Association of APOEpolymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study

Chu, Audrey Y.; Parekh, Rulan S.; Astor, Brad C.; Coresh, Josef; Berthier-Schaad, Yvette; Smith, Michael W.; Shuldiner, Alan R.; Kao, W. H. Linda

doi:10.1186/1471-2350-10-108

Cited by 37 publications

(27 citation statements)

References 47 publications

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“…A weak association between the e4 allele and a low glomerular filtration rate was recently demonstrated. 22 However, the role of apoE in human renal diseases remains controversial. Roussos et al showed decreased frequency of e4 allele in patients with glomerulonephritis and increased frequency of this allele in patients with autosomal dominant polycystic kidney disease.…”

Section: Discussionmentioning

confidence: 99%

Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis

et al. 2014

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“…Previous studies of the relationship between apo E polymorphism and DN, which were conducted in White, Black and Hispanic Americans, have produced conflicting results [12,13,14]. These studies had small sample sizes, were cross-sectional in design, and had different definitions of outcome.…”

Section: Introductionmentioning

confidence: 98%

Apolipoprotein E Polymorphism and the Progression of Diabetic Nephropathy in Type 2 Diabetes

Tien

Chou

et al. 2011

Am J Nephrol

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Background/Aims: Three different apo E alleles (E2, E3 and E4) produce apo E isoproteins, which regulate the metabolism of lipoproteins. This study investigated the apo E polymorphisms as a prognostic factor for the development of diabetic nephropathy (DN). Methods: A total of 525 type 2 diabetic patients were enrolled to participate in this prospective observational study. Apo E gene polymorphisms were analyzed by polymerase chain reaction. The progression of DN was defined as a shift to a higher stage of DN or a doubling of the baseline serum creatinine level by the end of the study. Results: The mean follow-up period was 42.4 months. The patients whose DN progressed had significantly higher urine albumin/creatinine ratios and fewer used diuretics than those in whom DN did not progress. In the Cox regression analysis, the apo E4 carriers were found to be at greater risk of progression of DN than non-apo E4 carriers (p = 0.007, hazard ratio 2.252). After adjusting for confounding factors, apo E4 carriers remained at increased risk of progression to more severe DN (p = 0.002, hazard ratio 2.820). Conclusion: Our study suggests the apo E4 carrier might serve as a predictor of DN progression in Taiwan.

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“…The 2 APOE variants were genotyped by TaqMan assay (Applied Biosystems; Foster City, CA). 26 All remaining variants were genotyped either by GoldenGate (Illumina; San Diego, CA) or by iPLEX or iPLEX Gold (Sequenom; San Diego, CA). 27 All SNPs were in Hardy-Weinberg proportions according to the National Center for Health Statistics criterion (http://www.cdc.gov/nchs/nhanes/genetics/genetic.htm).…”

Section: Snp Selection and Genotyping Methodsmentioning

confidence: 99%

Racial/Ethnic Variation in the Association of Lipid-Related Genetic Variants With Blood Lipids in the US Adult Population

Chang

Ned

Hong

et al. 2011

Circ Cardiovasc Genet

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Background-Genome-wide association studies (GWAS) have identified a number of single-nucleotide polymorphisms (SNPs) associated with serum lipid level in populations of European descent. The individual and the cumulative effect of these SNPs on blood lipids are largely unclear for the US population. Methods and Results-Using data from the second phase (1991)(1992)(1993)(1994) of the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative survey of the US population, we examined associations of 57 GWAS-identified or well-established lipid-related genetic loci with plasma concentrations of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, total cholesterol, triglycerides, total cholesterol/ HDL-C ratio, and non-HDL-C. We used multivariable linear regression to examine single SNP associations and the cumulative effect of multiple SNPs (using a genetic risk score [GRS]) on blood lipid levels. Analyses were conducted in adults from each of the 3 major racial/ethnic groups in the United States: non-Hispanic whites (nϭ2296), non-Hispanic blacks (nϭ1699), and Mexican Americans (nϭ1713). Allele frequencies for all SNPs varied significantly by race/ethnicity, except rs3764261 in CETP. Individual SNPs had very small effects on lipid levels, effects that were generally consistent in direction across racial/ethnic groups. More GWAS-validated SNPs were replicated in non-Hispanic whites (Ͻ67%) than in non-Hispanic blacks (Ͻ44%) or Mexican Americans (Ͻ44%). GRSs were strongly associated with increased lipid levels in each racial/ethnic group. The combination of all SNPs into a weighted GRS explained no more than 11% of the total variance in blood lipid levels. Conclusions-Our findings show that the combined association of SNPs, based on a GRS, was strongly associated with increased blood lipid measures in all major race/ethnic groups in the United States, which may help in identifying subgroups with a high risk for an unfavorable lipid profile. (Circ Cardiovasc Genet. 2011;4:523-533.)Key Words: nutrition surveys Ⅲ lipids Ⅲ continental population groups Ⅲ ethnology Ⅲ cholesterol Ⅲ genetics Ⅲ risk G enome-wide association studies (GWAS) have successfully identified numerous genetic loci associated with blood lipid levels, which are known risk factors for cardiovascular disease. [1][2][3][4][5][6][7][8] These studies have confirmed some risk loci identified in previous candidate gene and linkage analyses, and they have uncovered a panel of new candidate loci for lipid traits such as total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Meta-analyses of GWAS have proven fruitful as well. A recent meta-analysis of blood lipid studies reported significant associations of 95 loci with lipid traits in Ͼ100 000 individuals of European ancestry, most of which had concordant effects in nonEuropean populations. 3 Nevertheless, studies have reported racial/ethnic variation in blood li...

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Association of APOEpolymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study

Cited by 37 publications

References 47 publications

Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis

Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis

Apolipoprotein E Polymorphism and the Progression of Diabetic Nephropathy in Type 2 Diabetes

Racial/Ethnic Variation in the Association of Lipid-Related Genetic Variants With Blood Lipids in the US Adult Population

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