Association of Atherosclerosis with Low Back Pain and the Degree of Disc Degeneration

Kurunlahti, Mauno; Tervonen, Osmo; Vanharanta, Heikki; Ilkko, E.; Suramo, I

doi:10.1097/00007632-199910150-00003

Cited by 105 publications

(68 citation statements)

References 13 publications

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“…Typically, atherosclerotic lesions occur in the bifurcation region, where the orifices of the lumbar arteries are located [6]. Consistently, it has been suggested that atherosclerotic arterial occlusion in the supplying arteries leads progressive disc degeneration and back symptoms due to a decrease in the nutrition of the disc tissue [5,6,21].…”

Section: Discussionmentioning

confidence: 98%

“…It is well-known that blood supply of the lumbar intervertebral disc, the largest avascular tissue in the human body, is provided by the branches of the abdominal aorta [5,6,21]. Typically, atherosclerotic lesions occur in the bifurcation region, where the orifices of the lumbar arteries are located [6].…”

Section: Discussionmentioning

confidence: 99%

“…The lower abdominal aorta from L3 to L5 was evaluated for calcifications, which were graded on the basis of the size of the largest plaque seen in all images into four grades: 0, no calcifications; 1, aortic wall calcifications involving less than one third of the aortic circumference in a cross-sectional image of the aorta; 2, aortic wall calcifications occupying one third to two thirds of the aortic circumference; and 3, calcifications comprising more than two thirds of the aortic circumference [6], see Table 3.…”

Section: Degree Of Aortic Wall Calcificationmentioning

confidence: 99%

“…Numerous studies have also confirmed that atherosclerotic lesions increase with age [5,6]. Although, it has been suggested that insufficient blood supply in the feeding arteries of the lumbar spine owing to atherosclerosis in the abdominal aorta may be a causative factor in disc degeneration, the precise cause for the dramatic degenerative changes in the intervertebral disc tissue still remains unclear [1,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…This hypothesis is based on the following observations: (a) MEL secretion decreases with advanced age, a period associated with an increased risk of development of disc degeneration and atherosclerotic calcifications [5,6]; (b) obesity, which is a major risk factor for DDD and atherosclerosis, is associated with impaired circadian MEL secretion [13,14]; (c) diabetes mellitus, which is an additional risk factor for DDD and atherosclerosis, is associated with decreased MEL secretion and an increased rate of pineal calcification [15,16]; and (d) significant difference in the presence as well as severity of degenerated disc, aortic atherosclerosis, and pineal calcification according to ethnicity [8,17,18].To test our hypothesis, we designed a cross-sectional observational radiological study to investigate the correlations between pineal gland calcification, intervertebral disc degeneration and abdominal aorta atherosclerosis in subjects with low back pain to clarify the possible impact of pineal gland calcification.…”

Section: Introductionmentioning

confidence: 99%

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Pineal gland calcification, lumbar intervertebral disc degeneration and abdominal aorta calcifying atherosclerosis correlate in low back pain subjects: A cross-sectional observational CT study

et al. 2008

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Degree Of Aortic Wall Calcificationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pineal gland calcification, lumbar intervertebral disc degeneration and abdominal aorta calcifying atherosclerosis correlate in low back pain subjects: A cross-sectional observational CT study

et al. 2008

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Association of Severe Disc Degeneration With All‐Cause Mortality and Abdominal Aortic Calcification Assessed Prospectively in Older Men: Findings of a Single‐Center Prospective Study of Osteoporosis in Men

Estublier

Chapurlat

Szulc

2015

Arthritis & Rheumatology

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Objective. To assess the association of disc degeneration with all-cause mortality and with the severity and rate of progression of abdominal aortic calcification (AAC) in older men.Methods. Men >50 years of age (n 5 766) underwent lateral spine radiography and blood collection and were monitored prospectively. We assessed the association of disc degeneration with all-cause mortality (at 10 years), AAC severity (at baseline), and AAC progression (at 7.5 years).Results. After adjustment for confounders, including AAC, the total overall grade score for AAC predicted all-cause mortality (hazard ratio [HR] 1.20 per SD increase [95% confidence interval (95% CI) 1.01-1.43]). The highest tertile of the total overall grade score was associated with higher mortality rates (39.3/ 1,000 person-years for a score of >8 versus 20.9/1,000 person-years for a score of 0-8; adjusted HR 1.47 [95% CI 1.05-2.06]). The odds of severe AAC (score of >5) increased with the total disc space narrowing score (adjusted HR 1.44 per SD [95% CI 1.11-1.87]). The highest tertile of the total disc space narrowing score was associated with higher odds of severe AAC (adjusted HR 2.42 versus the lowest tertile [95% CI 1.24-4.73]). The probability of long-term AAC stability decreased with an increasing total osteophyte score (adjusted HR 0.66 per SD [95% CI 0.49-0.88]). The highest tertile of the total osteophyte score was associated with a lower probability of AAC stability (adjusted HR 0.35 versus the lowest tertile [95% CI 0.18-0.71]).Conclusion. Older men with severe disc degeneration have greater AAC severity, faster AAC progression, and higher all-cause mortality rates.

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Factors associated with seeking medical care for low back pain in a twin adult sample

Ferreira

Pinheiro

et al. 2021

European Journal of Pain

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Background: Previous studies have only investigated how symptom presentation and socio-demographic factors influence care-seeking for low back pain (LBP).However, the influence of health and lifestyle factors remains unclear, and the potential confounding effects of aggregated familial factors (including genetics and the early shared environment) has not been considered extensively. Methods: A cross-sectional analysis was performed on 1605 twins enrolled in the Murcia Twin Registry (Spain). The outcome was seeking medical care for LBP and various self-reported demographic, health and lifestyle factors were considered predictors. All variables except sleep quality and diabetes were collected in 2013, which were cross-referenced from 2009 to 2010. A multivariate logistic regression model was performed on the total sample, followed by a co-twin case-control analysis. Results: The only significant factor found to increase the odds of seeking medical care for LBP without being affected by familial factors was poor sleep quality (total sample OR = 1.58, 95%CI 1.24-2.01; case-control OR = 1.75, 95%CI 1.14-2.69).The factors that were associated with reduced odds of seeking medical care for LBP and not confounded by familial factors were male sex (case-control OR = 0.55, 95%CI 0.33-0.93), alcohol intake (case-control OR = 0.90, 95%CI 0.82-0.99) and a history of diabetes (case-control OR = 0.50, 95%CI 0.25-0.97). No other factors significantly influenced medical care-seeking for LBP. Conclusions: People reporting poor sleep quality are more likely to seek medical care for LBP in the long term, with this relationship being independent from aggregated familial factors. Conversely, males, people reporting higher alcohol intake, and people with a history of diabetes are less likely to seek medical care for LBP. Significance: This is the first study investigating the factors that influence seeking medical care for LBP, while adjusting for the influence of familial factors using a co-twin control design. Poor sleep quality is associated with seeking medical care for LBP in the long term and does not appear to be confounded by familial factors. Early screening for indicators of poor sleep quality and appropriate referral to interventions for improving sleep quality or reducing pain in sleep may improve LBP management.

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Association of Atherosclerosis with Low Back Pain and the Degree of Disc Degeneration

Abstract: A significant association is indicated between atheromatous lesions in the abdominal aorta and low back pain.

Cited by 105 publications

References 13 publications

Pineal gland calcification, lumbar intervertebral disc degeneration and abdominal aorta calcifying atherosclerosis correlate in low back pain subjects: A cross-sectional observational CT study

Pineal gland calcification, lumbar intervertebral disc degeneration and abdominal aorta calcifying atherosclerosis correlate in low back pain subjects: A cross-sectional observational CT study

Association of Severe Disc Degeneration With All‐Cause Mortality and Abdominal Aortic Calcification Assessed Prospectively in Older Men: Findings of a Single‐Center Prospective Study of Osteoporosis in Men

Factors associated with seeking medical care for low back pain in a twin adult sample

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