Association of body mass index with embryonic aneuploidy

Goldman, Kara N.; Hodes-Wertz, B.; McCulloh, David H.; Flom, Julie D.; Grifo, James A.

doi:10.1016/j.fertnstert.2014.11.029

Cited by 61 publications

(35 citation statements)

References 33 publications

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“…Whether obesity has a negative effect on implantation and postimplantation events and on oocyte and embryo quality remains uncertain. Although euploidy rate and BMI were not found to be related in a recent retrospective analysis [46], other recent studies have shown that the chances of a live birth after euploid embryo transfers were significantly reduced in overweight women, especially in those with a BMI in the obese range (BMI �30) [47]. Supporting these data, a product of conception (POC) analysis showed the overpresentation of euploidy in obese patients compared with lean patients [48], indicating that endometrial changes associated with obesity, such as endometrial morphology, steroid receptors or leukocyte populations, may have a detrimental effect on endometrial receptivity [37].…”

Section: Discussionmentioning

confidence: 85%

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Boynukalın¹,

Gültomruk²,

Cavkaytar³

et al. 2020

PLoS ONE

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Background To assess the predictive value of patient characteristics, controlled ovarian stimulation and embryological parameters on the live birth outcome of single euploid frozen-warmed blastocyst transfer (FBT). Methods This was a retrospective cohort study including 707 single FBTs after preimplantation genetic testing for aneuploidy (PGT-A) that were performed from October 1, 2015, to January 1, 2018. The effects of patient-, cycle-and embryology-related parameters on the live birth outcome after FBT were assessed.

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Section: Discussionmentioning

confidence: 85%

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Boynukalın¹,

Gültomruk²,

Cavkaytar³

et al. 2020

PLoS ONE

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“…17 Although obesity has also been linked to increased miscarriage rates, obesity has not been correlated with embryo aneuploidy. [18][19][20][21] More than the storage of triglycerides, adipose tissue is an endocrine organ generating cytokines and free fatty acids (FFAs)-mostly in the form of palmitic acid, a long-chain saturated fatty acid. The inflamed adipose tissue induces a systemic chronic inflammatory response, which makes other tissue susceptible to conditions such as insulin resistance, hypertension, and cardiovascular disease.…”

Section: Inflammation and Normal Ovarian Physiologymentioning

confidence: 99%

Inflammation and Human Ovarian Follicular Dynamics

2015

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Inflammation is a biologic process that mediates tissue effects including vasodilation, hyperemia, edema, collagenolysis and cell proliferation through complex immunologic pathways. In regards to the ovary, inflammation has key physiologic roles in ovarian folliculogenesis and ovulation. On the other hand inflammatory processes are subject to underlying pathology and if pushed, proinflammatory conditions may have a negative impact on ovarian follicular dynamics. Obesity and polycystic ovary syndrome (PCOS) serve as examples of conditions associated with chronic endogenous production of low-grade pro-inflammatory cytokines. Both conditions negatively impact ovarian folliculogenesis and ovulation. The pages that follow summarize the role of inflammation in normal ovarian follicular dynamics and evidence for its role in mediating the negative effects of obesity and PCOS on ovarian follicular dynamics. The review concludes with a summary supporting a role for lifestyle factors that favorably impact inflammatory process involved in obesity and PCOS to improve ovarian function.

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“…Так, по данным K. Goldman и соавт. [13], не было выявлено разницы в доле анеуплоидных эмбрионов у пациенток с различным ИМТ. По данным B. Kroon и соавт.…”

Section: Discussionunclassified

“…Другим возможным фактором, оказывающим влияние на развитие анеуплоидии эмбрионов, является возраст пациенток. Данные ряда исследований [13] указывают на то, что ожирение не является самостоятельным фактором риска анеуплоидии плода. ИМТ увеличивается с возрастом, что приводит к развитию анеуплоидии [20].…”

Section: Discussionunclassified

Embryo aneuploidy rate and IVF outcomes in patients with overweight and obesity

Долгушина¹,

Desyatkova²,

Korotchenko³

et al. 2017

Probl. reprod.

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Заболеваемость ожирением растет с каждым годом, в том числе у женщин репродуктивного возраста [1]. Известно, что женщины с избыточной массой тела (индекс массы тела-ИМТ≥25 кг/м 2) и ожирением (ИМТ ≥30 кг/м 2) чаще страдают бесплодием и имеют меньше шансов наступления беременности после программ вспомогательных репродуктивных технологий (ВРТ) по сравнению с женщинами с ИМТ <25 кг/м 2 [2-9]. Одной из возможных причин репродуктивных неудач у пациенток с избыточной массой тела и ожирением могут быть хромосомные нарушения у эмбрионов. В нескольких исследованиях были представлены данные о том, что у пациенток с ИМТ ≥25 кг/м 2 статистически значимо увеличивается риск анеуплоидии эмбрионов [10, 11]. Одновременно в литературе представлены данные об отсутствии влияния ожирения на развитие анеуплоидии у потомства [12, 13].

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Association of body mass index with embryonic aneuploidy

Cited by 61 publications

References 33 publications

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer

Inflammation and Human Ovarian Follicular Dynamics

Embryo aneuploidy rate and IVF outcomes in patients with overweight and obesity

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