA1c with increased all-cause, cardiovascular, and cancer mortality as well as with renal progression.

Relationship between 24 h blood pressure variability and mortality in acute myocardial infarction patients

“… 18 , 19 However, emerging evidence suggests that BPV is independently associated with target organ damage, cardiovascular events, and risk of death in patients without hypertension, including those with diabetes, chronic kidney disease, and obstructive sleep apnea. 20 , 21 , 22 , 23 In recent years, the relationship between BPV and the prognosis of patients with AMI has garnered attention.…”