Association of body mass index with risk of cognitive impairment and dementia: A systematic review and meta-analysis of prospective studies

Qu, Yi; Hu, He‐Ying; Ou, Ya‐Nan; Shen, Xue‐Ning; Xu, Wei; Wang, Zuo-Teng; Dong, Qiang; Tan, Lan; Yu, Jin‐Tai

doi:10.1016/j.neubiorev.2020.05.012

Cited by 113 publications

(85 citation statements)

References 77 publications

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“…In younger and middle aged adults, overweight and obesity are associated with cognitive impairment, while in old aged people, higher BMIs are associated with better cognition (5-7, 26, 27). A recent meta-analysis showed that in mid-aged people, obesity conferred 1.31-fold excess risk for cognitive impairment, while in old aged people, overweight and obesity conferred a 21 and 25% reduced risk, respectively (5). In our study, there was no significant correlation between obesity and cognition.…”

Section: Discussioncontrasting

confidence: 67%

“…In our study, there was no significant correlation between obesity and cognition. This may be because the participants in our study were only divided into normal weight and overweight, while previous studies have shown that in midlife, underweight also increases the risk of cognitive impairment as overweight (5), and these participants were classified into normal weight, which may affect our results. In old aged people, a previous Chinese study showed that abdominal obesity might increase the risk of cognitive impairment (28).…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies and some meta-analyses have demonstrated that being overweight and obese are harmful to cognition (5)(6)(7)(8)(9)(10), while some studies showed that being overweight maybe helpful to cognition (11,12). Deckers et al found that the association between being overweight and the rate of cognitive decline was definitely affected by age (13).…”

Section: Introductionmentioning

confidence: 99%

“…Deckers et al found that the association between being overweight and the rate of cognitive decline was definitely affected by age (13). Some meta-analysis showed that being overweight was positively associated with dementia in middle-aged people, but negatively associated with cognitive impairment in middle-and old-aged people (5). However, another meta-analysis showed that weight loss in overweight subjects will improve cognition (14), which would indirectly reflect the association between being overweight and cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults

Wang

Zhao

2020

Front. Neurol.

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Purpose: To determine the association between overweight and high-sensitivity C-reactive protein (hs-CRP) with the odds of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.Materials and methods: We conducted a cross-sectional analysis of the follow-up data of 2012 from the APAC study. The Chinese version of the MMSE was used as a cognitive screener, and an MMSE score <24 is generally accepted as indicating cognitive impairment. Multivariable logistic regression was used to estimate the interactions of hs-CRP levels with body mass index (BMI) on the effects of cognitive impairment and its subtypes.Results: Three thousand eight hundred seventy-five participants aged 40–90 years (median age 51.64 y) were enrolled in this study, and 1,788 (46.1%) were overweight. Before and after adjusting for confounders, such as age, sex, BMI, education, current smoking, drinking, physical activity, hypertension, hyperlipidemia, diabetes, and hs-CRP, elevated hs-CRP levels were associated with cognitive impairment in normal-weight participants (crude OR: 2.08, 95%CI: 1.28–3.37, p = 0.003; adjusted OR: 2.06, 95%CI: 1.03–4.10, p = 0.04), but not in overweight participants. There was no statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-item.Conclusion: Elevated hs-CRP levels increase the odds of cognitive impairment in normal-weight participants, but not in overweight participants.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults

Wang

Zhao

2020

Front. Neurol.

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“…In several studies, anthropometric measures such as BMI and WC have been used as predictors of risks of other diseases 37,38 . Despite the purpose of this study was to analyze the correlation between anthropometric factors and anosmia, but failure to prove the relationship between BMI and WC is another limitation.…”

Section: Discussionmentioning

confidence: 99%

A nationwide population-based study in South Korea on a relationship between height and anosmia

Kang

Lee

Han³

et al. 2021

Sci Rep

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The relationship between anosmia and anthropometric factor has not been investigated sufficiently yet. Thus, the purpose of this study was to evaluate anthropometric risk factors of anosmia in an Asian population. Claims data of subjects over 20 years old who underwent a national health examination conducted by the Korean National Insurance Program between 2005 and 2008 were analyzed. They were followed up through the Korean National Insurance Service database. Individuals newly diagnosed with anosmia were identified after the initial health examination until the last follow-up date (December 31, 2016). The incidence of anosmia was high in females younger than 70 years old. The hazard ratio of anosmia was found to be higher in taller groups. The tallest quintile had higher risk than the shortest quintile (hazard ratio = 1.185, 95% confidence interval: 1.147–1.225) after adjusting for age, sex, BMI, income, smoking status, alcohol consumption, regular physical activity, hypertension, diabetes mellitus, and dyslipidemia. This study showed that the incidence of anosmia had a positive association with height. However, careful interpretation is needed to generalize our result because of the limitation of the study population. Further studies are needed to clarify the genetic or environmental causes of anosmia.

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Cognitive behavioural therapy for adults with overweight or obesity

Cai

Tang

et al. 2023

Cochrane Database of Systematic Reviews

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Association of body mass index with risk of cognitive impairment and dementia: A systematic review and meta-analysis of prospective studies

Cited by 113 publications

References 77 publications

Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults

Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults

A nationwide population-based study in South Korea on a relationship between height and anosmia

Cognitive behavioural therapy for adults with overweight or obesity

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