Association of Apolipoproteins E4 and C1 With Onset Age and Memory: A Study of Sporadic Alzheimer Disease in Taiwan

Chuang, Wen-Li; Hsieh, Yu-Chen; Wang, Chunyi; Kuo, Hung‐Chou; Huang, Chin‐Chang

doi:10.1177/0891988709351804

Cited by 15 publications

(17 citation statements)

References 35 publications

(46 reference statements)

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“…Several authors have attempted to answer this question by conducting analyses of haplotypes of this cluster. Although no consensus has been reached concerning this issue, it appears that a greater number of studies support the hypothesis that the -317*ins allele of the APOC1 gene is a second susceptibility allele, rather than the possibility that this allele is simply inherited together with the E*4 allele of the APOE gene [4,23,24]. Our data also agree with those authors, since they demonstrate that the -317*ins allele of the APOC1 gene is more common among patients than controls even in the presence of the E*3 allele of the APOE gene, which does not cause increased susceptibility to Alzheimer's (Table 2).…”

Section: Discussionmentioning

confidence: 92%

Genetic Influences on Alzheimer’s Disease: Evidence of Interactions Between the Genes APOE, APOC1 and ACE in a Sample Population from the South of Brazil

et al. 2011

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Alzheimer's disease is a complex neurodegenerative disorder. Several genes have been suggested as Alzheimer's susceptibility factors, the apolipoprotein E (APOE) gene being an established susceptibility gene and the genes coding angiotensin-converting enzyme (ACE) and apolipoprotein C1 (APOC1) being considered possible candidate genes for the disease. The objective of this study was to investigate the association of ACE and APOC1 gene polymorphisms with susceptibility to Alzheimer's disease and dementia in general, both alone and combined with the APOE gene. Forty-seven patients with dementia in general (35 of them with Alzheimer's disease) and 85 controls were investigated. The haplotypes E*3/-317*ins and E*4/-317*ins of APOE/APOC1 genes were significantly more frequent in the groups with Alzheimer's disease and dementia in general (P < 0.001). The frequency of the ACE*ins allele was also greater in the groups with Alzheimer's disease and dementia in general (P = 0.022; P = 0.045), but genotype frequencies were only different in groups without the E*4/-317*ins haplotype (P = 0.012 for Alzheimer's disease; P = 0.04 for dementia). Our data point to important genetic interactions involved in these diseases.

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Section: Discussionmentioning

confidence: 92%

Genetic Influences on Alzheimer’s Disease: Evidence of Interactions Between the Genes APOE, APOC1 and ACE in a Sample Population from the South of Brazil

et al. 2011

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“…Of the 44 full-text articles, 30 were further excluded for various reasons ( Figure 1 ). Fourteen case-control articles met the preliminary inclusion criteria [9], [10], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23]. The study by Chartier-Harlin et al .…”

Section: Resultsmentioning

confidence: 99%

“…[23]. The most common AD diagnostic criteria was from NINCDS-ADRDA [10], [12], [14], [16], [17], [18], [19], [20], [21], [22], [23]. Four studies [9], [15], [17], [21] used the Diagnostic and Statistical Manual of Mental Disorders, third/fourth edition (DSM-III-R or DSM-IV) criteria, and one study [22] used the International Classification of diseases, Tenth Revision (ICD-10).…”

Section: Resultsmentioning

confidence: 99%

“…But so far, it hasn’t actually ever been proved if APOC1 rs11568822 polymorphism is associated with AD risk, and there is a lack of the meta-analysis evidences from different ethnic groups from multiple countries in the world. Although the association between the APOC1 rs11568822 polymorphism and AD risk has been hotly debated in many studies [9], [10], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], the results of these studies are conflicting and ambiguous, partially due to the relatively small sample size of individual studies and a wide range of ethnic groups. Therefore, we conducted a two-stage study to obtain more comprehensive understanding of the relationship between APOC1 rs11568822 polymorphism and AD risk in a wide range of populations.…”

Section: Introductionmentioning

confidence: 99%

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Association between APOC1 Polymorphism and Alzheimer’s Disease: A Case-Control Study and Meta-Analysis

Zhou

Zhao

et al. 2014

PLoS ONE

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BackgroundPrevious association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer’s disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations.MethodsTo confirm the risk association between APOC1 and AD, we designed a case-control study and also performed a meta-analysis of previously published studies.ResultsSeventy-nine patients with AD and one hundred fifty-six unrelated controls were included in case-control study. No association was found between the variation of APOC1 and AD in stage 1 of our study. However, our meta-analysis pooled a total of 2092 AD patients and 2685 controls. The APOC1 rs11568822 polymorphism was associated with increased AD risk in Caucasians, Asians and Caribbean Hispanics, but not in African Americans. APOE ε4 carriers harboring the APOC1 insertion allele, were more prevalent in AD patients than controls (χ2 = 119.46, OR = 2.79, 95% CI = 2.31–3.36, P<0.01).ConclusionsThe APOC1 insertion allele, in combination with APOE ε4, likely serves as a potential risk factor for developing AD.

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“…In studies from China, APOE ε4 has been correlated with AD risk [7,35–37], as well as cognitive decline and memory performance in mild cognitive impairment (MCI) [38–40]. Neuroimaging studies found smaller hippocampal volumes in symptomatic ε4 carriers [35,41], but not among cognitively normal ε4-carrying controls [35].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein ε4 Is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults

et al. 2015

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Studying ethnically diverse groups is important for furthering our understanding of biological mechanisms of disease that may vary across human populations. The ε4 allele of apolipoprotein E (APOE ε4) is a well-established risk factor for Alzheimer’s disease (AD), and may confer anatomic and functional effects years before clinical signs of cognitive decline are observed. The allele frequency of APOE ε4 varies both across and within populations, and the size of the effect it confers for dementia risk may be affected by other factors. Our objective was to investigate the role APOE ε4 plays in moderating brain volume in cognitively normal Chinese older adults, compared to older white Americans. We hypothesized that carrying APOE ε4 would be associated with reduced brain volume and that the magnitude of this effect would be different between ethnic groups. We performed whole brain analysis of structural MRIs from Chinese living in America (n = 41) and Shanghai (n = 30) and compared them to white Americans (n = 71). We found a significant interaction effect of carrying APOE ε4 and being Chinese. The APOE ε4xChinese interaction was associated with lower volume in bilateral cuneus and left middle frontal gyrus (Puncorrected<0.001), with suggestive findings in right entorhinal cortex and left hippocampus (Puncorrected<0.01), all regions that are associated with neurodegeneration in AD. After correction for multiple testing, the left cuneus remained significantly associated with the interaction effect (PFWE = 0.05). Our study suggests there is a differential effect of APOE ε4 on brain volume in Chinese versus white cognitively normal elderly adults. This represents a novel finding that, if verified in larger studies, has implications for how biological, environmental and/or lifestyle factors may modify APOE ε4 effects on the brain in diverse populations.

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Association of Apolipoproteins E4 and C1 With Onset Age and Memory: A Study of Sporadic Alzheimer Disease in Taiwan

Cited by 15 publications

References 35 publications

Genetic Influences on Alzheimer’s Disease: Evidence of Interactions Between the Genes APOE, APOC1 and ACE in a Sample Population from the South of Brazil

Genetic Influences on Alzheimer’s Disease: Evidence of Interactions Between the Genes APOE, APOC1 and ACE in a Sample Population from the South of Brazil

Association between APOC1 Polymorphism and Alzheimer’s Disease: A Case-Control Study and Meta-Analysis

Apolipoprotein ε4 Is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults

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