Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Lee, Maunoo; Krishnamurthy, Jayasree; Susi, Apryl; Sullivan, Connor; Gorman, Gregory; Hisle-Gorman, Elizabeth; Erdie-Lalena, Christine; Nylund, Cade M.

doi:10.1007/s10803-017-3409-5

Cited by 62 publications

(45 citation statements)

References 23 publications

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“…The analysis regarding the two control diseases, UC and malaria, showed that previously reported direct epidemiological associations between diseases translate into similar patterns of transcriptomic deregulation between them. The increased risk of UC in ASD patients observed at a population level(57) was followed by significant same direction deregulation patterns between both diseases at a transcriptomic level. Similarly, significant same direction transcriptomic changes were observed between UC and colorectal cancer (CRC), two diseases with a known direct epidemiologic link.…”

Section: Discussionmentioning

confidence: 82%

“…To evaluate the level of specificity of the reported associations between ASD and cancer and determine if associations with previous epidemiological confirmation translate in same or opposite direction deregulation patters, ASD and cancer differential expression profiles were compared to two control diseases, ulcerative colitis (UC) and malaria. Ulcerative colitis has been shown to have direct comorbid associations with both ASD and colorectal cancer (CRC) (57, 58). UC differential expression profile was found to be deregulated in the same direction as both, ASD and colorectal cancer ( Supplementary Figure 7 A ).…”

Section: Resultsmentioning

confidence: 99%

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Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

Martos

Catalá-López

Valle

et al. 2018

Preprint

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Epidemiological and clinical evidence points to cancer as a comorbidity in people with autism spectrum disorders (ASD). A significant overlap of genes and biological processes between both diseases has also been reported. Here, for the first time, we compared the gene expression profiles of ASD frontal cortex tissues and 22 cancer types obtained by differential expression meta-analysis. Four cancer types (brain, thyroid, kidney, and pancreatic cancers) presented a significant overlap in gene expression deregulations in the same direction as ASD whereas two cancer types (lung and prostate cancers) showed differential expression profiles significantly deregulated in the opposite direction from ASD. Functional enrichment and LINCS L1000 based drug set enrichment analyses revealed the implication of several biological processes and pathways that were affected jointly in both diseases, including impairments of the immune system, and impairments in oxidative phosphorylation and ATP synthesis among others. Our data also suggest that brain and kidney cancer have patterns of transcriptomic dysregulation in the PI3K/AKT/MTOR axis that are similar to those found in ASD. These shared transcriptomic alterations could help explain epidemiological observations suggesting direct and inverse comorbid associations between ASD and particular cancer types.

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Section: Discussionmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

Martos

Catalá-López

Valle

et al. 2018

Preprint

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“…A recent study concluded that IBD is more prevalent in children with ASD than in children without ASD, and that there is an association between ASD and IBD. 16 Children with ASD are often nonverbal and may have difficulties with communication. Therefore, transitional care for ASD patients with child-onset IBD is challenging, and such patients should be treated individually in a coordinated manner using a multidisciplinary approach.…”

Section: Discussionmentioning

confidence: 99%

Adult gastroenterologists’ views on transitional care: Results from a survey

Kumagai

Kudo

Uchida

et al. 2019

Pediatrics International

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Background: In 2018, Japanese guidelines for autonomy support of patients with inflammatory bowel disease (IBD) in the transitional period were published. These guidelines, however, were prepared mainly by pediatric gastroenterologists. In order to improve such supportive guidelines, it is necessary for pediatric gastroenterologists to be aware of the attitudes and expectations of adult gastroenterologists. Accordingly, the first Japanese national survey designed to explore the views of adult gastroenterologists regarding successful transitional care was conducted. Methods: The survey involved institutions at which adult gastroenterologists in the Ministry of Health, Labor and Welfare of Japan's Inflammatory Bowel Diseases Study Group, were working. Physicians were contacted by conventional mail, and their answers were not anonymized. A total of 100 eligible adult institutions were identified. Further specific subgroup analysis was conducted. Results: A response rate of 34% was achieved. Seventy-six percent of the respondents had experienced some degree of difficulty when accepting patients with childhood-onset IBD referred from pediatric gastroenterologists. With regard to the ideal form of medical care for adolescent patients with IBD, transfer to adult care was supported by 94% of the respondents. Only 27% of respondents, however, stated they would have no hesitation in accepting patients referred from pediatric care centers. Two crucial areas requiring improvement were identified: inadequate clinical summaries and lack of patient independence from their parents/caregivers. Conclusions: The present survey results reinforce the importance of a transitional program of education for childhood-onset IBD patients and the need to improve communication between adult and pediatric gastroenterologists.

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“…MCHR1 mRNA showed a five-fold increase in patients with Crohn's disease, and enteric epithelial cells show up-regulated MCHR1 expression under inflammatory conditions [133]. Enteric nervous system and GI tract inflammation have been found at high rates among patients with ASD [142,265], with cytokines such as IL-6 [31] implicated in these disturbances [211]. Several pro-inflammatory cytokines are transcriptionally regulated by MCH, and in patients with inflammatory bowel disease MCH was found to stimulate IL-8 production [133] which promotes local recruitment of immune cellswhile preventing up-regulation of anti-inflammatory cytokine IL-10 [285].…”

Section: Enteric Nervous System Dysregulationmentioning

confidence: 99%

Pathogenicity of Endocrine Dysregulation in Autism: The Role of the Melanin-Concentrating Hormone System

Swierczynski¹

2019

SciMed. J.

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The voluminous daily output of autism research has become increasingly disconnected, existing largely within highly specific subspecialty areas, and lacking cross-disciplinary linkages of context, theory, and findings to inform a unified body of knowledge. Robust syntheses of published research across the fields of psychiatry, cellular and molecular biology, neurology, endocrinology, immunology, behavioral and social sciences, and pedagogy may help clarify and extend current knowledge by guiding more efficient future research efforts investigating underlying causes, developmental divergences, novel treatments, and specific, sensitive biological markers in autism. This synthesis of interdisciplinary research indicates the hypothalamic-pituitary-adrenal (HPA) stress axis may be at the center of an interaction among sex steroids, immune function, signaling protein transcriptions, neurogenesis, and dysregulation of brain structures sending or receiving projections from the HPA stress axis. These interactions manifest observably as a range of sexually dimorphic behaviors and functional limitations often falling within the current diagnostic features of Autism Spectrum Disorder (ASD). The pathogenicity of endocrine dysregulation may serve as a valuable model for developing a cohesive theory of ASD by explaining how the HPA and connected brain areas respond to extreme conditions of dysregulated endocrine signaling to cause symptoms associated with autism.

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Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Cited by 62 publications

References 23 publications

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer

Adult gastroenterologists’ views on transitional care: Results from a survey

Pathogenicity of Endocrine Dysregulation in Autism: The Role of the Melanin-Concentrating Hormone System

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