Association of birth weight with osteoporosis and osteoarthritis in adult twins

Antoniades, L

doi:10.1093/rheumatology/keg227

Cited by 102 publications

(98 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reported association between factors in the intrauterine environment and birth weight and the subsequent development of certain adult diseases may also introduce bias (MZ twins, in general, have a lower birth weight than DZ twins). Although it has been shown that birth weight is associated with adult weight, there is no evidence to support the association between birth weight and the development of OA in later life (31). Our twin subjects had no greater prevalence of knee OA than that in the general population (28).…”

Section: Discussioncontrasting

confidence: 64%

The association of body mass index and osteoarthritis of the knee joint: An examination of genetic and environmental influences

Manek

Hart

Spector

et al. 2003

Arthritis & Rheumatism

185

102

View full text Add to dashboard Cite

Objective. To examine the genetic and environmental influences on the known association between body mass index (BMI) and knee osteoarthritis (OA), using adult twin data.Methods. Bilateral knee radiographs were obtained from 785 pairs of healthy female twins (mean age 54.5 ؎ 7.8 years) from the St. Thomas' Hospital Adult Twin Registry (261 monozygotic [MZ] and 524 dizygotic [DZ] twin pairs). Tibiofemoral knee OA was graded according to the Kellgren and Lawrence (K/L) scoring system on an ordinal scale of 0-4. Presence of knee OA was defined as a K/L grade of >2 on either side of the knee joint. Body weight and height were measured and the subjects were stratified into quartiles of BMI. Crosstrait cross-twin association of BMI and knee OA was assessed by logistic regression, to assess whether genetic or environmental influences explain the BMI-knee OA link. The genetic (heritability) and environmental contributions to each of the measures were estimated using path modeling.Results. A strong association was found between high BMI and the presence of knee OA (odds ratio 3.90 for highest versus lowest quartile of BMI; P ‫؍‬ 0.0001). The heritability of knee OA was 50.4% (95% confidence interval [95% CI] 34-62%) and that of BMI was 55.7% (95% CI 35-72%). However, cross-trait cross-twin associations were not significantly different from unity in either the MZ or DZ twin pairs, indicating that shared genetic influences were unlikely to explain the association. Path modeling showed that the model containing additive genetic factors, common environmental factors, and unique environmental factors had the best fit to the data overall. The shared genetic path between BMI and knee OA could be dropped without deterioration in the fit of the model.Conclusion. The strong association between high BMI and knee OA is not likely to be mediated by shared genetic factors. The results imply that environmental modification of BMI can influence knee OA.

show abstract

Section: Discussioncontrasting

confidence: 64%

The association of body mass index and osteoarthritis of the knee joint: An examination of genetic and environmental influences

Manek

Hart

Spector

et al. 2003

Arthritis & Rheumatism

185

102

View full text Add to dashboard Cite

show abstract

“…Coupled with animal studies (13)(14)(15), these data suggest that birth size is controlled at least in part by the intrauterine environment rather than by the genetic inheritance from both parents. Finally, a recent study that examined the association of birth weight with bone mass in a twin study of Ͼ4000 women confirmed that bone mass and especially BMC were highly associated with birth weight in both monozygotic and dizygotic twins (16). These associations point to environmental rather than genetic factors underlying the observed relationships.…”

Section: Discussionmentioning

confidence: 84%

Birth Weight and Weight at 1 Year Are Independent Determinants of Bone Mass in the Seventh Decade: The Hertfordshire Cohort Study

et al. 2005

View full text Add to dashboard Cite

Several studies have shown relationships between growth in early life and adult bone mass; in this article, we evaluate the relative contributions of pre-and postnatal factors to bone mass in the seventh decade. A total of 498 eight men and 468 women who were born in Hertfordshire during the period 1931-1939 and still living there were recruited. Detailed birth records were available. Participants attended a clinic where they completed a detailed health questionnaire, before performance of anthropometric measurements and bone densitometry of the proximal femur and lumbar spine (Hologic QDR 4500). Birth weight was associated with bone mineral content in both men (proximal femur: r ϭ 0.16, p ϭ 0.0003; lumbar spine: r ϭ 0.10, p ϭ 0.03) and women (proximal femur: r ϭ 0.16, p ϭ 0.0008; lumbar spine: r ϭ 0.11, p ϭ 0.03); relationships with bone mineral density were weaker and were significant at the proximal femur in men only (p ϭ 0.03). Relationships between weight at 1 y and bone mineral content were even stronger (proximal femur: men r ϭ 0.22, p Ͻ 0.0001; women r ϭ 0.14, p ϭ 0.002). In men, 18% of the variance in proximal femoral bone area was explained by a model that included birth weight, weight at 1 y, and adult weight, with the relative contributions attributed to each being 2.8, 6.8, and 8.2%, respectively. In women, similar modeling produced figures of 6.7, 4.2, and 3.9% (overall variance of 15% in proximal femoral bone area). Hence, weight at each of these three points in the life course is important in the determination of adult bone mass, with greater contributions of earlier growth to bone size and mineral content than to bone mineral density. Abbreviations BMAD, bone mineral apparent density BMC, bone mineral content BMD, bone mineral density BMI, body mass index DEXA, dual-energy x-ray absorptiometry HRT, hormone replacement therapy Several epidemiologic studies from around the world have shown relationships between growth in early life and adult bone mass. Initial work in Bath (1) and Hertfordshire, UK (2), showed relationships between weight at 1 y and adult bone mineral content (BMC), but more recent studies (3-5) have also found evidence of an association between birth weight and adult bone mass. Furthermore, a Finnish study (6) demonstrated a direct association between low birth length, poor childhood growth, and later risk for hip fracture. Hence, we sought to evaluate the relative contribution of pre-or postnatal growth to the determination of adult bone mass by using a larger birth cohort of men and women who were born in Hertfordshire in the 1930s and still resident there, for whom extensive childhood records, including birth weight and weight at 1 y, were available. METHODSA total of 768 men and 714 women who were aged 60 -75 y completed this study, based around East Hertfordshire. The selection procedure for these individuals was as follows: in brief, with the help of the National Health Service Central Registry at Southport and Hertfordshire Family Health Service Association, we traced men ...

show abstract

“…2 29 A recent twin study showed that birth weight was related to BMD, independently of maternal factors, but not independently of adult height and weight. 29 An association between family position and bone health does not seem to have been previously reported.…”

Section: Policy Implicationsmentioning

confidence: 85%

Lifecourse study of bone health at age 49–51 years: the Newcastle thousand families cohort study

Pearce

Birrell²,

Francis³

et al. 2005

J Epidemiol Community Health

View full text Add to dashboard Cite

Objective: To quantify the direct and indirect effects of fetal (position in family, weight, and social class at birth), childhood (breast feeding, growth, infections, and social class in childhood, age at menarche), and adult life (social class, alcohol consumption, smoking, diet, reproductive history, exercise, hormone replacement therapy use), and adult size (height, weight) on bone health at age 49-51 years, as measured by bone mineral density, total scanned bone area of the hip and lumbar spine, and femoral neck shaft angle. Design: Follow up study of the Newcastle thousand families birth cohort established in 1947. Participants: 171 men and 218 women who attended for dual energy x ray absorptiometry scanning. Main results: Fetal life explained around 6% of variation in adult bone mineral density for men, but accounted for less than 1% for women. Adult lifestyle, including effects mediated through adult weight accounted for over 10% of variation in density for men and around 6% for women. Almost half of variation in bone area for men was explained by early life. However, most of this was mediated through achieved adult height and weight. In women, less than 5% of variation in bone area was accounted for by early life, after adjusting for adult size. Most of the variation in each of the indicators for both sexes was contributed either directly or indirectly by adult lifestyle and achieved adult height and weight. Conclusions: The effect of fetal life on bone health in adulthood seems to be mediated through achieved adult height.

show abstract

Association of birth weight with osteoporosis and osteoarthritis in adult twins

Cited by 102 publications

References 38 publications

The association of body mass index and osteoarthritis of the knee joint: An examination of genetic and environmental influences

The association of body mass index and osteoarthritis of the knee joint: An examination of genetic and environmental influences

Birth Weight and Weight at 1 Year Are Independent Determinants of Bone Mass in the Seventh Decade: The Hertfordshire Cohort Study

Lifecourse study of bone health at age 49–51 years: the Newcastle thousand families cohort study

Contact Info

Product

Resources

About