Association of Asymmetric Dimethylarginine With Acute Pancreatitis–Induced Hyperglycemia

Trgo, Gorana; Žaja, Ivan; Bogut, Ante; Vicić, Vesna Kovačić; Meter, I.D.; Lovrenčić, Marijana Vučić; Radman, Miroslav

doi:10.1097/mpa.0000000000000516

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…In a study that inspired our research, patients with AP were staged according to Atlanta criteria. [17] The ADMA reduction was more pronounced between the two sequential samplings in moderately severe patients. Moreover, they found impaired glucose tolerance to be higher in the moderately severe group after recovery and correlated this with ADMA levels.…”

Section: Discussionmentioning

confidence: 91%

Akut Pankreas İltihabı Süresince Metillenmiş Arginin Rezidüleri ve İlişkili Amino Asitlerdeki Değişimler

CİZMECİOGLU

Onmaz

AYDİN

et al. 2022

Journal of Contemporary Medicine

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Aim: The extent of the spread of inflammation determines the severity of acute pancreatitis (AP). Methylated arginine residues (MAR), a type of inflammatory mediator, reduce nitric oxide levels and cause vasoconstriction-induced endothelial damage. This study aimed to investigate MAR and related amino acids during acute pancreatic inflammation. Material and Method: This prospective, quasi-experimental study was conducted with patients diagnosed with AP and an age-matched control group. The patient samples were taken during the diagnosis and recovery time, whereas during the study for the control group. Mainly, Asymmetric dimethylarginine (ADMA), Arginine (ARG), Citrulline (CIT), and related chemicals were studied via a mass spectrometer. Results: A total of 30 patients with AP (mean age=53.3±17.8) and 30 controls (mean age=53.4±18.0) were included in the study. All patients were identified as non-severe (n=8) and severe (n=22). A decrease was detected in the patients' ADMA levels compared to the control group (p=0.01). MAR did not differ concerning disease severity (p > 0.05). However, MAR levels decreased higher in patients with diabetes or chronic kidney disease (CKD). Between the two samplings, the ARG level and ARG to ADMA ratio increased, while the MAR and CIT to ARG ratio decreased. Conclusion: Our results showed that MAR levels decreased with AP recovery. The start of a decrease in the high-level blood MAR may indicate the healing of pancreatic inflammation. AP inflammation may be more destructive in patients with diabetes or CKD.

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Section: Discussionmentioning

confidence: 91%

Akut Pankreas İltihabı Süresince Metillenmiş Arginin Rezidüleri ve İlişkili Amino Asitlerdeki Değişimler

CİZMECİOGLU

Onmaz

AYDİN

et al. 2022

Journal of Contemporary Medicine

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“…Weitz G (28) 2014 391 Severity Classification Germany Karabulut U (29) 2014 98 Severity Classification Brazil Murilo GB (30) 2016 58 Severity Classification Brazil Sun Y (31) 2015 43 Severity Classification China Zhu Y (32) 2017 3260 Severity Classification China Zeng Y (33) 2014 90 Severity Classification China Li G (34) 2016 35 Diagnosis China Deng LH (16) 2017 70 Severity Classification China Lin S (35) 2017 671 Severity Classification China Qi X (36) 2017 204 Severity Classification China Jia R (37) 2015 85 Severity Classification China Xiao S (38) 2015 153 Diagnosis China Joon HC (39) 2015 153 Severity Classification South Korea Huh JH (40) 2018 191 Severity Classification South Korea Kim BG (41) 2013 50 Severity Classification / Diagnosis South Korea Cho JH (42) 2018 60 Severity Classification South Korea Mikolasevic (43) 2016 198 Severity Classification Croatia Mikolasevic (44) 2016 609 Severity Classification / Diagnosis Croatia Trgo G (45) 2016 40 Severity Classification Croatia Vujasinovic (46) 2014 100 Severity Classification Slovenia María CP (47) 2016 56 Severity Classification Spain Bozhychko (48) 2017 233 Severity Classification Spain Ellery KM (49) 2017 122 Severity Classification / Diagnosis USA Sugimoto M (50) 2015 663 Severity Classification USA Gougol A (51) 2017 500 Severity Classification USA Vipperla K (52) 2017 121 Severity Classification USA Vlada AC (53) 2013 67 Severity Classification USA Buxbaum J (54) 2014 25 Severity Classification USA Buxbaum J (55) 2016 60 Severity Classification USA Dimagno M (56) 2014 223 Diagnosis USA Bishu S (57) 2018 357 Severity Classification USA Bem MD (58) 2016 175 Severity Classification USA Nieminen A …”

Section: Author Publication Year Number Of Participants Adopted Atlanta Revision Criteria Nationalitymentioning

confidence: 99%

The Acceptance of Changes in the Management of Patients With Acute Pancreatitis After the Revised Atlanta Classification

Alves

Ferrazza

Nunes

et al. 2021

Arq. Gastroenterol.

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BACKGROUND: New recommendations for the management of patients with acute pancreatitis were set after the Atlanta Classification was revised in 2012. OBJECTIVE: The aim of the present systematic review is to assess whether these recommendations have already been accepted and implemented in daily medical practices. METHODS: A systematic literature review was carried out in studies conducted with humans and published in English and Portuguese language from 10/25/2012 to 11/30/2018. The search was conducted in databases such as PubMed/Medline, Cochrane and SciELO, based on the following descriptors/Boolean operator: “Acute pancreatitis” AND “Atlanta”. Only Randomized Clinical Trials comprising some recommendations released after the revised Atlanta Classification in 2012 were included in the study. RESULTS: Eighty-nine studies were selected and considered valid after inclusion, exclusion and qualitative evaluation criteria application. These studies were stratified as to whether, or not, they applied the recommendations suggested after the Atlanta Classification revision. Based on the results, 68.5% of the studies applied the recommendations, with emphasis on the application of severity classification (mild, moderately severe, severe); 16.4% of them were North-American and 14.7% were Chinese. The remaining 31.5% just focused on comparing or validating the severity classification. CONCLUSION: Few studies have disclosed any form of acceptance or practice of these recommendations, despite the US and Chinese efforts. The lack of incorporation of these recommendations didn’t enable harnessing the benefits of their application in the clinical practice (particularly the improvement of the communication among health professionals and directly association with the worst prognoses); thus, it is necessary mobilizing the international medical community in order to change this scenario.

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Metabolomics for clinical use and research in chronic kidney disease

2017

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Chronic kidney disease (CKD) has a high prevalence in the general population and is associated with high mortality; a need therefore exists for better biomarkers for diagnosis, monitoring of disease progression and therapy stratification. Moreover, very sensitive biomarkers are needed in drug development and clinical research to increase understanding of the efficacy and safety of potential and existing therapies. Metabolomics analyses can identify and quantify all metabolites present in a given sample, covering hundreds to thousands of metabolites. Sample preparation for metabolomics requires a very fast arrest of biochemical processes. Present key technologies for metabolomics are mass spectrometry and proton nuclear magnetic resonance spectroscopy, which require sophisticated biostatistic and bioinformatic data analyses. The use of metabolomics has been instrumental in identifying new biomarkers of CKD such as acylcarnitines, glycerolipids, dimethylarginines and metabolites of tryptophan, the citric acid cycle and the urea cycle. Biomarkers such as c-mannosyl tryptophan and pseudouridine have better performance in CKD stratification than does creatinine. Future challenges in metabolomics analyses are prospective studies and deconvolution of CKD biomarkers from those of other diseases such as metabolic syndrome, diabetes mellitus, inflammatory conditions, stress and cancer.

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Association of Asymmetric Dimethylarginine With Acute Pancreatitis–Induced Hyperglycemia

Abstract: Insufficient inhibition of nitric oxide synthesis, through reduced bioavailability of ADMA, might be a novel significant contributory factor to the severity of AP and subsequent development of hyperglycemia.

Cited by 5 publications

References 29 publications

Akut Pankreas İltihabı Süresince Metillenmiş Arginin Rezidüleri ve İlişkili Amino Asitlerdeki Değişimler

Akut Pankreas İltihabı Süresince Metillenmiş Arginin Rezidüleri ve İlişkili Amino Asitlerdeki Değişimler

The Acceptance of Changes in the Management of Patients With Acute Pancreatitis After the Revised Atlanta Classification

Metabolomics for clinical use and research in chronic kidney disease

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