Association of Barrett’s esophagus with Helicobacter pylori infection: a meta-analysis

Abstract

Background and Aims: Barrett’s esophagus (BE) is the only recognized precursor for esophageal adenocarcinoma. Helicobacter pylori ( H. pylori) infection is a major contributing factor towards upper gastrointestinal diseases, but its relationship with BE remains controversial. Some previous studies suggested that H. pylori infection negatively correlated with BE, while others did not. This may be attributed to the difference in the selection of control groups among studies. The present meta-analysis aims to clarify their association by combining all available data from well-designed studies. Methods: The PubMed, EMBASE, and Cochrane Library databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled by a random-effects model. Heterogeneity was evaluated using the Cochran’s Q test and I2 statistics. Meta-regression, subgroup, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity. Results: Twenty-four studies with 1,354,369 participants were included. Meta-analysis found that patients with BE had a significantly lower prevalence of H. pylori infection than those without (OR = 0.53, 95% CI = 0.45–0.64; p < 0.001). The heterogeneity was statistically significant ( I² = 79%; p < 0.001). Meta-regression, subgroup, and leave-one-out sensitivity analyses did not find any source of heterogeneity. Meta-analysis of 7 studies demonstrated that CagA-positive H. pylori infection inversely correlated with BE (OR = 0.25, 95% CI = 0.15–0.44; p = 0.000), but not CagA-negative H. pylori infection (OR = 1.22, 95% CI = 0.90–1.67; p = 0.206). Meta-analysis of 4 studies also demonstrated that H. pylori infection inversely correlated with LSBE (OR = 0.39, 95% CI = 0.18–0.86; p = 0.019), but not SSBE (OR = 0.73, 95% CI = 0.30–1.77; p = 0.484). Conclusion: H. pylori infection negatively correlates with BE. More experimental studies should be necessary to elucidate the potential mechanisms in future.

How big five personality traits influence information sharing on social media: A meta analysis

“…Fig 2 visually displays the significant publication bias present in our chosen papers. We employed the Leave-one-out method for sensitivity analysis to remove the most extreme outlier studies [ 36 , 37 ].…”

A global bibliometric and visualized analysis of the status and trends of gastroparesis research

“…We conducted a search for all publications in the gastroparesis field in the Science Citation Index-Expanded (SCIE) database in the WOS Core Collection (WOSCC), for the period spanning from database inception to November 16, 2022. The search terms were formulated based on the clinical experience, medical subject headings (MeSH), and published articles [ 18 , 19 ], and a title search was finally performed on the retrieved articles to avoid the inclusion of a large number of unrelated articles [ 20 – 22 ]. The search formula was finally set as follows: TI = (Gastropares*) OR TI = (Gastric Stas*).…”

Impact of Helicobacter pylori Status on GERD, Barrett’s Esophagus and Esophageal Cancer

“…[40][41][42] Table 2 summarizes five meta-analyses of observational studies evaluating the association between H. pylori infection and BE. 43- 47 Wang et al showed no significant difference in the overall prevalence of H. pylori infection in BE and healthy controls. 43 Subgroup analysis favored a lower prevalence of H. pylori infection in BE patients.…”