Association of Body Mass Index with Cardiovascular Disease Biomarkers

Loprinzi, Paul D.; Crespo, Carlos; Andersen, Ross E.; Smit, Ellen

doi:10.1016/j.amepre.2014.08.019

Cited by 21 publications

(15 citation statements)

References 12 publications

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“…A study conducted in undernourished participants found an association between CRP and undernutrition [23], which is also in accordance with our nding. Another study found that plasma CRP level was lower in undernourished participants [24], which is consistent with our nding. Moreover, CRP level was positively correlated with BMI in our analysis which is also supported by another study [25].…”

Section: Discussionsupporting

confidence: 93%

“…Among the participants nearly one-third was male. The median (IQR) ages of the healthy and undernourished participants were 24 (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) 5% undernourished participants were smokers and smoking status signi cantly (p < 0.05) differ between these two study groups. Almost similar numbers of healthy and undernourished participants were addicted with different types of substances such as betel leaf, areca nut, slaked lime.…”

Section: Resultsmentioning

confidence: 99%

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Association of Plasma Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) with Undernutrition: A Case-Control Study in Bangladeshi Adults

Hasan

Fahim

Das

et al. 2020

Preprint

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Background: Studies revealed that LRP1 plays pivotal role in adipogenesis, whereas silencing of LRP1 expression can cause inhibition of adipogenesis in animal model and contribute to reduced body size. Therefore a reduction in the level of adipocytic LRP1 might have a role on weight loss. But there is no study that has explored the role of LRP1 on weight loss of human adults. However, it is not feasible to examine the role of adipocytic LRP1 on weight loss due to invasive collection procedure of adipose tissue. But plasma LRP1 can fill that void as it is a biomarker of adipocytic LRP1. Therefore, the aim of this study was to investigate the relationship of plasma low-density lipoprotein receptor-related protein-1 (LRP1) with undernutrition.Methods: A total of 270 Bangladeshi slum-dwelling adults (135 cases, BMI < 18.5 kg/m2 and 135 controls, BMI 18.5-24.9 kg/m2) were enrolled. Their socio-economic, demographic, anthropometric and biomedical data were collected. Plasma LRP1, C-reactive protein (CRP), alpha-1 acid glycoprotein (AGP), and ferritin levels were measured by ELISA, hemoglobin by Hemocue and zinc by atomic absorption spectrometry.Results: The median (IQR) values of plasma LRP1, CRP, AGP, Hemoglobin, zinc and ferritin were 1673.1 (1382.5- 1886.2) ng/ml, 2.1 (0.9 – 4.4) mg/L, 75.8 (62.9 – 95.9) mg/dL, 13.2 (12 – 14.3) g/dL, 0.74 (0.7 – 0.8) mg/L, 59.9 (26.4 – 123.2) ng/mL in healthy participants and 707.7 (588.6- 839.9) ng/ml, 0.8 (0.2 – 1.7) mg/L, 64.7 (52.9 – 86.9) mg/dL, 12.4 (11.4 – 13.4) g/dL, 0.71 (0.6 – 0.8) mg/mL, 43.7 (19.9 – 80.2) ng/mL in undernourished participants, respectively. A strong positive correlation (r = 0.70, p <0.05) between LRP1 and body mass index (BMI) was found. Multivariable logistic regression analysis revealed a positive association between low plasma LRP1 (Adj. OR= 0.98, CI = 0.98, 0.99 and p < 0.05) and undernutrition. Conclusions: The study found that increased level of LRP1 is associated with increased BMI, whereas lower level can contribute to low BMI.

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Association of Plasma Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) with Undernutrition: A Case-Control Study in Bangladeshi Adults

Hasan

Fahim

Das

et al. 2020

Preprint

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show abstract

“…Their results indicate that increased BMI is associated with an adverse effect on all major CHD risk factors 3 . Loprinzi et al examine the associations of underweight, overweight and obesity with kinds of CVD risk factors 4 . Their results showed that underweight adults had significantly lower levels of CRP; total cholesterol; total cholesterol to high-density lipoprotein cholesterol ratio; LDL cholesterol; and triglycerides compared to normal-weight individuals 4 .…”

mentioning

confidence: 99%

Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease

Zhao

et al. 2015

Sci Rep

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Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. It is reported that body mass index (BMI) is risk factor for CVD. Genome-wide association studies (GWAS) have recently provided rapid insights into genetics of CVD and its risk factors. However, the specific mechanisms how BMI influences CVD risk are largely unknown. We think that BMI may influences CVD risk by shared genetic pathways. In order to confirm this view, we conducted a pathway analysis of BMI GWAS, which examined approximately 329,091 single nucleotide polymorphisms from 4763 samples. We identified 31 significant KEGG pathways. There is literature evidence supporting the involvement of GnRH signaling, vascular smooth muscle contraction, dilated cardiomyopathy, Gap junction, Wnt signaling, Calcium signaling and Chemokine signaling in CVD. Collectively, our study supports the potential role of the CVD risk pathways in BMI. BMI may influence CVD risk by the shared genetic pathways. We believe that our results may advance our understanding of BMI mechanisms in CVD.

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“…Since oxidative stress could up-regulate leukocyte ROCK2 concentration, it was possible that through ameliorating oxidative stress, moderate aerobic exercise decreased leukocyte ROCK2 concentration. Second, since an increased cholesterol level is always accompanied by increased generation of isoprenoid intermediates, critical substrates for leukocyte ROCK2 concentration increased [24]. Therefore, cholesterol lowering induced by moderate aerobic exercise may have led to reduced leukocyte ROCK2 concentration.…”

Section: Discussionmentioning

confidence: 99%

Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia

Bai

Sun

et al. 2017

aoms

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IntroductionDyslipidemia is associated with increased rho-associated kinase 2 (ROCK2) concentration. Whether moderate aerobic exercise could attenuate leukocyte ROCK2 concentration is unknown.Material and methodsOne hundred subjects with dyslipidemia and without statin treatment were enrolled and assigned to exercise and control groups. In the exercise group, at least 30 min of moderate aerobic exercise per day 5 times weekly was recommended. In the control group, participants were recommended to undertake exercise of the same intensity as the exercise group but not mandatorily. At baseline and 3 months later, between-group differences were compared.ResultsAt baseline, dyslipidemia in both groups was characterized by increased serum levels of total cholesterol and low density lipoprotein cholesterol (LDL-C). Serum high-sensitivity C-reactive protein (hs-CRP) level was comparably increased too, and the average daily exercise time was extremely low: 5.8 ±2.7 min and 6.2 ±3.1 min respectively. Leukocyte ROCK2 concentration in the two groups was 38.4 ±7.5 mg/ml and 40.2 ±8.2 mg/ml respectively. Three months later, compared with the control group, average daily exercise time was significantly longer in the exercise group (37.4 ±4.3 min vs. 16.5 ±7.5 min, p < 0.05). Leukocyte ROCK2 concentration was also significantly reduced (27.6 ±4.3 mg/ml vs. 34.6 ±5.2 mg/ml, p < 0.05). Serum nitric oxide (NO) concentration in the exercise group was significantly higher than the control group (p < 0.05). Multivariate linear regression analysis revealed that NO and exercise time were significantly associated with leukocyte ROCK2 concentration after adjusting for traditional risk factors.ConclusionsModerate aerobic exercise could effectively attenuate leukocyte ROCK2 concentration in subjects with dyslipidemia.

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Association of Body Mass Index with Cardiovascular Disease Biomarkers

Cited by 21 publications

References 12 publications

Association of Plasma Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) with Undernutrition: A Case-Control Study in Bangladeshi Adults

Association of Plasma Low-Density Lipoprotein Receptor-Related Protein-1 (LRP1) with Undernutrition: A Case-Control Study in Bangladeshi Adults

Pathway analysis of body mass index genome-wide association study highlights risk pathways in cardiovascular disease

Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia

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