1990
DOI: 10.1002/art.1780330829
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Association of autoantibodies to myeloperoxidase with different forms of vasculitis

Abstract: Antineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase (MPO) were found in 53 patient sera that were routinely submitted for antineutrophil cytoplasmic antibody determination. Based on clinical and histologic criteria, 15 of these 53 patients were classified as having systemic necrotizing vasculitis of the polyarteritis group, 11 patients were classified as having Wegener's granulomatosis (WG), and 14 were classified as having idiopathic crescentic glomerulonephritis. The remaining 13 p… Show more

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Cited by 178 publications
(33 citation statements)
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(19 reference statements)
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“…Thereafter, it was recognized that ANCA was observed in GPA [53] and that the target antigen of ANCA in these patients was proteinase 3. Furthermore, MPO was found to be the target antigen in patients with PR3-ANCA-negative GPA, MPA and/or EGPA [14,54,55]. Importantly, patients with necrotizing glomerulonephritis are nearly always ANCA positive [14,55] while ANCA are not always found in a subgroup of patients with more limited disease [56,57].…”
Section: Serial Anca Measurements -A Historical Perspectivementioning
confidence: 98%
See 1 more Smart Citation
“…Thereafter, it was recognized that ANCA was observed in GPA [53] and that the target antigen of ANCA in these patients was proteinase 3. Furthermore, MPO was found to be the target antigen in patients with PR3-ANCA-negative GPA, MPA and/or EGPA [14,54,55]. Importantly, patients with necrotizing glomerulonephritis are nearly always ANCA positive [14,55] while ANCA are not always found in a subgroup of patients with more limited disease [56,57].…”
Section: Serial Anca Measurements -A Historical Perspectivementioning
confidence: 98%
“…Furthermore, MPO was found to be the target antigen in patients with PR3-ANCA-negative GPA, MPA and/or EGPA [14,54,55]. Importantly, patients with necrotizing glomerulonephritis are nearly always ANCA positive [14,55] while ANCA are not always found in a subgroup of patients with more limited disease [56,57]. The presence of PR3-or MPO-ANCA in AAV has been undisputed and has been incorporated in the current classification schemes [12,15].…”
Section: Serial Anca Measurements -A Historical Perspectivementioning
confidence: 99%
“…Although ANCA can be induced by certain infections, they are an AAV hallmark for which there are circulating ANCA that primarily target myeloperoxidase (MPO-ANCA) or serine protease proteinase 3 (PR3-ANCA) [38]. It should be noted that AAV can be accompanied by both MPO-ANCA and PR3-ANCA [33,39].…”
Section: Anti-neutrophil Cytoplasmic Antibody-associated Vasculitidesmentioning
confidence: 99%
“…Antineutrophil cytoplasmic antibodies (ANCA) directed against lysosomal enzymes of neutrophils and monocytes. in particular Proteinase 3 and myeloperoxidase, have been (ound to be strongly associated with this disease and other forms of idiopathic necrotizing vasculitis and crcscentic glomeruloiiephritis [2][3][4][5][6]. Changes In levels of these antibodies correlate closely with disease activity, which may suggest a pathophysiologieal role for these autoantibodies [2,7,8J. Apart from humoral mechanisms, cell-mediated immunity may also be involved in thepalhogenesisofWG [9], A role for T cell involvement in WG is suggested by the presence of granulomas, which points to T cell-mediated delayed type hypersensitivity reactions lo an as yet unknown stimulus.…”
Section: Introductionmentioning
confidence: 99%