Association of blood manganese, selenium with steatosis, fibrosis in the National Health and Nutrition Examination Survey, 2017-18

Spaur, Maya; Nigra, Anne E.; Sanchez, Tiffany  R.; Navas‐Acien, Ana; Lazo, Mariana; Wu, Hui-Chen

doi:10.1016/j.envres.2022.113647

Cited by 16 publications

(11 citation statements)

References 45 publications

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“…This may be attributed to the larger proportion of Non-Hispanic white individuals within the studied population.These ndings emphasize the importance of paying special attention to the potential liver damage caused by urinary heavy metal exposure in these populations. Previous research has highlighted that Mexican Americans have the highest prevalence of NAFLD 33 , and this nding aligns with the results of Spaur M. et al, who also reported a signi cant positive association between blood manganese levels and NAFLD and liver brosis in Mexican Americans 34 . Interestingly, we discovered a negative correlation between urinary Cd levels and advanced liver brosis speci cally among individuals of Other Hispanic ethnicity.…”

Section: Discussionsupporting

confidence: 88%

“…Previous research has established that individuals with a high BMI are more susceptible to developing NAFLD and advanced liver brosis 35,36 . This notion is supported by the ndings of Spaur M. et al, who observed BMI-speci c differences, where positive associations were observed between blood manganese levels and liver steatosis among participants with a BMI of 30 or higher 34 . In our study, we consistently observed a signi cant impact of urinary heavy metal levels on the development of advanced hepatic brosis across various BMI groups.…”

Section: Discussionmentioning

confidence: 56%

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The association between NAFLD and advanced liver fibrosis with urinary heavy metal based on the NHANES 2013-2018

Cai

Jia

Pan

et al. 2023

Preprint

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Background Chronic liver disease poses an escalating health challenge on a global scale. It has been suggested that prolonged exposure to heavy metals could potentially contribute to the development of non-alcoholic fatty liver disease (NAFLD). Our study aimed to assess the correlation between urinary levels of specific heavy metals, including Ba, Cd, Co, Cs, Hg, Mo, Pb, Sb, Sn, Ti, and Ur, and the occurrence of NAFLD and advanced liver fibrosis within the general population of the United States. Methods In our study, we conducted a thorough analysis using data from the NHANES spanning from 2013 to 2018. To examine the correlation between urinary heavy metal concentration and the prevalence of NAFLD and advanced liver fibrosis, we employed a multivariable analysis that accounted for various factors such as sociodemographic characteristics, lifestyle factors, hypertension, and T2DM. This allowed us to control for potential confounding variables and obtain reliable findings regarding the association between urinary heavy metal concentration and the occurrence of NAFLD and advanced liver fibrosis. Results We employed multiple logistic regression models to examine the data, and the results revealed noteworthy findings. Higher levels of urinary Ba, Cd, Co, Pb, Sb, Sn, Tu, and Ur exhibited a significant positive association with NAFLD. Additionally, as the concentration of Cd, Pb, Sb, and Sn increased in urine, the likelihood of advanced liver fibrosis also significantly increased. These findings underscore the significant positive associations between the levels of specific heavy metals in urine and both NAFLD and advanced liver fibrosis. Conclusion The findings of this study suggest a significant association between elevated urinary Ba, Cd, Co, Pb, Sb, Sn, Tu, Ur concentration and NAFLD while a significant correlation was also found between higher urinary levels of Cd, Pb, Sb, Sn and advanced liver fibrosis.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 56%

The association between NAFLD and advanced liver fibrosis with urinary heavy metal based on the NHANES 2013-2018

Cai

Jia

Pan

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…At present, a major issue on a worldwide scale is Cd pollution. The epidemiological investigation results showed that serum Cd concentration was positively correlated with the development of nonalcoholic fatty liver disease ( NAFLD ) ( Spaur et al, 2022 ). NAFLD is the most common cause of chronic liver disease in more than 25% of the world's population.…”

Section: Introductionmentioning

confidence: 99%

Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-α and reducing oxidative stress

Sun

Bian

et al. 2023

Poultry Science

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“…In contrast, the roles of Se in different types of NAFLD are complex and conflicting ( 198 ). It seems that increased plasma/serum Se levels are positively associated with elevated prevalence of liver steatosis but negatively associated with that of hepatic fibrosis or HCC ( 198 – 201 ). Finally, exposure to toxic heavy metals (such as Pb, Cd, Hg, and Ni) was significantly associated with the onset and progression of NAFLD in different regions of the world, which is probably a causative factor of hepatic steatosis and fibrosis in some patients ( 202 – 208 ).…”

Section: Recent Progress In Ionomics Of Metabolic Diseasesmentioning

confidence: 99%

Recent advances in the application of ionomics in metabolic diseases

et al. 2023

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Trace elements and minerals play a significant role in human health and diseases. In recent years, ionomics has been rapidly and widely applied to explore the distribution, regulation, and crosstalk of different elements in various physiological and pathological processes. On the basis of multi-elemental analytical techniques and bioinformatics methods, it is possible to elucidate the relationship between the metabolism and homeostasis of diverse elements and common diseases. The current review aims to provide an overview of recent advances in the application of ionomics in metabolic disease research. We mainly focuses on the studies about ionomic or multi-elemental profiling of different biological samples for several major types of metabolic diseases, such as diabetes mellitus, obesity, and metabolic syndrome, which reveal distinct and dynamic patterns of ion contents and their potential benefits in the detection and prognosis of these illnesses. Accumulation of copper, selenium, and environmental toxic metals as well as deficiency of zinc and magnesium appear to be the most significant risk factors for the majority of metabolic diseases, suggesting that imbalance of these elements may be involved in the pathogenesis of these diseases. Moreover, each type of metabolic diseases has shown a relatively unique distribution of ions in biofluids and hair/nails from patients, which might serve as potential indicators for the respective disease. Overall, ionomics not only improves our understanding of the association between elemental dyshomeostasis and the development of metabolic disease but also assists in the identification of new potential diagnostic and prognostic markers in translational medicine.

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Association of blood manganese, selenium with steatosis, fibrosis in the National Health and Nutrition Examination Survey, 2017-18

Cited by 16 publications

References 45 publications

The association between NAFLD and advanced liver fibrosis with urinary heavy metal based on the NHANES 2013-2018

The association between NAFLD and advanced liver fibrosis with urinary heavy metal based on the NHANES 2013-2018

Melatonin alleviates cadmium-induced nonalcoholic fatty liver disease in ducks by alleviating autophagic flow arrest via PPAR-α and reducing oxidative stress

Recent advances in the application of ionomics in metabolic diseases

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