Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults

Antony, Benny; Venn, Alison; Cicuttini, Flavia Maria; March, Lyn; Blizzard, Leigh; Dwyer, Terence; Cross, Marita; Jones, Graeme; Ding, Changhai

doi:10.1002/acr.22715

Cited by 16 publications

(21 citation statements)

References 38 publications

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“…Interestingly, compared to those studies on older populations 26e31 , those studying younger population found no association between weight/BMI and cartilage volume 25,32,33 . This may reflect the effects of ageing making knee joints more susceptible to body weight 38 .…”

Section: Discussioncontrasting

confidence: 58%

The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study

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Tian

et al. 2017

Osteoarthritis and Cartilage

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Section: Discussioncontrasting

confidence: 58%

The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study

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Blizzard

Tian

et al. 2017

Osteoarthritis and Cartilage

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“…Similarly, we did not find any significant association between overweight status in childhood and adulthood knee structures, including cartilage volume after 25 years (data not published). However, we found that lean mass in young adults was positively and fat mass was negatively associated with tibial cartilage volume in young Australian adults [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Do early life factors affect the development of knee osteoarthritis in later life: a narrative review

et al. 2016

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Osteoarthritis (OA) mainly affects older populations; however, it is possible that early life factors contribute to the development of OA in later life. The aim of this review is to describe the association between childhood or early adulthood risk factors and knee pain, structural imaging markers and development of knee OA in later life. A narrative overview of the literature synthesising the findings of literature retrieved from searches of computerised databases and manual searches was conducted. We found that only a few studies have explored the long-term effect of childhood or early adulthood risk factors on the markers of joint health that predispose people to OA or joint symptoms. High body mass index (BMI) and/or overweight status from childhood to adulthood were independently related to knee pain and OA in later life. The findings regarding the association between strenuous physical activity and knee structures in young adults are still conflicting. However, a favourable effect of moderate physical activity and fitness on knee structures is reported. Childhood physical activity and performance measures had independent beneficial effects on knee structures including knee cartilage in children and young adults. Anterior knee pain syndrome in adolescence could lead to the development of patellofemoral knee OA in the late 40s. Furthermore, weak evidence suggests that childhood malalignment, socioeconomic status and physical abuse are associated with OA in later life. The available evidence suggests that early life intervention may prevent OA in later life.

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“…32 There is also evidence suggesting fat-free body mass and muscle mass or muscle strength, but not BMI, is positiviely associated with cartilage thickness, while the opposite might be true for fat mass. 29,30,33,34…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid–Binding Protein 4 (FABP4) Is Associated with Cartilage Thickness in End-Stage Knee Osteoarthritis

et al. 2021

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Background There is no single blood biomarker for the staging of knee osteoarthritis (KOA). The purpose of this study was to assess the relationship of obesity, serum biomarkers, the hip-knee-ankle angle (HKAA) with sonographic cartilage thickness. Methods We conducted a cross-sectional study of n = 33 patients undergoing knee arthroplasty. Body mass index (BMI) was recorded, and patients were grouped based on BMI. Serum blood samples were collected, and the following biomarkers were measured using the ELISA technique (subgroup of n = 23): oxidized low-density lipoprotein (oxLDL), soluble receptor for advanced glycation end-products (sRAGE), fatty acid–binding protein 4 (FABP4), membrane-bound phospholipase A2 (PLA2G2A). The HKAA was analyzed on full-length limb standing x-ray images. Cartilage thickness was assessed on ultrasound images. Multivariable regression analysis was performed to account for confounding. Results After adjusting for age, gender, and HKAA, obese patients had thicker medial femoral cartilage (β = 0.165, P = 0.041). Furthermore, lateral cartilage thickness was negatively correlated with FABP4 level after adjusting for of age, gender, BMI, and HKAA (β = −0.006, P = 0.001). Confirming previous studies, after adjustment, FABP4 level was associated with a higher BMI group (β = 42.99, P < 0.001). None of the other markers (oxLDL, PLA2G2A, and sRAGE) was associated with BMI or cartilage thickness. Discussion Our results indicate that BMI has a weak, positive association with cartilage thickness in end-stage KOA patients. FABP4 levels were negatively associated with cartilage thickness. While our study is limited by a small sample size, these results further highlight the role of FABP4 as promising biomarkers of burden of disease in KOA.

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Association of Body Composition and Hormonal and Inflammatory Factors With Tibial Cartilage Volume and Sex Difference in Cartilage Volume in Young Adults

Cited by 16 publications

References 38 publications

The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study

The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study

Do early life factors affect the development of knee osteoarthritis in later life: a narrative review

Fatty Acid–Binding Protein 4 (FABP4) Is Associated with Cartilage Thickness in End-Stage Knee Osteoarthritis

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