Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis

Algarni, Mohammed; Mirza, Ahmad A.; Althobaiti, Awwadh; Al-Nemari, Hanan H; Bakhsh, Lamees S

doi:10.1007/s00405-018-5146-6

Cited by 57 publications

(37 citation statements)

References 22 publications

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“…According to Gülşah et al, 19 no relationship was found between vitamin D, total calcium levels, BPPV incidence and recurrence. And a meta-analysis 21 by AlGarni et al failed to establish a relationship between the occurrence of BPPV and low vitamin D levels. However, vitamin D supplementation therapy has recently been attracting attention in an effort to reduce the recurrence of BPPV.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Rhim¹

2020

Int Arch Otorhinolaryngol

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Introduction There have been reports indicating that patients with frequently recurring benign paroxysmal positional vertigo (BPPV) had vitamin D deficiency, and some studies indicated that the treatment of severe vitamin D deficiency is effective in the reduction of the recurrence of BPPV. Objective The purpose of the present study was to examine the effects of Vitamin D3 injection on recurrence among patients with a 10 ng/mL or lower 25-hydroxyvitamin D blood concentration diagnosed with BPPV. Methods Among 99 patients with idiopathic BPPV with vitamin D deficiency, 25 patients (case group) were submitted to 3 to 4 injections of 200,000 IU of vitamin D3 in the first year. In total, 50 patients in the control group were selected through frequency matching, with 25 patients in the case group. Age, gender, and type of BPPV are used in matching variables with 1:2 matched data. The subjects of the study group were followed up for 24 months. Results The differences in relapse rates between the case and the control groups were examined using the non-parametric Kruskal-Wallis test for k independent samples. With regard to the relapse rates of the entire case and control groups by period, from 0 to 6 months (p < 0.531), from 7 to 12 months (p < 1.000), and from 13 to 24 months (p < 0.711), and in the entire study period (p < 0.883) there were no statistically significant differences. Conclusion The present case-control study indicated that vitamin D3 injection had no significant effect on the recurrence of BPPV patients with vitamin D deficiency when age, gender, and type of BPPV were homogeneous between the two groups.

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Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Rhim¹

2020

Int Arch Otorhinolaryngol

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“…31,[33][34][35][36][37] Mean serum vitamin D concentrations may differ between institutions in the study country. 8,10,38,39 Therefore, direct comparison of values in the study results requires close attention. These differences in serum levels may be one of the factors for the divergence of research findings regarding the relationship between vitamin D and BPPV.…”

Section: Discussionmentioning

confidence: 99%

Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly

Bazoni

Ciquinato

Marquez

et al. 2019

Int Arch Otorhinolaryngol

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Introduction Studies have found that elderly patients with benign paroxysmal positional vertigo (BPPV) may present low levels of vitamin D (25 (OH) D), changes in bone mineral density, and diabetes mellitus (DM). Objective: To investigate the possible association between BPPV, bone mineral density, hypovitaminosis D, 25 (OH) D and DM. Methods The sample consisted of 109 elderly subjects. The BPPV was verified by a standardized questionnaire and the Dix-Hallpike maneuver. Blood samples were collected for the investigation of 25 (OH) D serum levels. The bone mineral density was evaluated by means of a densitometer. Diabetes mellitus verification was performed using a self-reported questionnaire. Results Of the 109 participants, 17 had BPPV. There was a statistically significant difference between BPPV and gender (p = 0.027, phi = 0.222), with female representing 88.2% of those with BPPV. In the group with BPPV, there was a statistically significant difference for the amount of vitamin D found (p = 0.001) and for age (p = 0.001). In the elderly group with DM and BPPV, a difference was found for the standard deviation of the femur (p = 0.022) with posthoc Dunn, identifying the difference between diabetics with and without BPPV (p = 0.047). Conclusion Although no association was found (25 (OH) D levels) with BPPV in the general population of this study, it was observed that there was an association with bone mineral density in the elderly group with DM and BPPV, and, in the group with BPPV, there was an association between the amount of vitamin D and age.

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“…Disorders of bone mineralisation in the course of osteoporosis probably affect the structure of otoliths. It was confirmed that low levels of vitamin D and disorders of bone mineralisation (which could be due to HT) increase not only the risk of BPPV but also the recurrence of the condition [35][36][37][38].…”

Section: Benign Paroxysmal Positional Vertigomentioning

confidence: 99%

“…Być może zaburzenia mineralizacji tkanki kostnej w przebiegu osteoporozy wpływają na ich budowę strukturalną. Udowodniono, że niskie stężenie witaminy D i zaburzenia mineralizacji tkanki kostnej (za co może być odpowiedzialna choroba Hashimoto) zwiększają nie tylko ryzyko wystąpienia położeniowego zawrotu głowy, ale również częstość nawrotów choroby [35][36][37][38].…”

Section: Introductionunclassified

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Miśkiewicz-Orczyk

Lisowska

Kajdaniuk

et al. 2020

Endokrynologia Polska

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Vertigo and balance disorders are common symptoms reported by approximately 15-20% of the adult population worldwide. For many years thyroid diseases have been suspected as the cause of vertigo by ENT physicians. Almost every patient hospitalised due to severe vertigo is investigated for thyroid disease as a suspected cause of acute vestibulopathy. The issue presented in this paper is related to a difficult and poorly understood relationship between autoimmune thyroid disease and peripheral vertigo. (Endokrynol Pol 2020; 71 (1): 76-81) Artykuł jest tłumaczeniem pracy: Katarzyna A. Miśkiewicz-Orczyk, Grażyna Lisowska, Dariusz Kajdaniuk, Mateusz Wojtulek. Can Hashimoto's thyroiditis cause vertigo? Endokrynol Pol 2020; 71 (1): 76-81. Należy cytować wersję pierwotną. Piśmiennictwo dostępne w wersji pierwotnej na stronach 79-81. Endokrynologia Polska Volume/Tom 71; Number/Numer 1/2020

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Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis

Cited by 57 publications

References 22 publications

Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Effect of Vitamin D Injection in Recurrent Benign Paroxysmal Positional Vertigo with Vitamin D Deficiency

Hypovitaminosis D, Low Bone Mineral Density, and Diabetes Mellitus as Probable Risk Factors for Benign Paroxysmal Positional Vertigo in the Elderly

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

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