Association of atopic dermatitis with smoking: A systematic review and meta-analysis

Kantor, Robert; Kim, Ashley; Thyssen, Jacob P.; Silverberg, Jonathan I.

doi:10.1016/j.jaad.2016.07.017

Cited by 196 publications

(185 citation statements)

References 43 publications

(43 reference statements)

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“…The prevalence of smoking was higher in severe AE, as shown in a recent cross‐sectional study investigating the entire Danish population . A systematic review of 86 studies confirmed the association between smoking and AE in adolescents and adults in all continents of the earth . It remains unclear, however, whether smoking is a provocation factor in AE or whether the burden of AE leads to more frequent smoking habits …”

Section: General Measures and Avoidance Strategiesmentioning

confidence: 76%

See 1 more Smart Citation

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Wollenberg

Barbarot

Bieber³

et al. 2018

Acad Dermatol Venereol

836

1,014

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This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions. Management of AE must consider the individual clinical variability of the disease; highly standardized treatment rules are not recommended. Basic therapy is focused on treatment of disturbed barrier function by hydrating and lubricating topical treatment, besides further avoidance of specific and unspecific provocation factors. Topical anti-inflammatory treatment based on glucocorticosteroids and calcineurin inhibitors is used for flare management and for proactive therapy for long-term control. Topical corticosteroids remain the mainstay of therapy, whereas tacrolimus and pimecrolimus are preferred in sensitive skin areas and for long-term use. Topical phosphodiesterase inhibitors may be a treatment alternative when available. Adjuvant therapy includes UV irradiation, preferably with UVB 311 nm or UVA1. Pruritus is targeted with the majority of the recommended therapies, but some patients may need additional antipruritic therapy. Antimicrobial therapy, systemic anti-inflammatory treatment, immunotherapy, complementary medicine and educational intervention will be addressed in part II of the guideline.

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Section: General Measures and Avoidance Strategiesmentioning

confidence: 76%

“…A systematic review of 86 studies confirmed the association between smoking and AE in adolescents and adults in all continents of the earth . It remains unclear, however, whether smoking is a provocation factor in AE or whether the burden of AE leads to more frequent smoking habits …”

Section: General Measures and Avoidance Strategiesmentioning

confidence: 93%

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Wollenberg

Barbarot

Bieber³

et al. 2018

Acad Dermatol Venereol

836

1,014

View full text Add to dashboard Cite

show abstract

“…(Table S1; see Supporting Information). In a recent meta‐analysis, AD was significantly associated with smoking, thereby suggesting yet another causative factor for CVD . Patients with AD often suffer from poor and interrupted sleep, mostly resulting from itch, but psychiatric disorders such as attention deficit hyperactivity disorder, anxiety and depression may also play a role.…”

Section: Discussionmentioning

confidence: 99%

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

et al. 2018

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“…An SR assessing 86 observational studies (680 176 subjects, 65 173 with AE) found that self‐reported active and passive exposure to cigarette smoke was associated with a higher prevalence of AE in children and adults (OR = 1.87, 95% CI 1.32–2.63 active smokers; OR = 1.18, 95% CI 1.01–1.38 passive smokers). Although the terms were not defined by the authors, no dose–response relationship was seen when comparing ‘mild’ vs. ‘extensive’ amounts of smoking exposure.…”

Section: Risk Factorsmentioning

confidence: 99%

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors

et al. 2019

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Summary This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It presents the key findings from 14 systematic reviews published in 2016, focusing on AE epidemiology, aetiology and risk factors. For systematic reviews on the treatment and prevention of AE and for nomenclature and outcome assessments, see Parts 1 and 3 of this update, respectively. The annual self‐reported prevalence of AE is a range of 11.4–24.2%, compared with a general practioner‐diagnosed prevalence of 1.8–9.5%. The mean age of AE diagnosis is 1.6 years. Persistent AE is associated with more severe disease at the time of diagnosis, onset after the age of 2 years and female sex. There is a significant association between having AE and subsequent development of food allergy. Food allergy is also associated with more severe and persistent AE. No consistent association was found between the timing of allergenic food introduction and the risk of developing AE. Evidence from heterogeneous studies indicates that skin absorption is increased in patients with AE, and that there is increased colonization with Staphylococcus aureus in lesional and nonlesional skin and the nasal mucosa of patients with AE compared with controls. There is uncertain evidence indicating an association between AE and smoking exposure, antenatal infection and low maternal vitamin D levels during pregnancy. Weak evidence suggests an increased risk of basal cell carcinoma, but not of melanoma or squamous cell carcinoma, while the risk of glioma is reduced.

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Association of atopic dermatitis with smoking: A systematic review and meta-analysis

Abstract: Active and passive exposure to smoke are associated with increased AD prevalence.

Cited by 196 publications

References 43 publications

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 2: Epidemiology, aetiology and risk factors

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