Association of body mass index with arterial stiffness and blood pressure components: A twin study

Tárnoki, Ádám Domonkos; Tárnoki, Dávid László; Bogl, Leonie H.; Medda, Emanuela; Fagnani, Corrado; Nisticò, Lorenza; Stazi, Maria Antonietta; Brescianini, Sonia; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Baracchini, Claudio; Meneghetti, Giorgio; Osztovits, Janos; Jermendy, György; Kiss, Róbert Gábor; Préda, István; Karlinger, Kinga; Lannert, Agnes; Molnár, Andrea; Littvay, Levente; Garami, Zsolt; Bérczi, Viktor; Pucci, Giacomo; Baffy, György; Schillaci, Giuseppe; Pietiläinen, Kirsi H.

doi:10.1016/j.atherosclerosis.2013.05.001

Cited by 38 publications

(37 citation statements)

References 44 publications

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“…Variations in SBP and DBP were primarily explained by additive genetic factors, accounting for 61% and 58% of their total variances, with residual variances explained by unique environmental factors, which was consistent with previous studies (Jermendy et al, 2011;Wu et al, 2011). Although low-modest heritability has been estimated in many different ethnic populations (Bochud et al, 2005;DeStefano et al, 2004;Tarnoki et al, 2012), our heritability estimate of PP (0.42) is close to a recent study reported by Tarnoki et al (2013) in Italian, Hungarian, and American twins, reflecting that maybe the heritability of PP does not vary considerably by race. Second, there were significant pair-wise phenotypic correlations among PP, SBP, DBP, and BMI.…”

Section: Discussionsupporting

confidence: 92%

“…The estimate of genetic correlation between SBP and BMI (0.37) was much closer to the results of another Chinese twin study (0.38; Wu et al, 2011). The genetic correlations between BMI with DBP (0.37, 95% CI: 0.28-0.46) were higher than those reported by an early bivariate analysis in Western twins (0.15, 95% CI: 0.03-0.28; Tarnoki et al, 2013). Whether the difference reflects an ethnic disparity or is only due to the differences in methodology of BP and BMI measurements requires further replication studies.…”

Section: Discussionsupporting

confidence: 77%

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Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Zhang

Pang

et al. 2014

Twin Res Hum Genet

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Systolic and diastolic blood pressure, pulse pressure (PP), and body mass index (BMI) are heritable traits in human metabolic health but their common genetic and environmental backgrounds are not well investigated. The aim of this article was to explore the phenotypic and genetic associations among PP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. The studied sample contained 615 twin pairs (17-84 years) collected in the Qingdao municipality. Univariate and multivariate structural equation models were fitted for assessing the genetic and environmental contributions. The AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for each four phenotypes. Heritability estimated in univariate analysis ranged from 0.42 to 0.74 with the highest for BMI (95% CI 0.70-0.78), and the lowest for PP (95% CI 0.34-0.49). The multivariate model estimated (1) high genetic correlations for DBP with SBP (0.87), PP with SBP (0.75); (2) low-moderate genetic correlations between PP and DBP (0.32), each BP component and BMI (0.24-0.37); (3) moderate unique environmental correlation for PP with SBP (0.68) and SBP with DBP (0.63); (4) there was no significant unique environmental correlation between PP and BMI. Overall, our multivariate analyses revealed common genetic and environmental backgrounds for PP, BP, and BMI in Chinese twins.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 77%

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Zhang

Pang

et al. 2014

Twin Res Hum Genet

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“…Az összes egypetéjű iker eredményeit vizsgálva, a genetikai faktorokra kontrollálva, az ikrek közötti BMI-különbség szignifi káns korrelációt mutatott a brachialis szisztolés vérnyomás (SBP), a diasztolés vérnyomás (DBP), a kö-zépartériás nyomás, illetve az aorticus SBP közötti kü-lönbséggel, vagyis a BMI és ezen fenotípusok kapcsolatát döntően a módosítható környezeti faktorok alakítják. Ugyanezen változók tekintetében a BMI-diszkordáns egypetéjű ikerpárok súlyosabb ikertestvére szignifi kán-san magasabb értékeket mutatott, mint a soványabb iker [46].…”

Section: Testösszetétel-vizsgálatokunclassified

Hungarian twin studies: results of four decades

Tárnoki

Horváth

et al. 2013

Orvosi Hetilap

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Az ikervizsgálatok szerepet játszanak a fenotípusos változók kialakulásáért felelős genetikai és környezeti tényezők arányának, továbbá a genotípusok közötti genetikai kapcsoltság vizsgálatában. Magyarországon az ikerkutatások dön-tően az 1970-es években kezdődtek és alapjukat három ikernyilvántartás (köztük két iker-regiszter) biztosította. A vizsgálatok elsősorban a különböző veleszületett rendellenességekre, a fogamzásgátló tabletták és a folsav ikergyakoriságra való hatására, az ikrek pszichoszexuális viselkedésének megismerésére, az alkoholfogyasztási szokások örökletességének becslésére irányultak. Először mutatták ki a laktóz(mal)abszorpció monogénes mendeli öröklődé-sét. 2007-ben alakult meg a Magyar Ikerregiszter, amelynek segítségével több ikervizsgálatra nyílt ismét lehetőség, például a metabolikus szindróma és az érelmeszesedés hátterének megértésére. Nemzetközi ikervizsgálat során többek között az artériás stiffness, a centrális vérnyomás, a carotis intima/media falvastagság, a vénás biomechanika, a testösszetétel, a légzésfunkció és a dohányzási szokások vizsgálatára is sor került. Először sikerült kimutatni a nem alkoholos zsírmáj örökletességének hiányát és a carotisplakkok kialakulásában az öröklődés szerepét. A dolgozat a Magyar Ikerregiszter jövőbeni terveiről is áttekintést nyújt. Orv. Hetil., 2013, 154, 1579-1586. Kulcsszavak: ikerregiszter, öröklődés, környezet, epigenetika, ikerterhesség Hungarian twin studies: results of four decadesTwin studies play a role in examining the contribution of genetic variations and environmental factors responsible for the determination of phenotypic variables and of genetic linkage between genotypes. Hungarian twin studies, supported by three twin registries (among them two twin-database), date back to 1970s. Studies mainly focused on various congenital abnormalities, the effect of contraceptive pills and folic acid on the frequency of twin pregnancies, as well as psychosexual and alcohol consumptional behaviors. Monogenic Mendelian inheritance of lactose (mal) absorption was demonstrated for the fi rst time. Hungarian Twin Registry was founded in 2007, which contributed to the current understanding on the background of several disorders, e.g. metabolic syndrome and atherosclerosis. As part of an international twin study, among others, arterial stiffness, central blood pressure, carotid intima/media thickness, venous biomechanics, body composition, lung function and smoking characteristics were also assessed. Absence of genetic background in non-alcoholic fatty liver disease and high inheritance of carotid plaque characteristics were demonstrated for the fi rst time. The review also aims to summarize future plans of the Hungarian Twin Registry.

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“…In our previous work, we investigated the genetic relationship of novel hemodynamic parameters with lung function, exhaled nitric oxide and body mass index which explored phenotypic and genotypic links between the investigated phenotypes (40,41,42). Therefore, literature still lacks a scientific explanation between novel cardiovascular and ophthalmologic parameters.…”

mentioning

confidence: 99%

Genetic effects on refraction and correlation with hemodynamic variables: A twin study

Toth¹,

Tárnoki²,

Tárnoki³

et al. 2014

Acta Physiologica Hungarica

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Spherical equivalent (SE) has not been linked to increased cardiovascular morbidity. Methods: 132 Hungarian twins (age 43.3±16.9 years) underwent refraction measurements (Huvitz MRK-3100 Premium AutoRefractokeratometer) and oscillometry (TensioMed Arteriograph). Results: Heritability analysis indicated major role for genetic components in the presence of right and left SE (82.7%, 95%CI, 62.9 to 93.7%, and 89.3%, 95%CI, 72.8 to 96.6%), while unshared environmental effects accounted for 17% (95%CI, 6.3% to 37%), and 11% (95%CI, 3.4% to 26.7%) of variations adjusted for age and sex. Bilateral SE showed weak age-dependent correlations with augmentation index (AIx), aortic pulse wave velocity (r ranging between 0.218 and 0.389, all p < 0.01), aortic systolic blood pressure and pulse pressure (r between 0.188 and 0.289, p < 0.05). Conclusions: These findings support heritability of spherical equivalent, which does not coexist with altered hemodynamics (e.g. accelerated arterial aging). Accordingly, SE and the investigated hemodynamic parameters seem neither phenotypically nor genetically associated.Keywords: arterial stiffness, augmentation index, genetics, heritability, refractionThe first "twin study" was published in 1922 by Walter Jablonski, the first ophthalmologist who used both monozygotic and dizygotic twins to examine the factors that determine the development of the refraction of the eye. He declared "the smaller differences are seen in the majority of monozygotic cases, while larger differences occur in dizygotic cases" (23).Since then, numerous articles discussed the role of inheritance, the genetic predisposition and the gene-environment interactions taking part in the formation of the refractive characteristics of the eye confirming that genetic factors account for 77-94% of the genetic variance (10,25,26,43). However, a similar study in a wide-age range sample is still needed. In addition, despite heritability of refraction was thoroughly investigated in the studies *These authors contributed equally to this work.

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Association of body mass index with arterial stiffness and blood pressure components: A twin study

Cited by 38 publications

References 44 publications

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Hungarian twin studies: results of four decades

Genetic effects on refraction and correlation with hemodynamic variables: A twin study

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