Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study

Biggelaar, Louise J. C. J. den; Sep, Simone J. S.; Mari, Andrea; Ferrannini, Ele; Dongen, M.C.J.M. van; Wijckmans, Nicole E. G.; Schram, Miranda T.; Kallen, Carla; Schaper, Nicolaas C.; Henry, Ronald M.A.; Greevenbroek, Marleen M.J. van; Stehouwer, Coen D. A.; Eussen, Simone J. P. M.

doi:10.1007/s00394-019-02026-0

Cited by 16 publications

(10 citation statements)

References 45 publications

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“…Epidemic studies have shown that heavy consumption of high fructose corn syrup is associated with the development of cardiovascular and metabolic diseases. However, despite research proving its negative impact on human health, the use of high-fructose corn syrup is not presently not restricted 145,[149][150][151]156 . Sucralose (Splenda) is a non-caloric high intensity sweetener that has been approved globally since 1998 by the FDA for use in foods and beverages [157][158][159] .…”

Section: Discussionmentioning

confidence: 99%

Energy Drinks; Impact of Use in Patients with Diabetes, Obesity, and/or other Cardiometabolic Spectrum Conditions.

Moran

Labrada²,

Grissett³

et al. 2022

MARJ

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Energy drinks (EDs) are a brand of non-alcoholic beverages that are typically distinguished from regular sweetened caloric beverages (SCBs) by their augmented carbohydrate and purine alkaloids/methylxanthines (usually either caffeine; 1,3,7 trimethylxanthine and/or theobromine; 3,7 dimethylxanthine) content touted as being able to boost energy levels. At initial inception they were dominantly consumed by young adults (with an initial strong male preponderance) but in the last few decades as their variety, main-stream acceptance and widespread marketing has increased their appeal and consumption has become widespread and virtually universal to the general population including virtually all age, gender and ethno-racial demographics. With increased widespread consumption concerns regarding their safety and potential impact on long term health have started being raised. This is particularly pertinent as their regulatory oversight and monitoring is often presently minimal. Diabetes and Obesity represent two dominant halves of the global diabesity epidemic that afflicts over 650 million adults worldwide with over 40% of the adult population in the United States affected. The well documented cardiometabolic spectrum (CMS) of diseases that are associated comorbidities of diabesity are well documented and it is inevitable that the increasing consumption of EDs would involve these group of persons in adult, geriatric, adolescent and even pediatric populations. This review summarizes and synthesizes the limited published data on the described and potential health impact of EDs use particularly in persons with and/or at risk for diabetes, obesity and other CMS diseases to make the case for need of more careful study, monitoring and scrutiny of the use of these beverages in these group of persons. After providing an overview of the history, epidemiology and major components of EDs we detail the major potential and reported systemic complications of their long-term intake especially in at risk populations discussing the modulating effects of genetics, present comorbidities and alcohol co-intake. The prominent roles of caffeine and carbohydrates in the potential poly-systemic effects of EDs and their reported toxidromes is also highlighted while acknowledging the limitations in the present body of published data in this area.

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Section: Discussionmentioning

confidence: 99%

Energy Drinks; Impact of Use in Patients with Diabetes, Obesity, and/or other Cardiometabolic Spectrum Conditions.

Moran

Labrada²,

Grissett³

et al. 2022

MARJ

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“…The other three indices were mathematical model-based parameters: glucose sensitivity index, potentiation factor and the rate sensitivity index. 25 26 These model-based parameters describe insulin secretion as the summed beta cell response to absolute glucose levels. 26 The disposition index was used as a measure of insulin secretion adjusted for the level of insulin sensitivity.…”

Section: Methodsmentioning

confidence: 99%

Spousal concordance in pathophysiological markers and risk factors for type 2 diabetes: a cross-sectional analysis of The Maastricht Study

Silverman-Retana

Brinkhues

Hulmán

et al. 2021

BMJ Open Diab Res Care

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IntroductionWe compared the degree of spousal concordance in a set of detailed pathophysiological markers and risk factors for type 2 diabetes to understand where in the causal cascade spousal similarities are most relevant.Research design and methodsThis is a cross-sectional analysis of couples who participated in The Maastricht Study (n=172). We used quantile regression models to assess spousal concordance in risk factors for type 2 diabetes, including four adiposity measures, two dimensions of physical activity, sedentary time and two diet indicators. We additionally assessed beta cell function and insulin sensitivity and glucose metabolism status with fasting and 2-hour plasma glucose and hemoglobin A1c.ResultsThe strongest spousal concordance (beta estimates) was observed for the Dutch Healthy Diet Index (DHDI) in men. A one-unit increase in wives’ DHDI was associated with a 0.53 (95% CI 0.22 to 0.67) unit difference in men’s DHDI. In women, the strongest concordance was for the time spent in high-intensity physical activity (HPA); thus, a one-unit increase in husbands’ time spent in HPA was associated with a 0.36 (95% CI 0.17 to 0.64) unit difference in women’s time spent in HPA. The weakest spousal concordance was observed in beta cell function indices.ConclusionsSpousal concordance was strongest in behavioral risk factors. Concordance weakened when moving downstream in the causal cascade leading to type 2 diabetes. Public health prevention strategies to mitigate diabetes risk may benefit from targeting spousal similarities in health-related behaviors and diabetes risk factors to design innovative and potentially more effective couple-based interventions.

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“…Sugary drinks are associated to weight gain and increased risk of obesity (Alcalá and Sharif, 2017; Barac et al, 2015; Barbosa et al, 2021; Barnett, 2018; Barro et al, 2020; Bleich and Wolfson, 2015; British Soft Drinks Association Annual Report, 2016; Bruce et al, 2018; Carran et al, 2016; Chan et al, 2020; Cheikh Ismail et al, 2020; Das, 2016; den Biggelaar et al, 2020; Donazar-Ezcurra et al, 2018; Evers et al, 2018; Feig et al, 2008; Fenwick et al, 2018; Ferreira-Pêgo et al, 2016; Ganss, 2006; Gardener et al, 2018; Goodman et al, 2016; Gravelle et al, 2015; Guo et al, 2014; Hallfrisch, 1990; Harrell et al, 2015; Hrolfsdottir et al, 2019; Hu et al, 2018; Husárová et al, 2017; Imamura et al, 2016; Jameel et al, 2016; Johnson et al, 2010; Ju et al, 2019; Kadel et al, 2020; Kashino et al, 2021; Koekkoek et al, 2017; Kwak et al, 2019; Lin et al, 2016; Lin et al, 2021; Malik and Hu, 2015; Malik and Hu, 2022; Pauli and Repke, 2017; Sousa et al, 2020). They can promote weight gain through adverse effects on metabolism, due to their ability to induce rapid spikes in blood glucose and insulin levels (Solomi et al, 2019).…”

Section: Literature Reviewmentioning

confidence: 99%

The challenge of dietary management in soft drink consumption and its oral and systemic repercussions

et al. 2022

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Background:Soft drinks are drinks high in sugar and acidity, but low in nutritional benefits. Despite its great popularity, its consumption is alerted due to the numerous systemic harm caused. Aim:This work aims to provide information and critically review the literature on the risk of soft drink consumption in an integrative view with nutritional, dental, and medical aspects. Methods:A search was carried out based on the identification of the theme, determination of inclusion and exclusion criteria, selection of databases for research and, finally, the reading, interpretation, and discussion of the selected sources. A search was conducted using the keywords: “soft drinks” AND “obesity” OR “dental erosion” OR “diabetes” OR “hypertension” OR “mental health” OR “multimorbidities” in databases PubMed, SciELO, and LILACS between 2017 and 2022. Results:Seventy-six studies were included in the article after the qualitative synthesis. Conclusion:We conclude that the high consumption of soft drinks is associated with oral and general diseases. Therefore, a multi-professional approach to guide patients to moderate the consumption of these beverages is extremely important.

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Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study

Cited by 16 publications

References 45 publications

Energy Drinks; Impact of Use in Patients with Diabetes, Obesity, and/or other Cardiometabolic Spectrum Conditions.

Energy Drinks; Impact of Use in Patients with Diabetes, Obesity, and/or other Cardiometabolic Spectrum Conditions.

Spousal concordance in pathophysiological markers and risk factors for type 2 diabetes: a cross-sectional analysis of The Maastricht Study

The challenge of dietary management in soft drink consumption and its oral and systemic repercussions

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