Association of birthweight with diabetes and insulin sensitivity or secretion in the Japanese general population

Oya, Junko; Nakagami, Tomoko; Kurita, Moritoshi; Yamamoto, Yayoi; Hasegawa, Yukiko; Tanaka, Yuki; Endo, Yasuhiro; Uchigata, Yasuko

doi:10.1111/jdi.12325

Cited by 10 publications

(9 citation statements)

References 38 publications

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“… 3 Several Japanese studies also reported an inverse association between birth weight and DM. 11 , 12 The reported odds ratio in one study was larger than that observed in the present study (3.52 for birth weight <2500 g compared with 3001–3200 g), but with a wide confidence interval (95% CI, 1.04–11.96). 12 The present study confirmed the association with a larger sample distributed throughout Japan.…”

Section: Discussioncontrasting

confidence: 83%

Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study

Katanoda¹,

Noda

Goto³

et al. 2017

Journal of Epidemiology

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BackgroundAlthough birth weight is considered as a fetal determinant of the development of adult-onset diabetes mellitus (DM), its public health importance relative to adult body mass index (BMI) remains unclear. We aimed to examine the association between adult-onset DM and birth weight in relation to adult BMI.MethodsWe conducted a self-administered questionnaire as a baseline survey of the Japanese Nurses' Health Study cohort between 2001 and 2007. Exclusion criteria were applied to the volunteer sample of 49,927 female nurses (age <30 years or unknown, current pregnancy, development of DM before the age of 30 years, unknown core variables), and data from 26,949 female nurses aged 30 years or older were used. The association between history of DM diagnosis and birth weight was analyzed using logistic regression.ResultsA linear inverse association was observed between birth weight and DM, after adjustment for age, BMI, and parental history of DM. The odds ratio for developing DM per 100 g increase in birth weight was 0.93 (95% confidence interval [CI], 0.90–0.96). The association was unchanged when birth weight was converted to percentile for gestational age. In the BMI-stratified analysis, the odds ratio for DM in the <2500 g birth weight group reached 4.75 (95% CI, 1.22–18.44, compared to the reference 3000–3499 g group) among women with normal low BMI (18.5–20.9).ConclusionsBirth weight and its percentile for gestational age were associated with adult-onset DM. Attention should be paid to the risk of DM among women born with low weight, even when their current BMI is normal.

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Section: Discussioncontrasting

confidence: 83%

Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study

Katanoda¹,

Noda

Goto³

et al. 2017

Journal of Epidemiology

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“…The present findings were consistent with those of previous studies from different populations and ethnic groups 1,2,[15][16][17] . A recent global meta-analysis based on 49 studies showed a J-shaped association between birthweight and type 2 diabetes mellitus 3 , with the lowest risk for type 2 diabetes mellitus reported for birthweights of 3,500-4,000 g. Previously, several studies from Japan had reported an inverse relationship between birthweight and diabetes 4,6,7 . For instance, the Japanese Nurses' Health Study showed a linear inverse relationship between birthweight and adult-onset diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…The previous studies showed that low birthweight (LBW) was a significant risk factor for type 2 diabetes mellitus, but whether high birthweight (HBW) also contributes to the development of type 2 diabetes mellitus is controversial [1][2][3] . Several studies have addressed the association between birthweight and type 2 diabetes mellitus in Japan [4][5][6][7] , none of which were carried out based on an accurate diagnosis of type 2 diabetes mellitus using a 75-g oral glucose tolerance test (75-g OGTT).…”

Section: Introductionmentioning

confidence: 99%

Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study

Yokoyama

Saito

Ueno

et al. 2020

J of Diabetes Invest

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Aims/Introduction Low birthweight is reportedly associated with type 2 diabetes mellitus; however, this association has not been confirmed in the Japanese population, and whether high birthweight is associated with type 2 diabetes mellitus is controversial. We aimed to investigate the association between birthweight and type 2 diabetes mellitus among a general Japanese population. Materials and Methods Overall 1,135 middle‐ to old‐aged Japanese men and women were enrolled in the Toon Health Study. A 75‐g oral glucose tolerance test was used to diagnose type 2 diabetes mellitus, and a questionnaire survey about birthweight was administered. The association between birthweight and the prevalence of type 2 diabetes mellitus in later life of the participants was examined using multivariable logistic regression analysis. Stratified analysis by current body mass index was also carried out. Results The mean age was 56.5 ± 12.2 years. Type 2 diabetes mellitus was observed in 9.3% of the participants in this study. Compared with the reference group (2,500–3,999 g), the adjusted odds ratio of the low‐birthweight group (<2,500 g) for type 2 diabetes mellitus was 2.46 (95% confidence interval 1.48–4.10). The association between the high‐birthweight group (≥4000 g) and type 2 diabetes mellitus was not significant after including family history of diabetes in the multivariable model. The odds ratio of the low‐birthweight group for type 2 diabetes mellitus was higher in the overweight/obese group than in the non‐overweight group. Conclusions Low birthweight was associated with an increased risk of type 2 diabetes mellitus in a Japanese population, especially in overweight/obese individuals.

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“…This result is in line with previous studies in Japanese individuals which showed that birth weight is inversely associated with the risk of diabetes. [5][6][7] These cross-sectional studies conducted in Japanese populations included subjects with diabetes, whereas we studied only nondiabetic subjects. Thus, the findings of our study provide further evidence that low birth weight may be linked to glycemic status, even before the onset of diabetes in adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…In most studies, birth weight was inversely related to the risk of diabetes. [4][5][6][7] However, its public health importance relative to current lifestyle factors for the risk of diabetes is not fully understood. The identification of dominant factors that contribute to the risk of diabetes is important to achieve primary prevention of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Does physical activity attenuate the association between birth weight and glycated hemoglobin in nondiabetic Japanese women?

Aoyama

Miyatake

Seki

et al. 2019

J Dev Orig Health Dis

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AbstractLower birth weight is associated with a risk of type 2 diabetes in adulthood. However, it is not clear whether this association is modified by physical activity. This study aimed to examine the association between birth weight and glycemic status and whether this association is mediated by moderate- and vigorous-intensity activity (MVPA) in Japanese women. The participants were 103 nondiabetic women (47.4 ± 10.8 years), who underwent health checkups in which data of glycated hemoglobin (HbA1c) were collected. Abdominal circumference (AC) was measured at the umbilical region. Birth weight was obtained from the Maternal and Child Health Handbook records or reported based on the participant’s or his/her mother’s recall. Time (min/day) spent in MVPA (≥3.0 metabolic equivalents) was objectively measured using a triaxial accelerometer (Actimarker EW4800). Birth weight was inversely correlated with HbA1c (r = −0.32, P < 0.01). Multiple linear regression analyses revealed that lower birth weight was associated with increased HbA1c (β = −0.22, P < 0.05) even after adjusting for age, state of menstruation, AC, and family history of diabetes. This association was little changed when MVPA was introduced as an independent variable in the model (β = −0.23, P < 0.05). These results suggest that lower birth weight may be associated with higher HbA1c levels before the onset of type 2 diabetes, irrespective of adulthood physical activity. Early-life development should be taken into account when considering the risk of diabetes in Japanese women, even if they are physically active.

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Association of birthweight with diabetes and insulin sensitivity or secretion in the Japanese general population

Cited by 10 publications

References 38 publications

Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study

Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study

Low birthweight is associated with type 2 diabetes mellitus in Japanese adults: The Toon Health Study

Does physical activity attenuate the association between birth weight and glycated hemoglobin in nondiabetic Japanese women?

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