Association of As, Pb, Cr, and Zn urinary heavy metals levels with predictive indicators of cardiovascular disease and obesity in children and adolescents

Nasab, Habibeh; Rajabi, Saeed; Eghbalian, Mostafa; Malakootian, Mohammad; Hashemi, Majid

doi:10.1016/j.chemosphere.2022.133664

Cited by 54 publications

(31 citation statements)

References 56 publications

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“…Consistent with other findings, our study reports that factors such as older age, education, relationship status, income, high RBC folate levels, multimorbidity, BMI, alcohol intake, and smoking are significantly associated with CVDs, DM, and depression [21][22][23][24][25][26][27][28]76]. However, there are some surprising results.…”

Section: Discussionsupporting

confidence: 90%

“…Chromium deficiency has been associated with DM and CVDs, such as atherosclerosis [18], and chromium supplementation has been reported to have beneficial effects on symptoms related to CVDs, type 2 DM, and depression [19,20]. It is also well known that these chronic physical and mental health conditions can result from complex interactions of socio-demographic, behavioral, environmental, psychological, and biological factors which can be catalyzed by challenging life events [21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

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Blood Chromium Levels and Their Association with Cardiovascular Diseases, Diabetes, and Depression: National Health and Nutrition Examination Survey (NHANES) 2015–2016

et al. 2022

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Currently, there is no global consensus about the essentiality of dietary chromium. To provide evidence to this debate, an examination of blood chromium levels and common chronic health conditions was undertaken. Using a subsample from the 2015–2016 US National Health and Nutrition Examination Survey (n = 2894; 40 years+), chi-square and binary logistic regression analyses were conducted to examine blood chromium levels (0.7–28.0 vs. <0.7 µg/L) and their associations with cardiovascular diseases (CVDs; self-report), diabetes mellitus (DM; glycohemoglobin ≥5.7%), and depression (Patient Health Questionnaire-9 score ≥5), while controlling for socio-demographic (age/sex/income/education/relationship status) and health-related (red blood cell folate/medications/co-morbidities/body mass index (BMI)/substance use) factors. The sample was almost evenly distributed between men and women (n = 1391, 48.1% (men); n = 1503, 51.9% (women)). The prevalence estimates of low blood chromium levels tended to be higher among those with CVDs (47.4–47.6%) and DM (50.0–51.6%). Comparisons between those with low vs. normal blood chromium levels indicate men have increased odds of CVDs (adjusted odds ratio (aOR) = 1.86, 95% confidence interval (CI): 1.22–2.85, p < 0.001) and DM (aOR = 1.93, 95% CI: 1.32–2.83, p < 0.001) and lower odds of depression (aOR = 0.42, 95% CI: 0.22–0.77, p < 0.05). Dietary chromium may be important in the prevention and management of CVDs and DM for men. Continued exploration of chromium’s role in chronic diseases, including differences by biological factors, is needed.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Blood Chromium Levels and Their Association with Cardiovascular Diseases, Diabetes, and Depression: National Health and Nutrition Examination Survey (NHANES) 2015–2016

et al. 2022

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“…In conclusion, our data demonstrated that NO treatment stimulated intracellular Zn 2+ mobilization through the GC/cGMP/PKG pathway, caused upregulation of adipocyte differentiation regulators such as PPARγ, C/EBPα, and aP2, and resulted in triglyceride accumulation in 3T3-L1 adipocytes ( Figure 9 ). The impact of zinc on obesity and its associated metabolic disorders has been shown in a study by Nasab and coworkers [ 44 ]. Their data showed that urinary Zn 2+ concentrations are greater in obese adults and that zinc levels are significantly associated with fasting blood sugar and lipid metabolites including cholesterol, triglyceride, LDL, and HDL.…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Mobilizes Intracellular Zn2+ via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation

Chen

Huang

et al. 2022

IJMS

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Plasma and tissue zinc ion levels are associated with the development of obesity. Previous studies have suggested that zinc ions may regulate adipocyte metabolism and that nitric oxide (NO) plays a pivotal role in the regulation of adipocyte physiology. Our previous study showed that chronic NO deficiency causes a significant decrease in adipose tissue mass in rats. Studies also suggested that zinc ions play an important modulatory role in regulating NO function. This study aims to explore the role of zinc ions in NO-regulated adipocyte differentiation. We hypothesized that NO could increase intracellular Zn2+ level and then stimulate adipocyte differentiation. ZnCl2 and the NO donor, NONOate, were used to explore the effects of Zn2+ and NO on adipocyte differentiation. Regulatory mechanisms of NO on intracellular Zn2+ mobilization were determined by detection. Then, Zn2+-selective chelator TPEN was used to clarify the role of intracellular Zn2+ on NO-regulated adipocyte differentiation. Furthermore, the relationship between adipocyte size, Zn2+ level, and NOS expression in human subcutaneous fat tissue was elucidated. Results showed that both ZnCl2 and NO stimulated adipocyte differentiation in a dose-dependent manner. NO stimulated intracellular Zn2+ mobilization in adipocytes through the guanylate cyclase (GC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway, and NO-stimulated adipocyte differentiation was Zn2+-dependent. In human subcutaneous adipose tissue, adipocyte size was negatively correlated with expression of eNOS. In conclusion, NO treatment stimulates intracellular Zn2+ mobilization through the GC/cGMP/PKG pathway, subsequently stimulating adipocyte differentiation.

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“…Paparan logam Cr pada tubuh manusia khususnya pada anak-anak dan remaja disinyalir dapat berdampak pada obesitas dan menunjukkan tandatanda penyakit kardiovaskular. 40 Rata-rata nilai asupan harian/estimated daily intake (EDI) logam berat pada anak-anak, remaja, dewasa, dan manula dapat dilihat pada Gambar 2. Asupan harian logam Zn yang paling besar dibanding dengan logam lainnya pada semua kategori umur yaitu sebesar 8.28x10 -5 , sedangkan asupan harian logam Ni yang paling rendah yaitu sebesar 5.32x10 -7 .…”

Section: Risiko Kesehatanunclassified

Logam Berat dan Probabilistik Penilaian Risiko Kesehatan Melalui Konsumsi Beras dari Lahan Sawah di Hulu Sungai Citarum

Handayani¹,

Sukarjo²,

Dewi³

et al. 2022

Jurnal Kesehatan Lingkungan Indonesia

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Latar belakang: Beras merupakan salah satu makanan pokok masyarakat Indonesia sehingga perlu adanya jaminan keamanan pada beras khususnya bebas dari cemaran logam berat. Penelitian ini bertujuan untuk mengetahui kandungan konsentrasi logam berat pada beras yang ditanam pada lahan pertanian di Kabupaten Bandung dan menganalisis risiko kesehatan masyarakat yang mengkonsumsi beras tersebut.Metode: penentuan lokasi pengambilan contoh dilakukan dengan metode purposive sampling pada lahan pertanian yang siap panen di beberapa kecamatan di Kabupaten Bandung dengan jumlah contoh beras sebanyak 26 sampel. Analisis logam berat yang dilakukan adalah analisis logam berat Pb, Cd, Cr, Ni, Co, Cu dan Zn dengan ekstrak HNO3:HClO4 dan diukur menggunakan Atomic Absorbption Spectrophotometer (AAS). Analisis probabilistik penilaian risiko kesehatan masyarakat dilakukan dengan menganalisis nilai estimated daily intake (EDI), estimated weekly intake (EWI), risiko non-karsinogenik dan risiko karsinogenik. Hasil: semua contoh beras mengandung logam berat Cr, Co, Cu dan Zn dengan nilai konsentrasi berturut-turut berkisar antara 0.64-2.28 mgkg-1, 1.18-2.66 mgkg-1, 0.64-3.47 mgkg-1 dan 5.44-8.69 mgkg-1. Konsentrasi logam Cu pada contoh beras yang diambil pada lahan pertanian kawasan industri berbeda nyata dengan contoh beras di luar kawasan industri dengan nilai p sebesar 0.014. Risiko non-karsinogenik yang ditimbulkan jika mengkonsumsi beras dari lahan pertanian Kabupaten Bandung tidak mungkin untuk terjadi karena nilai hazard index (HI) menunjukkan angka <1, nilai HI secara berurutan yaitu anak-anak (0.0880)>remaja (0.0370)>dewasa (0.0259)>manula (0.0281) dan risiko karsinogenik juga menunjukkan nilai yang dapat ditoleransi karena di bawah 10-4 untuk semua katogeri umur (anak-anak, remaja, dewasa, manula) dengan nilai cancer risk (CR) berturut-turut sebesar 6.15x10-7, 6.72x10-7, 2.53x10-6 dan 2.74x10-6.Simpulan: beras yang dihasilkan dari lahan pertanian di Kabupaten Bandung aman untuk dikonsumsi oleh masyarakat karena risiko kesehatan yang ditimbulkan masih dapat ditoleransi ABSTRACTTitle: Heavy Metals and Probabilistic Risk Assessment Via Rice Consumption From Rice Fields in Upstream of The Citarum River Background: Rice is one of the staple foods of the Indonesian people, so it is necessary to guarantee the safety of rice, especially free from heavy metal contamination. This study aims to determine the concentration of heavy metals in rice grown on agricultural land in Bandung Regency and analyze the health risks of the people who consume the rice. Method: the determination of location of sampling was carried out by purposive sampling method on agricultural land that was ready for harvest in several sub-districts in Bandung Regency with a total of 26 samples of rice. Heavy metal analysis carried out was heavy metal analysis of Pb, Cd, Cr, Ni, Co, Cu and Zn with HNO3:HClO4 extract and measured using Atomic Absorption Spectrophotometer (AAS). Probabilistic analysis of public health risk assessment was carried out by analyzing the estimated daily intake (EDI), estimated weekly intake (EWI), non-carcinogenic risk and carcinogenic risk.Results: all rice samples contained Cr, Co, Cu and Zn metals with concentration values ranging from 0.64-2.28 mgkg-1, 1.18-2.66 mgkg-1, 0.64-3.47 mgkg-1 and 5.44-8.69 mgkg-1, respectively. The concentration of Cu metal in rice samples taken on agricultural land in industrial areas was significantly different from rice samples outside industrial areas with a p value of 0.01. The non-carcinogenic risk caused by consuming rice from agricultural land in Bandung Regency is unlikely to occur because the hazard index (HI) value shows the number <1, the HI values are children (0.0880)>adolescents (0.0370)>adults (0.0259 )> the elderly (0.0281) and the carcinogenic risk also shows a value that can be tolerated because it was below 10-4 for all age categories (children, adolescents, adults and the elderly) with a cancer risk (CR) value of 6.15x10-7, 6.72x10-7, 2.53x10-6 and 2.74x10-6.Conclution: Rice produced from agricultural land in Bandung Regency is safe for consumption by the community because the health risks caused are still tolerable.

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Association of As, Pb, Cr, and Zn urinary heavy metals levels with predictive indicators of cardiovascular disease and obesity in children and adolescents

Cited by 54 publications

References 56 publications

Blood Chromium Levels and Their Association with Cardiovascular Diseases, Diabetes, and Depression: National Health and Nutrition Examination Survey (NHANES) 2015–2016

Blood Chromium Levels and Their Association with Cardiovascular Diseases, Diabetes, and Depression: National Health and Nutrition Examination Survey (NHANES) 2015–2016

Nitric Oxide Mobilizes Intracellular Zn2+ via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation

Logam Berat dan Probabilistik Penilaian Risiko Kesehatan Melalui Konsumsi Beras dari Lahan Sawah di Hulu Sungai Citarum

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