Association of Atrial Fibrillation and Obstructive Sleep Apnea

Gami, Apoor S.; Pressman, Gregg S.; Caples, Sean M.; Kanagala, Ravi; Gard, Joseph J.; Davison, Diane E.; Malouf, Joseph F.; Ammash, Naser M.; Friedman, Paul A.; Somers, Virend K.

doi:10.1161/01.cir.0000136587.68725.8e

Cited by 979 publications

(403 citation statements)

References 32 publications

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“…242 An estimated 50% of atrial fibrillation patients presenting for cardioversion are likely to have OSA compared with an Ϸ30% likelihood of OSA in a general cardiology clinic population. 243 The role of atrial fibrillation in any increased risk of stroke in patients with OSA remains to be determined. 214 Ventricular Arrhythmias.…”

Section: Prevalence Of Arrhythmias In Sleep Apneamentioning

confidence: 99%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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Section: Prevalence Of Arrhythmias In Sleep Apneamentioning

confidence: 99%

Sleep Apnea and Cardiovascular Disease

et al. 2008

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“…In patients with atrial fibrillation, the prevalence of OSA has been found to be between 21% and 49% [64,65], and it is higher in patients with lone atrial fibrillation, compared to matched control subjects with other cardiovascular disease (49% versus 32%) [64,66].…”

Section: Observational Studies Regarding Atrial Fibrillationmentioning

confidence: 99%

Effects of obstructive sleep apnoea on heart rhythm

2012

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Symptomatic obstructive sleep apnoea (OSA) has been proven to be a risk factor for hypertension and vascular dysfunction, and has been proposed to be causally related with cardiac arrhythmias and sudden cardiac death.Searches of bibliographical databases revealed that several mechanisms seem to underpin the association between OSA and cardiac arrhythmias: intermittent hypoxia associated with autonomic nervous system activation and increased oxidative stress, which may lead to cardiac cellular damage and alteration in myocardial excitability; recurrent arousals, resulting in sympathetic activation and coronary vasoconstriction; and increased negative intrathoracic pressure which may mechanically stretch the myocardial walls and, thus, promote acute changes in myocardial excitability as well as structural remodelling of the myocardium.Findings from cross-sectional studies suggest a high prevalence of cardiac arrhythmias in patients with OSA and a high prevalence of OSA in those with cardiac arrhythmias. Preliminary evidence from uncontrolled interventional studies suggests that treatment of OSA may prevent cardiac arrhythmias.In conclusion, there is preliminary evidence that OSA is associated with the development of cardiac arrhythmias. Data from randomised controlled studies are needed to definitively clarify the role of OSA in arrhythmogenesis.

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“…15 Furthermore, SF-36 does not assess sleep quality. Sleep-disordered breathing, which is more prevalent in AF patients, 16 may cause disrupted sleep and has been associated with poor HRQoL. 17 Sleep impairment is associated with anxiety and depression.…”

Section: Introductionmentioning

confidence: 99%

Mental Health and Sleep in Permanent Atrial Fibrillation Patients From the General Population

Ariansen

Dammen

Abdelnoor

et al. 2011

Clinical Cardiology

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Background:Anxiety and depression has been found in atrial fibrillation (AF) patients referred to secondary care. Little is known about the level of such distress in AF patients from the general population.Hypothesis:Permanent AF patients from the general population might have more anxiety, depression, and sleep impairment than subjects in sinus rhythm.Methods:Patients with permanent AF and controls in sinus rhythm were recruited from a 75‐year‐old cohort from 2 Norwegian municipalities. The main outcome variables were anxiety and depression, measured by the Hospital Anxiety and Depression Scale (HADS) and sleep quality measured by Pittsburgh Sleep Quality Index (PSQI) score. Short Form 36 (SF‐36) was also completed.Results:Twenty‐seven patients with permanent AF and 71 subjects in sinus rhythm participated. No significant score differences were found between AF patients and controls for HADS anxiety (median, inter quartile range, 3 [1, 5] vs 4 [1, 6]; HADS depression, 3 [1,6] vs 2 [1,4]; and PSQI 6 [3, 11] vs 5 [4, 8]). AF patients had significantly poorer scores for SF‐36 physical functioning, physical role, general health, vitality, and social functioning compared to subjects in sinus rhythm.Conclusions:Elderly permanent AF patients from the general population had similar levels of anxiety, depression, and sleep quality, despite poorer physical health‐related quality of life compared to controls in sinus rhythm. Copyright © 2011 Wiley Periodicals, Inc.This work was supported by unrestricted grants from the governmental Health Region South‐East, Norway, and from the Stein Erik Hagen Foundation for Clinical Heart Research, Norway. The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Association of Atrial Fibrillation and Obstructive Sleep Apnea

Cited by 979 publications

References 32 publications

Sleep Apnea and Cardiovascular Disease

Sleep Apnea and Cardiovascular Disease

Effects of obstructive sleep apnoea on heart rhythm

Mental Health and Sleep in Permanent Atrial Fibrillation Patients From the General Population

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