Association of Body mass index and serum ferritin level in pediatrics with Beta-thalassemia major disease

Yousefian, Saeed; Aliabad, Ghassem Miri; Saleh, Rana; Khedmati, Majid

doi:10.18502/ijpho.v12i1.8359

Cited by 3 publications

(5 citation statements)

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“…Moreover, there was no significant relationship between gender and BMI in the study ( P value < 0.89 ), along with ours ( P value < 0.177 ). 12 Participants were considered underweight according to The Growth Charts for Saudi Children and Adolescents endorsed by The Health Services Council of Saudi Arabia, where a BMI less than −2 standard deviations was identified as underweight.…”

Section: Discussionmentioning

confidence: 99%

“…Journal of Blood Medicine 2022:13 770 among beta thalassemia major patients, as has been reported by several studies. [11][12][13] Chelation therapy has a major role in decreasing or delaying such complications. The findings of this study might help improve the quality of healthcare services provided to these patients by exploring barriers that hinder compliance with chelating therapy.…”

Section: Dovepressmentioning

confidence: 99%

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Endocrine Complications and the Effect of Compliance with Chelation Therapy in Patients with Beta Thalassemia Major in Eastern Province of Saudi Arabia

Habbash¹,

Al-Bati²,

Al-Hashim³

et al. 2022

JBM

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Background Endocrinopathies and metabolic complications are common in beta thalassemia major patients receiving blood transfusions. Chelation therapy has a role in preventing or delaying such complications. However, patients may face difficulties adhering to chelation therapy for several reasons. Aim To evaluate endocrine complications in beta thalassemia major patients (2–30 years) in the Eastern Province of Saudi Arabia and compare the onset of endocrine complications among compliant and noncompliant patients. Moreover, we assessed the barriers that hinder compliance with chelating therapy. Methods A cross-sectional study was conducted on 89 patients (43 males and 46 females) aged 2 to 30 years attending different hospitals in the Eastern Province of Saudi Arabia. A semi-structured questionnaire was used to collect demographic data and medical histories. The questionnaires were completed by face-to-face interviews with the patients or their caregivers, and the required laboratory data were retrieved from the medical records of patients. Results The most prevalent abnormality was underweight detected in (40.9%) of patients, followed by subclinical hypothyroidism (37.7%), short stature (35.2%), hypothyroidism in (17.0%) and diabetes mellitus in (13.6%). A significant difference between those who were compliant with iron chelation therapy and those who were not in terms of the prevalence of short stature ( P value= 0.05 ) and hypothyroidism ( P value= 0.05 ). The percentage of patients who were not compliant with chelation therapy was 21.6% and 9.1% of patients were not taking them at all. Conclusion Despite the role of chelation therapy in the management of iron overload, the risk of secondary endocrine and metabolic complications remained considerable. Subclinical hypothyroidism and short stature were the most frequent endocrine complications encountered in this study.

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Section: Discussionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 99%

Endocrine Complications and the Effect of Compliance with Chelation Therapy in Patients with Beta Thalassemia Major in Eastern Province of Saudi Arabia

Habbash¹,

Al-Bati²,

Al-Hashim³

et al. 2022

JBM

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“…This is in line with Yousefian et al's study which examined 740 patients with major-beta thalassemia, where the BMI rate was reported to be lower when compared to controls. [10] Patients with thalassemia are at risk for nutritional deficiencies due to increased nutritional requirements to maintain normal erythropoiesis and/or lack of intake and absorption of nutrients. [11,12] In patients with delayed sexual development or hypogonadism, there may be a development that is not age-appropriate.…”

Section: Correlation Of Leptin Levels With Free Testosterone and Body...mentioning

confidence: 99%

“…However, the mechanism is still unclear. [10] In a study conducted by Ozata et al, it was found that leptin levels were negatively and significantly correlated with testosterone levels in patients with idiopathic hypogonadotropic hypogonadism both before and after therapy.…”

Section: Introductionmentioning

confidence: 96%

Correlation between Leptin and Free Testosterone Levels in Transfusion-Dependent Thalassemia Male Patients

Lubis

Arto

Syahrini

2023

JETROMI

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Background: Male hypogonadism is a clinical disorder of low testosterone and spermatozoa due to impaired production that can occur at one or more levels in the hypothalamic-pituitary-gonadal (HPG) axis. Apart from iron accumulation, hypogonadism can also occur due to other mechanisms in thalassemia patients, such as the influence of adipose tissue and leptin. The study aimed to assess the relationship between leptin with free testosterone levels and BMI in transfusion-dependent thalassemia. Method: The research design chosen was analytic cross-sectional. The study was conducted at the adult thalassemia polyclinic of Cipto Mangunkusumo General Hospital and Fatmawati General Hospital, during the period July - December 2022. The samples used were male transfusion-dependent thalassemia patients aged over 18 years who were under control at the Thalassemia Polyclinic during the study period. The diagnosis of Thalassemia had been previously established by high-performance liquid chromatography (HPLC) or microcapillary examination. Result: Most patients were major ß thalassemia (87.8%), while HbE ß thalassemia was only 12.1%. Age distribution was with a median of 23 years (minimum-maximum 18-42 years). The clinical symptoms of hypogonadism were erectile dysfunction and decreased libido (12.1% and 9%, respectively). From body mass index examination were underweight 18 (54,5%), normal weight 13 (39,5%), overweight 1 (3%), and obese 1 (3%). Of the 33 transfusion-dependent thalassemia patients, 95% did not reach puberty according to their age (Tanner stage V). Conclusion: There is an association significantly between leptin levels with free testosterone and body mass index in transfusion-dependent thalassemia men.

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“…( 5) Iron overload may result in patients' impaired growth, including inadequate body mass index (BMI) and short stature. (6) Iron accumulation in the pituitary causes hypogonadism and is one of the most frequent complications experienced by TDT patients. It is known that 70-80% of TDT patients who experience hypogonadism may have pubertal failure, sexual dysfunction, and infertility.…”

Section: Bmi Measurementmentioning

confidence: 99%

Testicular Volumes Measurement Comparison by Ultrasound and Orchidometer and Its Relationship with Nutritional Status in Transfusion-dependent Thalassemia

et al. 2023

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BACKGROUND: One type of thalassemia known as transfusion-dependent thalassemia (TDT) requires a lifelong blood transfusion. Iron overload from prolonged blood transfusions causes nutritional disorders and several organs impairment, including the testicles. In contrast to an orchidometer, ultrasound shows more details of the testicles. This study aimed to compare testicular volumes based on ultrasound and orchidometer measurements and correlate testicular volume with nutritional status in TDT patients.METHODS: A cross-sectional study including 27 male thalassemia subjects who underwent routine check-ups was conducted. Measurements of testicular volume using an orchidometer and ultrasound, and body mass index (BMI) was performed. Ultrasound measurement of testicular volume was calculated using the Lambert Formula, while the orchidometer was performed by matching the bead next to the testicle.RESULTS: Most subjects were underweight (63%) or normal weight (37%). However, no significant correlation between BMI and testicular volume was found. As measured using an orchidometer, the mean volume of the right and left testes were 9.22±4.92 mL and 8.67±4.45 mL, respectively. Ultrasound measurement showed the mean values of the right and left testicles were 7.68±3.96 mL and 7.09±4.03 mL, respectively. Testicular measurements obtained using ultrasound showed a significant difference (p<0.05) when compared with the orchidometer. The testicle measured by ultrasound was smaller, which was more accurate. However, the comparison between the right and the left testicular volumes showed no significance.CONCLUSION: Thalassemia patients are mainly underweight, and their nutritional status have no relationship with testicular volume. Ultrasound, as compared to an orchidometer, is better for measuring testicular volume.KEYWORDS: thalassemia, testicle, orchidometer, ultrasound, body mass index

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Association of Body mass index and serum ferritin level in pediatrics with Beta-thalassemia major disease

Cited by 3 publications

References 0 publications

Endocrine Complications and the Effect of Compliance with Chelation Therapy in Patients with Beta Thalassemia Major in Eastern Province of Saudi Arabia

Endocrine Complications and the Effect of Compliance with Chelation Therapy in Patients with Beta Thalassemia Major in Eastern Province of Saudi Arabia

Correlation between Leptin and Free Testosterone Levels in Transfusion-Dependent Thalassemia Male Patients

Testicular Volumes Measurement Comparison by Ultrasound and Orchidometer and Its Relationship with Nutritional Status in Transfusion-dependent Thalassemia

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