Association of benign prostatic hyperplasia and subsequent risk of bladder cancer: an Asian population cohort study

Fang, Chu-Wen; Liao, Chien-Chang; Wu, Shih-Chi; Muo, Chih‐Hsin

doi:10.1007/s00345-018-2216-8

Cited by 14 publications

(6 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a close relationship between CKD and bladder cancer [20, 32], and BPH has been reported to be a risk factor for bladder cancer in males [33]. However, in the current study, there was an increased incidence of bladder cancer in CKD patients (HR = 4.46.…”

Section: Discussioncontrasting

confidence: 67%

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

et al. 2019

Self Cite

View full text Add to dashboard Cite

ObjectivesStudies have shown a high risk of tumor development within a bladder diverticulum (BD). We were interested in the relationship between BD and the development of bladder cancer. Herein, we attempted to investigate whether there exists an association between documented BD and subsequent risk of bladder cancer.MethodsWe identified 10,662 hospitalized urology patients, including 2,134 documented BD patients (study cohort) and 8,528 non-BD subjects (comparison cohort) from Taiwan’s National Health Insurance database. Only urology patients were enrolled in the study to minimize selection bias. The two cohorts were frequency-matched 1:4 by age, sex and index-year. Patients with less than one year of follow-up were excluded to avoid inverting cause and effect. Risks of developing bladder cancer were estimated using the Cox proportional hazard regression model.ResultsThere was an increased bladder cancer risk in the documented BD patients. The incidence of bladder cancer in documented BD patients was 2.60-fold higher than that in the comparison group, and the overall risk-factor-adjusted hazard ratio was 2.63 (95% CI, 1.74–3.97). Moreover, stratified analysis by sex also showed that documented BD patients were at higher risk of subsequent bladder cancer than the comparison cohort. The effect of BD on the risk of bladder cancer was higher in males than in females and was more profound in patients without comorbidities than in those with comorbidities.ConclusionIn this population-based longitudinal study, urology patients with documented BD might have an elevated risk of subsequent bladder cancer. Based on the limitations of the retrospective study design, further studies are required.

show abstract

Section: Discussioncontrasting

confidence: 67%

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Fang et al [ 22 ] conducted a cohort study of 35,092 patients including 17,546 BPH patients and 17,546 comparisons from the National Health Insurance database and found an increased lifelong risk of BCa in patients who previously underwent trans-urethral resection of prostate (TURP) (hazard risk, 6.17), considering the treatment as a negative prognostic factor for BCa.…”

Section: Discussionmentioning

confidence: 99%

The association between postvoid residual and response to standard therapy in male and female patients with non–muscle-invasive bladder cancer

Gianfrancesco¹

2023

Curr Urol

View full text Add to dashboard Cite

Background The urinary retention is recognized as a promoting factor for bladder cancer, but its role as prognostic factor of therapeutic response has not yet been widely considered. To correlate bladder outlet characteristics with short-term response to treatment in non–muscle-invasive bladder cancer. Materials and methods We carried out a case-control study on 600 consecutive patients with a first diagnosis of non–muscle-invasive bladder cancer, recruited at the first endoscopic follow-up visit after standard treatment: 200 patients were not tumor-free (cases) and 400 were tumor-free (controls). Patients were compared based on baseline and bladder-outlet characteristics ("functional parameters”: postvoid residual volume [PVR], International Prostatic Symptoms Score, perceived quality of bladder outlet). t Test, χ 2 test, receiver operating characteristic curves, logistic correlations, and multivariate analysis were applied. Results The cases had higher statistically significant PVR values compared with controls. We reported a linear correlation of no–tumor-free status with PVR (R 2 = 0.087, p < 0.005); the receiver operating characteristic curves revealed an area under the curve of 0.824 (95%confidence interval, 0.783–0.865; optimal PVR cutoff, 50 mL). In the multivariate analysis, age, American Society of Anesthesiologists score ≥2, risk category ≥intermediate, and all functional parameters represented independent factors for no–tumor-free status. Conclusions Urinary retention could represent a prognostic factor of treatment response, and its active treatment should be considered as an important therapeutic step into the clinical management of bladder cancer patients.

show abstract

“…Nonetheless, the published evidence showed no consistency in the causality of BPH and BLCA. According to a few studies, BPH may increase the likelihood of developing BLCA ( Fang et al, 2018 ; Lenis et al, 2020 ) and is a crucial risk factor for BLCA, especially for patients with type 2 diabetes ( Tseng, 2013 ). In one meta-analysis that systematically reviewed 16 case-control studies and 10 cohort studies, BPH was associated with a higher incidence of BLCA (18).…”

Section: Discussionmentioning

confidence: 99%

Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study

Wang²,

Zhang³

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Background: Observational studies have suggested a possible association between benign prostate hyperplasia (BPH) and bladder cancer (BLCA). However, these studies are prone to errors and limitations or confounding factors, making them unsuitable for assessing the causal relationship between BPH and BLCA.Objective: Two-sample Mendelian randomization (MR) was performed to determine a possible association between genetically predicted BPH and the risk of BLCA.Methods: A two-sample MR analysis was performed utilizing the Integrative Epidemiology Unit genome-wide association (GWAS) database of the Medical Research Council, United Kingdom A series of control steps, including five primary methods, were performed to identify the most suitable instrumental variables (IVs) for MR analysis. Sensitivity analysis was conducted to avoid statistical errors, including heterogeneity and pleiotropic bias.Results: Genetic variants associated with BPH (P < 5 × 10–8) and BLCA (P < 5 × 10–6) were identified as instrumental variables and assessed using GWAS summary data (BPH, 4,670 cases vs. 458,340 controls; BLCA, 1,279 cases vs. 372,016 controls). BPH exhibited a positive effect on the occurrence of BLCA (inverse variance weighted (IVW), odds ratio (OR) = 1.095, 95% confidence interval (CI) = 1.030–1.165, p = 0.003), but there was no causal effect for BLCA on BPH (IVW, OR = 1.092, 95% CI = 0.814–1.465, p = 0.554).Conclusion: Genetically predicted BPH was associated with a higher risk of BLCA in all histological subtypes. In contrast, the evidence was not significant to back the causality of genetically induced BLCA on BPH. These findings indicate that BPH plays a key role in developing BLCA in the European population. Further studies are needed to uncover the underlying mechanisms.

show abstract

Association of benign prostatic hyperplasia and subsequent risk of bladder cancer: an Asian population cohort study

Abstract: In this study, BPH patients were found to have an increased risk of subsequent bladder cancer. Based on the limitations of retrospective nature, further studies are needed.

Cited by 14 publications

References 43 publications

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients

The association between postvoid residual and response to standard therapy in male and female patients with non–muscle-invasive bladder cancer

Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study

Contact Info

Product

Resources

About