Association of biophysical forces with impaired remodeling mechanisms of the abdominal aortic aneurysm wall

Vorp, David A.; Chew, Douglas W.; Sakamoto, Naoya; Sakamoto, Masato; Makaroun, Michael S.

doi:10.1016/s0021-9290(06)84121-7

Cited by 1 publication

(1 citation statement)

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“…Current clinical evaluation of AAA rupture risk is by measurement of the diameter; however, there is increasing evidence that biomechanical factors are associated with growth and rupture and may offer potential as clinical markers of disease. Peak tissue stress has been proposed as an indicator of rupture [5][6][7], and elevated tissue stresses are associated with increased collagen production [1], increased growth rate [8], and an activated immune response and impaired remodelling [9].…”

Section: Introductionmentioning

confidence: 99%

Fluid—structure interaction in axially symmetric models of abdominal aortic aneurysms

Fraser

Lee

et al. 2008

Proc Inst Mech Eng H

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Abdominal aortic aneurysm disease progression is probably influenced by tissue stresses and blood flow conditions and so accurate estimation of these will increase understanding of the disease and may lead to improved clinical practice. In this work the blood flow and tissue stresses in axially symmetric aneurysms are calculated using a complete fluid-structure interaction as a benchmark for calculating the error introduced by simpler calculations: rigid walled for the blood flow, homogeneous pressure for the tissue stress, as well as one-way-coupled interactions. The error in the peak von Mises stress in a homogeneous pressure calculation compared with a fluid-structure interaction calculation was less than 3.5 per cent for aneurysm diameters up to 7 cm. The error in the mean wall shear stress, in a rigid-walled calculation compared with a fluid-structure interaction calculation, varied from 30 per cent to 60 per cent with increasing aneurysm diameter. These results suggest that incorporation of the fluid-structure interaction is unnecessary for purely mechanical modelling, with the aim of evaluating the current rupture probability. However, for more complex biological modelling, perhaps with the aim of predicting the progress of the disease, where accurate estimation of the wall shear stress is essential, some form of fluid-structure interaction is necessary.

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